Bernd Stratmann
YOU?
Author Swipe
Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice Open
The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, while treatment options are inadequate. Hypertension and obesity-related metabolic dysfunction contribute to HFpEF. Nitro-oleic acid (NO 2 -OA) impacts…
IAPP - oligomerisation levels in plasma of people with type 2 diabetes Open
Islet amyloid polypeptide (IAPP) is co-secreted with insulin from pancreatic ß-cells. Its oligomerisation is regarded as disease driving force in type 2 diabetes (T2D) pathology. Up to now, IAPP oligomers have been detected in affected tis…
Maladaptive response following glucose overload in <span>GLUT4</span> ‐overexpressing <span>H9C2</span> cardiomyoblasts Open
Background Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic acid pathway. However, it is still unknown how cells could overcome massive chronic glucose influx on cellular and structural level. Methods/Material…
View article: Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction
Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction Open
Prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, while treatment options are inadequate. Hypertension and obesity-related metabolic dysfunctions contribute to HFpEF progression. Nitro-oleic acid (NO 2 -OA…
Chronic Hyperglycaemia Inhibits Tricarboxylic Acid Cycle in Rat Cardiomyoblasts Overexpressing Glucose Transporter Type 4 Open
An oversupply of nutrients with a loss of metabolic flexibility and subsequent cardiac dysfunction are hallmarks of diabetic cardiomyopathy. Even if excess substrate is offered, the heart suffers energy depletion as metabolic fluxes are di…
Dicarbonyl Stress in Diabetic Vascular Disease Open
Late vascular complications play a prominent role in the diabetes-induced increase in morbidity and mortality. Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisat…
Peripheral oscillometric arterial performance does not depict coronary status in patients with type 2 diabetes mellitus Open
Background Arterial stiffness is associated with cardiovascular events. Matrix metalloproteases (MMPs), their tissue inhibitors (TIMPs) and galectin-3 are involved in the pathogenesis of end organ damage. This study aimed to evaluate the c…
Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy Open
In vivo large-area confocal laser scanning microscopy (CLSM) of the human eye using EyeGuidance technology allows a large-scale morphometric assessment of the corneal subbasal nerve plexus (SNP). Here, the SNP of a patient suffering from d…
Removing parametrized rays symplectically Open
Extracting isolated rays from a symplectic manifold result in a manifold symplectomorphic to the initial one. The same holds for higher dimensional parametrized rays under an additional condition. More precisely, let $(M,ω)$ be a symplecti…
Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers Open
ClinicalTrials.gov Identifier: NCT04205942.
Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis Open
Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We in…
Nowhere vanishing primitive of a symplectic form Open
Let $M$ be a manifold with an exact symplectic form $ω$. Then there is a nowhere vanishing primitive $β$ for $ω$, i.e. $ω=\mathrm{d}β$.
Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes Open
Background Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promote…
Invariant Kähler potentials and symplectic reduction Open
For a proper Hamiltonian action of a Lie group $G$ on a Kähler manifold $(X,ω)$ with momentum map $μ$ we show that the symplectic reduction $μ^{-1}(0)/G$ is a normal complex space. Every point in $μ^{-1}(0)$ has a $G$-stable open neighborh…
Heart failure among people with Type 2 diabetes mellitus: real‐world data of 289 954 people from a diabetes database Open
Aim Comparing people with Type 2 diabetes mellitus with and without heart failure in terms of metabolic control, therapeutic regimen and comorbidities. Methods The Prospective Diabetes Registry ( DPV ) is a longitudinal documentation syste…
Diabetes Mellitus and Autoimmune Hepatitis: Demographical and Clinical Description of a Relatively Rare Phenotype Open
We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. A total of 139 patients with diabetes and AIH were analyzed and compared to 437…
P1107Metformin epigenetically regulates tissue factor expression in diabetes Open
Inflammation, diabetes and their influence on the heart 233 mL/min, p=0.033) and myocyte diameter (28±4 to 31±5 μm, p=0.012) were increased at the end of treatment, and returned to baseline (187±81 ng/mL, 91±15 g/m 2 , 22±10%, 1065±334 mL/…
Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts Open
Hyperglycemia results in accumulation of the reactive dicarbonyl methylglyoxal (MG). Methylglyoxal is detoxified by the glyoxalase system (glyoxalase 1 and 2). The influence of glyoxalase 1 knockdown on expression of collagens 1, 3, 4, and…
Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus Open
Coronary artery disease (CAD) is a common complication of type 2 diabetes mellitus (T2D). This case-control study was done to identify metabolites with different concentrations between T2D patients with and without CAD and to characterise …
Real-World Data Collection Regarding Titration Algorithms for Insulin Glargine in Patients With Type 2 Diabetes Mellitus Open
The primary objective of this study was to collect data regarding the effectiveness of different dose titration algorithms (TAs) for optimization or initiation of basal insulin supported oral therapy (BOT) in patients with type 2 diabetes.…
Micro–RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue Factor Open
Objective— Diabetes mellitus involves vascular inflammatory processes and is a main contributor to cardiovascular mortality. Notably, heightened levels of circulating tissue factor (TF) account for the increased thrombogenicity and put tho…