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Occult tethered cord syndrome: insights into clinical and MRI features, prognostic factors, and treatment outcomes in 30 dogs with confirmed or presumptive diagnosis Open
Occult tethered cord syndrome (OTCS) is poorly documented in dogs. This retrospective multicenter study evaluated the clinical presentation, MRI findings, treatment outcomes, and prognostic factors in 30 dogs diagnosed with OTCS managed su…
Acute Symmetric Arterial Thrombosis of the Four Extremities Associated with Pregnancy: Case Report Open
During the normal process of pregnancy, there is a procoagulant state derived from the alteration of all the components of the Virchow Triad. Multiple biochemical and structural changes lead to an increased risk of thromboembolic events. A…
Takotsubo cardiomyopathy secondary to electroconvulsive therapy in a young adult with Down syndrome regression disorder Open
We report the case of an 18‐year‐old woman with Down syndrome (DS) who developed Takotsubo cardiomyopathy (TSC) immediately after the administration of electroconvulsive therapy (ECT), a treatment prescribed for Down syndrome regression di…
Immunotherapy responsiveness and risk of relapse in Down syndrome regression disorder Open
Down syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric regression without an identifiable cause. This study evaluated the clinical effectiveness of IVIg and evaluated clinical characteristics …
Assessment and Diagnosis of Down Syndrome Regression Disorder: International Expert Consensus Open
Objective To develop standardization for nomenclature, diagnostic work up and diagnostic criteria for cases of neurocognitive regression in Down syndrome. Background There are no consensus criteria for the evaluation or diagnosis of neuroc…
Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome Open
Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospectiv…
Insulin Doses Requirements in Patients with Type 1 Diabetes Using Glargine U300 or Degludec in Routine Clinical Practice Open
There are not many real-world studies evaluating daily insulin doses requirements (DIDR) in patients with type 1 diabetes (T1D) using second-generation basal insulin analogs, and such comparison is necessary. The aim of this study was to c…
Emergency Room Thoracotomy (ERT): A retrospective audit of results. Open
Background: An Emergency Room Thoracotomy (ERT) is a resource-intensive, high-risk procedure in which rapid decision-making is essential. In a resource-constrained system, identification of the group of patients that could achieve the best…
An international survey on the impact of COVID-19 in individuals with Down syndrome Open
Background Health conditions and immune dysfunction associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19 once infected by SARS-CoV-2. Methods The T21RS COVID-19 Initiative launched an international surv…
105 Time intervals from the first symptom to surgery of ovarian malignancies in a tertiary hospital Open
This cross-sectional study aimed to determine the time intervals from the first symptom to surgery of 37 patients with ovarian malignancies who underwent surgery at a tertiary government hospital from June to October 2019. Structured inter…