Bernhard A. Schrefler
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View article: Computational Modelling of Cancer Nanomedicine: Integrating Hyperthermia Treatment Into a Multiphase Porous‐Media Tumour Model
Computational Modelling of Cancer Nanomedicine: Integrating Hyperthermia Treatment Into a Multiphase Porous‐Media Tumour Model Open
Heat‐based cancer treatment, so‐called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy or radiation therapy. To apply heat locally, iron oxide nanoparticles are injected into the …
View article: Hybrid FEM-Peridynamic Modelling of Supershear Earthquake Ruptures
Hybrid FEM-Peridynamic Modelling of Supershear Earthquake Ruptures Open
During earthquakes, seismic ruptures propagate (Vr) along faults as mode II-III cracks, approaching the shear wave speed Vs (i.e., sub-Rayleigh or Vr ~ 0.9 Vs), or, in at least 15% cases, at Vr faster than Vs (i.e., supershear or Vr ~ W…
View article: Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model
Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model Open
Heat-based cancer treatment, so-called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy or radiation therapy. To apply heat locally, iron oxide nanoparticles are injected into the …
View article: Matrix‐based implementation and GPU acceleration of hybrid FEM and peridynamic model for hydro‐mechanical coupled problems
Matrix‐based implementation and GPU acceleration of hybrid FEM and peridynamic model for hydro‐mechanical coupled problems Open
The hybrid finite element‐peridynamic (FEM‐PD) models have been evidenced for their exceptional ability to address hydro‐mechanical coupled problems involving cracks. Nevertheless, the non‐local characteristics of the PD equations and the …
View article: Mode I sub- and super-shear rupture and forerunning in porous media
Mode I sub- and super-shear rupture and forerunning in porous media Open
Numerical simulations demonstrate the occurrence of both sub- and supershear ruptures in dry and saturated porous media during mode I fracture. Initially, the Finite Element Method is applied to investigate a case of sub-shear velocity in …
View article: Issue Information
Issue Information Open
The International Journal for Numerical Methods in Engineering publishes original papers describing significant, novel developments in numerical methods that are applicable to engineering problems.The Journal is known for welcoming contrib…
View article: An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow Open
One of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side …
View article: Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes Open
The association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluid…
View article: On stepwise advancement of fractures and pressure oscillations in saturated porous media
On stepwise advancement of fractures and pressure oscillations in saturated porous media Open
Comments to K.M. Pervaiz Fathima, René de Borst, Implications of single or multiple pressure degrees of freedom at fracture in fluid saturated porous media, Engineering Fracture Mechanics, 213 (2019), 1-20.
View article: Machine Learning Instructed Microfluidic Synthesis of Curcumin-loaded Liposomes
Machine Learning Instructed Microfluidic Synthesis of Curcumin-loaded Liposomes Open
The association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluid…
View article: Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment
Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment Open
To unravel processes that lead to the growth of solid tumours, it is necessary to link knowledge of cancer biology with the physical properties of the tumour and its interaction with the surrounding microenvironment. Our understanding of t…
View article: Global sensitivity analysis based on Gaussian‐process metamodelling for complex biomechanical problems
Global sensitivity analysis based on Gaussian‐process metamodelling for complex biomechanical problems Open
Biomechanical models often need to describe very complex systems, organs or diseases, and hence also include a large number of parameters. One of the attractive features of physics‐based models is that in those models (most) parameters hav…
View article: Tumour growth: Bayesian parameter calibration of a multiphase porous media model based on <i>in vitro</i> observations of Neuroblastoma spheroid growth in a hydrogel microenvironment
Tumour growth: Bayesian parameter calibration of a multiphase porous media model based on <i>in vitro</i> observations of Neuroblastoma spheroid growth in a hydrogel microenvironment Open
To unravel processes that lead to the growth of solid tumours, it is necessary to link knowledge of cancer biology with the physical properties of the tumour and its interaction with the surrounding microenvironment. Our understanding of t…
View article: Multiscale thermoelastic modelling of composite strands using the “fundamental solutions” method
Multiscale thermoelastic modelling of composite strands using the “fundamental solutions” method Open
A novel computationally effective approach to multiscale thermoelastic modelling of composite structures and its application to a thermomechanical analysis of two ITER superconducting strands is presented. Homogenisation and recovering pro…
View article: Issue Information
Issue Information Open
The International Journal for Numerical Methods in Engineering publishes original papers describing significant, novel developments in numerical methods that are applicable to engineering problems.The Journal is known for welcoming contrib…
View article: Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems
Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems Open
Biomechanical models often need to describe very complex systems, organs or diseases, and hence also include a large number of parameters. One of the attractive features of physics-based models is that in those models (most) parameters hav…
View article: A <scp>CBS</scp>‐type stabilizing algorithm for the consolidation of saturated porous media
A <span>CBS</span>‐type stabilizing algorithm for the consolidation of saturated porous media Open
While deriving the theoretical part of paper [1] again for chapter 5 in the book "Computational Geomechanics: Theory and Applications", Second Edition, with authors A. Chan, M. Pastor, B. Schrefler, T. Shiomi, O. C. Zienkiewicz, ISBN978111…
View article: Mehrfeld- und mehrskalige rechnerunterstützte Bruchmechanik und maschinell lernende Materialmodellierung
Mehrfeld- und mehrskalige rechnerunterstützte Bruchmechanik und maschinell lernende Materialmodellierung Open
Fracture mechanics counts to the most emerging and promising fields of engineering mechanics. In the last few decades, the topics of crack initiation and propagation in solid and porous materials have attracted numerous theoretical, experi…
View article: Elucidating the Role of Matrix Porosity and Rigidity in Glioblastoma Type IV Progression
Elucidating the Role of Matrix Porosity and Rigidity in Glioblastoma Type IV Progression Open
The highly infiltrating nature of glioma cells is the major cause for the poor prognosis of brain malignancies. Motility, proliferation, and gene expression of cells in natural and synthetic gels have been analyzed by several authors, yet …
View article: Averaging theory for description of environmental problems: What have we learned?
Averaging theory for description of environmental problems: What have we learned? Open
Advances in Water Resources has been a prime archival source for implementation of averaging theories in changing the scale at which processes of importance in environmental modeling are described. Thus in celebration of the 35th year of t…