Explanipedia

Streptococcus cristatus reduces cariogenicity of saliva-derived microcosms under pH-dependent conditions Open

Yanling Cai, Lijing Wu, Bernd W. Brandt, M.J. Buijs, Xi Wei , et al. · 2025

S. cristatus represents a promising microbiome modulator with the potential to substantially mitigate the cariogenicity of oral microcosms.

Modelling of the Systemic Inflammatory Host Response in Relation to the Microbiome of the Endodontic Infection Open

Athina Christina Georgiou, Geert Roelof van der Ploeg, Johan A. Westerhuis, Suzette V. van der Waal, Anna Heintz‐Buschart , et al. · 2025

Aim This study aimed to investigate systemic inflammatory responses in individuals with apical periodontitis (AP) compared to age‐matched healthy controls, using advanced multiway modelling techniques. We examined associations between infl…

Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial Open

Magda Mensi, Eleonora Scotti, Silvia Marchetti, Annamaria Sordillo, G. G. Garzetti , et al. · 2025

Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer Open

Geng Xu, Yaling Jiang, Chen Sun, Bernd W. Brandt, Kamran Nazmi , et al. · 2025

Oral microbiota have been implicated in pancreatic ductal adenocarcinoma (PDAC) and may contribute to chemotherapy resistance. While previous studies attributed bacteria-induced resistance to indirect host modulation, recent findings sugge…

Oral bacterial community dynamics during induction of gingival inflammation Open

Bart J. F. Keijser, Tim J. van den Broek, Michelle van der Wurff, Remon Dulos, Ferry L P W Jagers , et al. · 2025

Introduction The human oral cavity is a complex and dynamic microbial ecosystem integral to oral and overall health. While the specific roles of microbial communities in health and disease are not fully understood, dysbiosis of the oral mi…

Salivary proteome and microbiome in pregnancy and postpartum: An exploratory study on the relation with arterial hypertension Open

Maria João Azevedo, Ana Filipa Ferreira, Dmitry S. Loginov, Petr Novák, Inês Falcão‐Pires , et al. · 2025

The salivary proteome and microbiota are shaped by AH during and after pregnancy. Further research is required to understand the underlying mechanisms impairing oral health in AH.

Clinical and Microbiological Effectiveness of Limosilactobacillus Reuteri in Supportive Periodontal Therapy: Randomized Clinical Trial Open

Magda Mensi, Eleonora Scotti, Silvia Marchetti, Annamaria Sordillo, G. G. Garzetti , et al. · 2025

Objectives The purpose of the present randomized clinical trial was to evaluate the clinical and microbiological effects of Limosilactobacillus reuteri probiotic therapy as an adjunct to Guided Biofilm Therapy (GBT) during supportive perio…

An in vitro model demonstrating homeostatic interactions between reconstructed human gingiva and a saliva-derived multispecies biofilm Open

Lin Shang, Sanne Roffel, Vera Slomka, Eleanor M. D’Agostino, Aline Métris , et al. · 2025

<i>Streptococcus mutans</i> and Caries: A Systematic Review and Meta-Analysis Open

Danuta Mazurel, Bernd W. Brandt, Martijn F. Boomsma, W. Crielaard, M.D. Lagerweij , et al. · 2025

It has been questioned whether Streptococcus mutans can still be considered the major etiological agent for caries. The main argument is that most evidence has been based on single-species identification. The composition of the oral microb…

Effect of Daily Vitamin C Supplementation with or Without Flavonoids on Periodontal, Microbial, and Systemic Conditions Before and After Periodontal Therapy: A Case Series from an RCT Open

Thijs M. H. de Jong, Eleni Stamatelou, NAM Rosema, Ineke D.C. Jansen, Bernd W. Brandt , et al. · 2024

Purpose: To investigate the effect of vitamin C supplementation with or without flavonoids on periodontal conditions, and microbial and systemic variables before and after non-surgical periodontal treatment (NSPT). Materials and Methods: A…

Oral microbial changes, oral mucositis and febrile neutropenia during myelosuppressive chemotherapy in patients diagnosed with a solid tumor or lymphoma Open

Judith A. E. M. Zecha, Judith E. Raber‐Durlacher, Bernd W. Brandt, M.J. Buijs, Egija Zaura , et al. · 2024

Objectives To evaluate the possible changes of the oral microbiome during myelosuppressive chemotherapy (CT) and to investigate the potential relationship between the oral microbiome, the presence of oral mucositis (OM) and febrile neutrop…

Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis Open

Geert Roelof van der Ploeg, Bernd W. Brandt, Bart J. F. Keijser, Monique H. van der Veen, C.M.C. Volgenant , et al. · 2024

Gingivitis-the inflammation of the gums-is a reversible stage of periodontal disease. It is caused by dental plaque formation due to poor oral hygiene. However, gingivitis susceptibility involves a complex set of interactions between the o…

The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study Open

Davis R. Zakis, Bernd W. Brandt, Suzette V. van der Waal, Bart J. F. Keijser, Wim Crielaard , et al. · 2024

The effects on the oral microbiota were sweetener dependant with the most pronounced effect on plaque microbiota. Inulin exhibited the strongest microbial modulating potential of the sweeteners tested. Further full-scale clinical studies a…

FAIR compliant database development for human microbiome data samples Open

Mathieu Dorst, Nathan Zeevenhooven, Rory Wilding, Daniel R. Mende, Bernd W. Brandt , et al. · 2024

Introduction Sharing microbiome data among researchers fosters new innovations and reduces cost for research. Practically, this means that the (meta)data will have to be standardized, transparent and readily available for researchers. The …

Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis Open

Geert Roelof van der Ploeg, Bernd W. Brandt, Bart J. F. Keijser, Monique H. van der Veen, C.M.C. Volgenant , et al. · 2024

