Bernardino Alcázar Navarrete
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View article: Cardiopulmonary risk in the COPD patient: the EPOCONSUL audit
Cardiopulmonary risk in the COPD patient: the EPOCONSUL audit Open
Having cardiovascular disease associated with COPD is important, as it increases the risk of adverse cardiopulmonary events. to evaluate the characteristics of COPD patients with cardiovascular disease (CVD) and the therapeutic measures ad…
View article: Real-World Outcomes in Patients with COPD Initiating Budesonide/Glycopyrronium/Formoterol Fumarate Dehydrate in Spain: ORESTES Study
Real-World Outcomes in Patients with COPD Initiating Budesonide/Glycopyrronium/Formoterol Fumarate Dehydrate in Spain: ORESTES Study Open
NCT06321731.
View article: Assessment of peak inspiratory flow in patients with chronic obstructive pulmonary disease: a multicentre, observational, prospective, real-life study
Assessment of peak inspiratory flow in patients with chronic obstructive pulmonary disease: a multicentre, observational, prospective, real-life study Open
Introduction Patients with chronic obstructive pulmonary disease (COPD) use dry powder inhalers (DPIs) for disease management. DPI effectiveness relies on the patient’s peak inspiratory flow (PIF), which may not always be optimal. We condu…
View article: Early Acquisition of E-fast Ultrasound Skills in Medical Students: An Observational Study Comparing Portable and Conventional Devices
Early Acquisition of E-fast Ultrasound Skills in Medical Students: An Observational Study Comparing Portable and Conventional Devices Open
Background The E-FAST (Extended Focused Assessment with Sonography in Trauma) protocol is an essential diagnostic tool in emergency medicine. Its structured format and diagnostic relevance make it ideal for early clinical training. The aim…
View article: Biological Therapy in COPD Management: Current Evidence, Challenges and Opportunities
Biological Therapy in COPD Management: Current Evidence, Challenges and Opportunities Open
The goals of COPD treatment are to improve symptoms and decrease future risks such as exacerbations, lung function decline and mortality. Despite receiving maximal inhaled treatment, many COPD patients continue to exacerbate. This highligh…
View article: Characteristics and actions in high-risk COPD in unstable patients: The EPOCONSUL audit
Characteristics and actions in high-risk COPD in unstable patients: The EPOCONSUL audit Open
Objective: To assess the clinical characteristics of high-risk COPD patients considered not stable for having had moderate or severe exacerbations of COPD in the three months prior to the audited review visit based on information extracted…
View article: Mepolizumab for Eosinophilic COPD: What Matinee Adds to COPD Management?
Mepolizumab for Eosinophilic COPD: What Matinee Adds to COPD Management? Open
View article: Delphi Consensus on the Management of COPD Exacerbation Syndrome in Inpatient and Outpatient Settings
Delphi Consensus on the Management of COPD Exacerbation Syndrome in Inpatient and Outpatient Settings Open
View article: Management of Patients with Chronic Obstructive Pulmonary Disease Attended at Primary Care in Granada: A Clinical Audit
Management of Patients with Chronic Obstructive Pulmonary Disease Attended at Primary Care in Granada: A Clinical Audit Open
Keywords: COPD, primary care, audit, disease management.
View article: How to move towards more sustainable asthma care in Europe: an expert opinion paper
How to move towards more sustainable asthma care in Europe: an expert opinion paper Open
The healthcare sector is one of the primary emitters of greenhouse gases in the public sector; this viewpoint's distillation of expert opinions emphasises what more sustainable asthma care could look like and presents possible solutions…
View article: The perfect storm: when COPD meets bronchiectasis
The perfect storm: when COPD meets bronchiectasis Open
COPD can coexist with bronchiectasis (BE). These patients have different clinical profiles compared to those with BE with fixed airflow limitation. https://bit.ly/3Z9qNOb.
