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View article: Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment
Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment Open
Since 2006, the responsible regulatory bodies have proposed five health-based guidance values (HBGV) for bisphenol A (BPA) that differ by a factor of 250,000. This range of HBGVs covers a considerable part of the range from highly toxic to…
View article: Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Open
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View article: Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity Open
Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
View article: Data from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
Data from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity Open
The hOGG1 gene encodes the DNA glycosylase that removes the mutagenic lesion 7,8-dihyro-8-oxoguanine (8-oxoG) from DNA. A frequently found polymorphism resulting in a serine to cysteine substitution at position 326 of the OGG1 protein has …
View article: Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity Open
Supplementary Figures 1-4, Table 1 from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
View article: Data from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity
Data from Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity Open
The hOGG1 gene encodes the DNA glycosylase that removes the mutagenic lesion 7,8-dihyro-8-oxoguanine (8-oxoG) from DNA. A frequently found polymorphism resulting in a serine to cysteine substitution at position 326 of the OGG1 protein has …
View article: Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage Open
Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclea…
View article: Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal
Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal Open
One of the most abundant DNA lesions induced by oxidative stress is the highly mutagenic 8-oxoguanine (8-oxoG), which is specifically recognized by 8-oxoguanine DNA glycosylase 1 (OGG1) to initiate its repair. How DNA glycosylases find sma…
View article: <i>N</i>-Methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains
<i>N</i>-Methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains Open
Methylation at the N(2) nitrogen atom of β-carbolines: the key to fine-tuning their interaction with DNA and the cellular uptake dynamics.
View article: Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy
Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy Open
In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitiz…
View article: Impaired DNA demethylation of C/EBP sites causes premature aging
Impaired DNA demethylation of C/EBP sites causes premature aging Open
Changes in DNA methylation are among the best-documented epigenetic alterations accompanying organismal aging. However, whether and how altered DNA methylation is causally involved in aging have remained elusive. GADD45α (growth arrest and…
View article: PO-002 Angiotensin II-induced hypertension increases the mutation frequency in the rat kidney
PO-002 Angiotensin II-induced hypertension increases the mutation frequency in the rat kidney Open
Introduction Epidemiological studies revealed an increased risk for kidney cancer in hypertensive patients. In many of these patients, the blood pressure regulating renin angiotensin aldosterone system (RAAS) is activated. A stimulated RA…
View article: DNA Oxidation Photoinduced by Norharmane Rhenium(I) Polypyridyl Complexes: Effect of the Bidentate N,N′‐Ligands on the Damage Profile
DNA Oxidation Photoinduced by Norharmane Rhenium(I) Polypyridyl Complexes: Effect of the Bidentate N,N′‐Ligands on the Damage Profile Open
Re I ‐polypyridyl complexes have interesting and distinctive photochemical and photosensitizing properties. This work describes the capability to induce (or photoinduce) DNA damage of three Re I ‐complexes with a naturally occurring alkalo…
View article: DNA damage photo-induced by chloroharmine isomers: hydrolysis<i>versus</i>oxidation of nucleobases
DNA damage photo-induced by chloroharmine isomers: hydrolysis<i>versus</i>oxidation of nucleobases Open
Photo-excited chloroharmines selectively induce different types of DNA damage, depending on the relative position of the chlorine atom in the β-carboline ring.
View article: Albumin–Folate Conjugates for Drug‐targeting in Photodynamic Therapy
Albumin–Folate Conjugates for Drug‐targeting in Photodynamic Therapy Open
Photodynamic therapy ( PDT ) is based on the cytotoxicity of photosensitizers in the presence of light. Increased selectivity and effectivity of the treatment is expected if a specific uptake of the photosensitizers into the target cells, …
View article: Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine
Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine Open
DNA damage can significantly modulate expression of the affected genes either by direct structural interference with transcription components or as a collateral outcome of cellular repair attempts. Thus, DNA glycosylases of the base excisi…
View article: Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress
Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress Open
XRCC1 is an essential protein required for the maintenance of genomic stability through its implication in DNA repair. The main function of XRCC1 is associated with its role in the single-strand break (SSB) and base excision repair (BER) p…