Gingivitis - the inflammation of the gums - is a reversible stage of periodontal disease. It is caused by dental plaque formation due to poor oral hygiene. However, gingivitis susceptibility involves a complex set of interactions between t…

A new approach to describe the taxonomic structure of microbiome and its application to assess the relationship between microbial niches Open

Vincent Y. Pappalardo, Leyla Azarang, Egija Zaura, Bernd W. Brandt, Renée X. de Menezes · 2024

Next steps in studying host-microbiome interactions in apical periodontitis Open

Athina Christina Georgiou, Bernd W. Brandt, Suzette V. van der Waal · 2023

OPINION article Front. Oral. Health, 01 December 2023Sec. Oral Infections and Microbes Volume 4 - 2023 | https://doi.org/10.3389/froh.2023.1309170

Differential Modulation of Saliva-Derived Microcosm Biofilms by Antimicrobial Peptide LL-31 and D-LL-31 Open

Kahena Rodrigues Soldati, Yaling Jiang, Bernd W. Brandt, R.A.M. Exterkate, Mark J. Buijs , et al. · 2023

Microbiome modulation, aiming to restore a health-compatible microbiota, is a novel strategy to treat periodontitis. This study evaluated the modulation effects of antimicrobial peptide LL-31 and its D-enantiomer (D-LL-31) on saliva-derive…

Salivary microbiome profiles of oral cancer patients analyzed before and after treatment Open

Anna Mäkinen, Vincent Y. Pappalardo, M.J. Buijs, Bernd W. Brandt, Antti Mäkitie , et al. · 2023

Microbial communities associated with landfarming amendments during bioremediation of crude oil in Niger Delta soils Open

Paul Iturbe-Espinoza, David M. Brown, James T. Weedon, Martin Braster, Bernd W. Brandt , et al. · 2023

Landfarming is a widely utilized process that involves using bacterial biodegradation to remediate contaminated soil resulting from oil spillages. Its effectiveness can be improved using amendments that include fertilizers, biosurfactants,…

Correlating the succession of microbial communities from Nigerian soils to petroleum biodegradation Open

Paul Iturbe-Espinoza, Matthijs Bonte, James T. Weedon, Martin Braster, Bernd W. Brandt , et al. · 2023

The effect of sex steroid hormones on the ecology of in vitro oral biofilms Open

Pilar Cornejo Ulloa, Monique H. van der Veen, Bernd W. Brandt, Mark J. Buijs, Bastiaan P. Krom · 2023

The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance Open

Maria João Azevedo, A. Martín García, Carolina F. F. A. Costa, Ana Filipa Ferreira, Inês Falcão‐Pires , et al. · 2023

The mother represents one of the earliest sources of microorganisms to the child, influencing the acquisition and establishment of its microbiota in early life. However, the impact of the mother on the oral microbiota of the child from ear…

Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries Open

Dono Kahharova, Vincent Y. Pappalardo, Mark J. Buijs, Renée X. de Menezes, Mathilde C. Peters , et al. · 2023

Dental caries lesions are a clinical manifestation of disease, preceded by microbial dysbiosis, which is poorly characterized and thought to be associated with saccharolytic taxa. Here, we assessed the associations between the oral microbi…

Host–microbiome interactions in apical periodontitis: The endodontic microbiome in relation to circulatory immunologic markers Open

Athina Christina Georgiou, Suzette V. van der Waal, M.J. Buijs, Wim Crielaard, Egija Zaura , et al. · 2023

Aim To explore microbial differences in the endodontic infection of teeth with primary or secondary apical periodontitis (AP), with or without symptomatology. Additionally, to investigate if these differences are depicted in immunologic ma…

Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem Open

Rob J. M. van Spanning, Qingtian Guan, Chrats Melkonian, James Gallant, Lùbos Polerecký , et al. · 2022

Dysbiosis and predicted function of dental and ruminal microbiome associated with bovine periodontitis Open

Ana Carolina Borsanelli, Flávia Regina Florencio de Athayde, Marcello P. Riggio, Bernd W. Brandt, Fernando Igne Rocha , et al. · 2022

Extensive cattle livestock is advancing in Amazonia and its low productivity, with consequent pressure to open new areas, is partly due to sanitary problems and, among them, the periodontal diseases, whose environmental triggers or modifyi…

Correlating biodegradation kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the dynamics of microbial communities originating from soil in Vietnam contaminated with herbicides and dioxins Open

Thị Lan Anh Nguyen, Ha Thi Cam Dang, Ton That Huu Dat, Bernd W. Brandt, Wilfred F. M. Röling , et al. · 2022

We studied the succession of bacterial communities during the biodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The communities originated from a mesocosm with soil from Bien Hoa airbase in Vietnam heavily contaminated …

Oil Absorbent Polypropylene Particles Stimulate Biodegradation of Crude Oil by Microbial Consortia Open

Madalina M. Vita, Paul Iturbe-Espinoza, Matthijs Bonte, Bernd W. Brandt, Martin Braster , et al. · 2022

Oil absorbent particles made from surface-modified polypropylene can be used to facilitate the removal of oil from the environment. In this study, we investigated to what extent absorbed oil was biodegraded and how this compared to the bio…

The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial Open

C.M.C. Volgenant, Suzette V. van der Waal, Bernd W. Brandt, M.J. Buijs, Monique H. van der Veen , et al. · 2022

Introduction In the current study, we evaluated the effectiveness of two well-defined probiotic strains, Lactobacillus paracasei LPc-G110 (CCTCC M 2013691) and Lactobacillus plantarum GOS42 (DSM 32131), during an experimental gingivitis ch…

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