View article: Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study
Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study Open
Aims Cardiovascular disease is a common comorbidity in chronic obstructive pulmonary disease. Yet, cardiovascular disease and risk are underdiagnosed in chronic obstructive pulmonary disease and are often undertreated, increasing the risk …
View article: Delphi Consensus on the Management of Patients With Advanced COPD: COPD-Avanz Working Group
Delphi Consensus on the Management of Patients With Advanced COPD: COPD-Avanz Working Group Open
In this document, a broad panel of experts reached a high degree of consensus on the definition of advanced COPD as well as on its approach. The information provided by this consensus is intended to assist the clinician in the identificati…
View article: Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Proposed in the Spanish COPD Guidelines (GesEPOC): Results of the EPOCONSUL Audit
Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Proposed in the Spanish COPD Guidelines (GesEPOC): Results of the EPOCONSUL Audit Open
Introduction/Objective: the concept of clinical control of COPD is a measure proposed in the Spanish COPD Guidelines (GesEPOC), which aims to help clinicians assess the clinical status in order to adapt the treatment plan at follow-up. How…
View article: Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit Open
Objective This study aimed to evaluate clinical control in chronic obstructive pulmonary disease (COPD), the consequences in terms of treatment decisions, and their potentially associated factors during follow-up of patients in real-life c…
View article: Development  and Validation of PRECISE-X, a Risk Prediction Model for the First Severe Exacerbation in Patients with Chronic Obstructive Pulmonary Disease
Development and Validation of PRECISE-X, a Risk Prediction Model for the First Severe Exacerbation in Patients with Chronic Obstructive Pulmonary Disease Open
View article: Short Term Exacerbation Risk and Exhaled Nitric Oxide in Copd
Short Term Exacerbation Risk and Exhaled Nitric Oxide in Copd Open
View article: Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD
Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Open
Introduction: The control of Chronic Obstructive Pulmonary Disease (COPD) introduces a novel evaluative element in the management of COPD. There is a need for promoting its evaluation through a quantitative assessment to facilitate the int…
View article: Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial
Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial Open
View article: Multidimensional Analysis of Quality of Life in Patients with Chronic Non-Cancer Pain and Short- and Long-Term Intrathecal Analgesic Therapy
Multidimensional Analysis of Quality of Life in Patients with Chronic Non-Cancer Pain and Short- and Long-Term Intrathecal Analgesic Therapy Open
Background: Intrathecal drug delivery (IDD) is part of the fourth analgesic step. Evidence on the quality of life of patients with refractory chronic non-cancer pain (CNCP) using these devices and their long-term outcomes is scarce. This s…
View article: Five years of advances in electrochemical analysis of protein biomarkers in lung cancer: a systematic review
Five years of advances in electrochemical analysis of protein biomarkers in lung cancer: a systematic review Open
Lung cancer is the leading cause of cancer death in both men and women. It represents a public health problem that must be addressed through the early detection of specific biomarkers and effective treatment. To address this critical issue…
View article: Triple Therapy and Clinical Control in B+ COPD Patients: A Pragmatic, Prospective, Randomized Trial
Triple Therapy and Clinical Control in B+ COPD Patients: A Pragmatic, Prospective, Randomized Trial Open
The ANTES B+ study is the first to: (1) explore the efficacy and safety of triple therapy in a population of B+ COPD patients and (2) use a composite index (CC) as the primary result of a COPD trial.
View article: Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit Open
Objective: The aim of the study was to evaluate the clinical control in chronic obstructive pulmonary disease (COPD), the consequences in terms of treatment decisions and their potentially associated factors during follow-up of patients in…
View article: Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score Open
COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.
View article: Antifibrotic treatment adherence, efficacy and outcomes for patients with idiopathic pulmonary fibrosis in Spain: a real-world evidence study
Antifibrotic treatment adherence, efficacy and outcomes for patients with idiopathic pulmonary fibrosis in Spain: a real-world evidence study Open
Background Idiopathic pulmonary fibrosis (IPF) is a rare disorder associated with increased mortality and morbidity. There are currently two drugs approved for IPF but their safety and efficacy profile in real-world settings in Spain is no…
View article: Corrigendum to “Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats” [Biomed. Pharmacother. 172 (2024) 116314]
Corrigendum to “Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats” [Biomed. Pharmacother. 172 (2024) 116314] Open
The authors regret the human error made in funding. Following the instructions of the Spanish Ministry to have no problem with the payment, the funding given had data from funders repeated, and following their instructions, the funding sho…
View article: Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats
Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats Open
View article: Detection of Alpha-1 Antitrypsin Levels in Chronic Obstructive Pulmonary Disease in Respiratory Clinics in Spain: Results of the EPOCONSUL 2021 Audit
Detection of Alpha-1 Antitrypsin Levels in Chronic Obstructive Pulmonary Disease in Respiratory Clinics in Spain: Results of the EPOCONSUL 2021 Audit Open
Background: Alpha-1 antitrypsin deficiency (AATD) is an underdiagnosed condition despite being one of the most common inherited disorders in adults that is associated with an increased risk of developing chronic obstructive pulmonary disea…
View article: Multidisciplinary Management of Patients With Chronic Obstructive Pulmonary Disease and Cardiovascular Disease
Multidisciplinary Management of Patients With Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Open
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist, increasing the prevalence of both entities and impacting on symptoms and prognosis. CVD should be suspected in patients with COPD who have hi…
View article: Inhaler Adherence in COPD: A Crucial Step Towards the Correct
Inhaler Adherence in COPD: A Crucial Step Towards the Correct Open
COPD is a typical example of chronic disease. As such, treatment adherence tends to be as low as between 30% and 50%, with specific issues in COPD due to the use of inhaled therapies. Decreased adherence in COPD is associated with worse ou…