Bernd Mayer
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View article: Functionalisation of PTCDA to PDI derivatives: impact on optical and fundamental bandgap, solubility, and electronic structure
Functionalisation of PTCDA to PDI derivatives: impact on optical and fundamental bandgap, solubility, and electronic structure Open
The transformation of 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) to perylene diimide (PDI) and further derivatives offers a promising strategy to tailor the solubility and electronic properties of organic semiconductors for optoe…
View article: Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue
Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue Open
BACKGROUND: Perivascular adipose tissue (PVAT) fine-tunes blood vessel contractility and vascular homeostasis. During obesity and atherosclerosis, PVAT becomes dysfunctional and loses its anticontractile potential. Previously, we reported …
View article: Unsaturated fatty acids identified as reversible soluble guanylyl cyclase inhibitors
Unsaturated fatty acids identified as reversible soluble guanylyl cyclase inhibitors Open
As key enzyme in the NO/cGMP pathway, soluble guanylyl cyclase (sGC) has become an important therapeutic target in the treatment of cardiovascular diseases. In addition to activating compounds, inhibitors of sGC are necessary tools in rese…
View article: Ester‐Aroyl‐S,N‐Ketene Acetals with Solid‐State Luminescence: AIEgens from Sequential Three‐Component Desymmetrization
Ester‐Aroyl‐S,N‐Ketene Acetals with Solid‐State Luminescence: AIEgens from Sequential Three‐Component Desymmetrization Open
Di(hetero)aroyl dichlorides are desymmetrized upon sequential reaction with alcohols and 2‐methyl N ‐benzyl thiazolium salts within the course of a one‐pot three‐component reaction yielding ester‐substituted aroyl‐ S , N ‐ketene acetals un…
View article: AICAr inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity
AICAr inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity Open
Doxorubicin is an effective cancer chemotherapeutic, but its use is complicated by cardiotoxic side-effects. 5-amino-4-imidazolecarboxamide ribonucleoside (AICAr) is a widely used pharmacological activator of adenosine monophosphate activa…
View article: A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads
A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads Open
A general chemoproteomic profiling approach for oxidoreductases with conceptually novel probes based on diarylhalonium salts is reported.
View article: An adenosinergic positive feedback loop extends pharmacological cardioprotection duration
An adenosinergic positive feedback loop extends pharmacological cardioprotection duration Open
Background and Purpose Adenosine receptor activation induces delayed, sustained cardioprotection against ischaemia–reperfusion (IR) injury (24–72 h), but the mechanisms underlying extended cardioprotection duration remain unresolved. We hy…
View article: Natural compounds from cured tobacco are reversible inhibitors of soluble guanylyl cyclase
Natural compounds from cured tobacco are reversible inhibitors of soluble guanylyl cyclase Open
As a key enzyme in the NO/cGMP signaling pathway, soluble guanylyl cyclase (sGC) has become an important target in the therapy of cardiovascular diseases. In addition to activating compounds, inhibitors of sGC are important tools in resear…
View article: Cyclohexene‐Embedded Dicyanomethylene Merocyanines – Consecutive Three‐Component Coupling‐Addition Synthesis and Chromophore Characteristics
Cyclohexene‐Embedded Dicyanomethylene Merocyanines – Consecutive Three‐Component Coupling‐Addition Synthesis and Chromophore Characteristics Open
A concise and efficient consecutive three‐component alkynylation‐addition synthesis of cyclohexene‐embedded dicyanomethylene merocyanines furnishes a small library of dyes in moderate to excellent yield. The dyes possess strong absorption …
View article: Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node
Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node Open
Sepsis has emerged as a global health burden associated with multiple organ dysfunction and 20% mortality rate in patients. Numerous clinical studies over the past two decades have correlated the disease severity and mortality in septic pa…
View article: Sulfate in streams and groundwater in a cold region (Yukon Territory, Canada): Evidence of weathering processes in a changing climate
Sulfate in streams and groundwater in a cold region (Yukon Territory, Canada): Evidence of weathering processes in a changing climate Open
Analyses of the sulfur (S) and oxygen (O) stable isotope ratios (δ34SSO4 and δ18OSO4) of dissolved sulfate in streams and groundwater in Yukon Territory (YT, Canada) indicates that the dominant source of this major ion is oxidation of sulf…
View article: Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer Open
Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
View article: Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer Open
The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis specifically in cancer cells with little effect on normal cells. We have previously shown that TRAIL signaling is altered in most ovarian cancer patients…
View article: Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer Open
Supplementary Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
View article: Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer
Data from Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer Open
The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis specifically in cancer cells with little effect on normal cells. We have previously shown that TRAIL signaling is altered in most ovarian cancer patients…
View article: Surface Features of As-built Metal Additive AlSi7Mg0.6
Surface Features of As-built Metal Additive AlSi7Mg0.6 Open
Additive manufacturing (AM) technologies show potential for the development of functionally integrated lightweight designs, biomimetic structures and material savings. Typically, as-built surfaces show powder particle agglomerations and re…
View article: Surface Features of As-built Metal Additive AlSi7Mg0.6
Surface Features of As-built Metal Additive AlSi7Mg0.6 Open
Additive manufacturing (AM) technologies show potential for the development of functionally integrated lightweight designs, biomimetic structures and material savings. Typically, as-built surfaces show powder particle agglomerations and re…
View article: Surface and Bulk Quality of Metal Additive AlSi7Mg0.6 With Contour Scan Variation
Surface and Bulk Quality of Metal Additive AlSi7Mg0.6 With Contour Scan Variation Open
Metal additive manufacturing technologies have large potential for future use in load bearing aerospace applications, requiring a deeper understanding of mechanical performance and influencing factors. The objective of this study is to man…
View article: CCDC 2183900: Experimental Crystal Structure Determination
CCDC 2183900: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Consecutive Multicomponent Coupling-Addition Synthesis and Chromophore Characteristics of Cyclohexene-Embedded Merocyanines and Cyanines
Consecutive Multicomponent Coupling-Addition Synthesis and Chromophore Characteristics of Cyclohexene-Embedded Merocyanines and Cyanines Open
Merocyanines with embedded butadiene structure in a cyclohexane scaffold are readily obtained by consecutive three-component alkynylation-addition sequences in moderate to excellent yield. Moreover, employing pyrrolidine as an amine provid…
View article: Investigation of the Microstructure and Properties of Aluminum–Copper Compounds Fabricated by the High-Pressure Die Casting Process
Investigation of the Microstructure and Properties of Aluminum–Copper Compounds Fabricated by the High-Pressure Die Casting Process Open
The material combination of aluminum and copper is increasingly coming into focus, especially for electrical contact applications. Investigations of different casting processes show that a significant influence for the formation of a mater…
View article: Fugitive Gas Migration in the Vadose Zone at an Experimental Field Site in the Montney Shale Gas Region
Fugitive Gas Migration in the Vadose Zone at an Experimental Field Site in the Montney Shale Gas Region Open
Supplementary information for GRL manuscript
View article: Adenosine kinase (ADK) inhibition with ABT-702 induces ADK protein degradation and a distinct form of sustained cardioprotection
Adenosine kinase (ADK) inhibition with ABT-702 induces ADK protein degradation and a distinct form of sustained cardioprotection Open
Pharmacological inhibition of adenosine kinase (ADK), the major route of myocardial adenosine metabolism, can elicit acute cardioprotection against ischemia-reperfusion (IR) by increasing adenosine signaling. Here, we identified a novel, e…