Bernhard Baumann
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View article: Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex
Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex Open
The retinal phenotype of Alzheimer’s disease (AD), its connection to spatial memory, and the influence of sex on the phenotype are poorly understood. Here, we investigate the retina and spatial memory of 5xFAD mouse models of AD by measuri…
View article: Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography
Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography Open
The cornea is constantly exposed to cardio-pulmonary induced changes of intraocular pressure. Resulting pulsatile motion patterns in the eye may indicate severe pathological alterations of the biomechanical composition and the physiologica…
View article: Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex
Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex Open
Significance The retinal phenotype of Alzheimer’s disease (AD) is poorly understood. The connection between spatial memory and retinal phenotype is poorly investigated. Additionally, the influence of sex on the disease in mouse models is n…
View article: Alzheimer’s disease neuropathological change in younger individuals with IDH-mutant glioma
Alzheimer’s disease neuropathological change in younger individuals with IDH-mutant glioma Open
Background With aging populations, the incidence of brain tumors and neurodegenerative diseases is rising. Recently, Alzheimer’s disease neuropathological change (ADNC) has been documented in the tumor-adjacent cortex of 50% of patients wi…
View article: Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina
Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina Open
In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomogr…
View article: Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts
Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts Open
Our study presents a simple yet cost-effective technique to mitigate birefringence-related artifacts in OCT imaging. This method can be readily implemented in existing OCT technology and improve the effectiveness of various OCT imaging app…
View article: P25.02.A GLIOBLASTOMA RESEARCH FROM 1938 TO 2021: INCREASED SURVIVAL, CHANGING TREATMENT REGIMES, AND GENDER DISPARITIES IN AUTHORSHIP
P25.02.A GLIOBLASTOMA RESEARCH FROM 1938 TO 2021: INCREASED SURVIVAL, CHANGING TREATMENT REGIMES, AND GENDER DISPARITIES IN AUTHORSHIP Open
BACKGROUND Glioblastoma is the most common and aggressive malignant brain tumor in adults with continued poor prognosis. While the long-lasting gold standard RT-TMZ was eventually refined by incorporating tumor treating fields as well as l…
View article: P18.42.B TAU AND AMYLOID BETA PATHOLOGY IN IDH-MUTANT GLIOMA
P18.42.B TAU AND AMYLOID BETA PATHOLOGY IN IDH-MUTANT GLIOMA Open
BACKGROUND With an aging population the incidence of brain tumors and neurodegenerative diseases is increasing. Although biological associations between glioma and Alzheimer’s disease (AD) have been suggested, the frequency of comorbidity …
View article: Frequent Alzheimer’s disease neuropathological change in patients with glioblastoma
Frequent Alzheimer’s disease neuropathological change in patients with glioblastoma Open
Background The incidence of brain cancer and neurodegenerative diseases is increasing with a demographic shift towards aging populations. Biological parallels have been observed between glioblastoma and Alzheimer’s disease (AD), which conv…
View article: Deep learning links localized digital pathology phenotypes with transcriptional subtype and patient outcome in glioblastoma
Deep learning links localized digital pathology phenotypes with transcriptional subtype and patient outcome in glioblastoma Open
Background Deep learning has revolutionized medical image analysis in cancer pathology, where it had a substantial clinical impact by supporting the diagnosis and prognostic rating of cancer. Among the first available digital resources in …
View article: Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy
Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy Open
Purpose To compare detection rates of microaneurysms (MAs) on high‐speed megahertz optical coherence tomography angiography (MHz‐OCTA), fluorescein angiography (FA) and colour fundus photography (CF) in patients with diabetic retinopathy (…
View article: NCMP-15. AMYLOID-BETA AND TAU-PATHOLOGY IN THE GLIOMA VICINITY
NCMP-15. AMYLOID-BETA AND TAU-PATHOLOGY IN THE GLIOMA VICINITY Open
With aging societies the incidences of brain cancer and neurodegenerative disease are increasing. Although biological associations were suggested between glioma and Alzheimer's disease (AD), the rate of comorbidity is ill-defined. We here …
View article: Editorial: In vivo retinal imaging in animal models
Editorial: In vivo retinal imaging in animal models Open
EDITORIAL article Front. Ophthalmol., 23 October 2023Sec. Retina Volume 3 - 2023 | https://doi.org/10.3389/fopht.2023.1309894
View article: Polarization-insensitive optical coherence tomography based on partly depolarized light
Polarization-insensitive optical coherence tomography based on partly depolarized light Open
Polarization-related image artifacts are frequently observed in optical coherence tomography (OCT) data. As most modern OCT layouts rely on polarized light sources, only the co-polarized component of the light scattered from within a sampl…
View article: Polymer-derived Ni/SiOC materials structured by vat-based photopolymerization with catalytic activity in CO2 methanation
Polymer-derived Ni/SiOC materials structured by vat-based photopolymerization with catalytic activity in CO2 methanation Open
A new concept for the additive manufacturing of nickel-modified polymer-derived ceramics via vat-based photopolymerization is presented. A photoactive polysiloxane resin system modified by nickel nitrate via methacrylic acid complexation w…
View article: Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma
Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma Open
Background The prognostic roles of clinical and laboratory markers have been exploited to model risk in patients with primary CNS lymphoma, but these approaches do not fully explain the observed variation in outcome. To date, neuroimaging …
View article: Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research—A Review
Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research—A Review Open
The zebrafish is an established vertebrae model in the field of biomedical research. With its small size, rapid maturation time and semi-transparency at early development stages, it has proven to be an important animal model, especially fo…
View article: EPCO-15. LINKING HISTOLOGICAL GLIOBLASTOMA PHENOTYPES TO TRANSCRIPTIONAL SUBTYPES AND PROGNOSIS USING DEEP LEARNING
EPCO-15. LINKING HISTOLOGICAL GLIOBLASTOMA PHENOTYPES TO TRANSCRIPTIONAL SUBTYPES AND PROGNOSIS USING DEEP LEARNING Open
Deep learning is increasingly utilized in medical image analysis and shows promise to substantially inform treatment decisions in clinical practice. While it finds broad applications in radiology or genomics, there are still relatively few…
View article: Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1<sup>−/−</sup> Mice Using Intensity, Polarization, and Spectroscopic OCT
Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1<sup>−/−</sup> Mice Using Intensity, Polarization, and Spectroscopic OCT Open
These biomarkers were designed with the potential for rapid adoption by existing clinical OCT systems without requiring new hardware.
View article: OS02.5.A Alzheimer-type neuropathological changes in glioblastoma-adjacent cortex
OS02.5.A Alzheimer-type neuropathological changes in glioblastoma-adjacent cortex Open
Background Glioblastoma (GBM) is an aggressive type of brain cancer that is prevalent and fatal in the elderly. Age is not only the most common risk factor for brain cancer but also for neurodegenerative diseases, and previous studies have…
View article: Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography
Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography Open
Breast cancer is a leading cause of death in female patients worldwide. Further research is needed to get a deeper insight into the mechanisms involved in the development of this devastating disease and to find new therapy strategies. The …
View article: The Digital Brain Tumour Atlas, an open histopathology resource
The Digital Brain Tumour Atlas, an open histopathology resource Open
Currently, approximately 150 different brain tumour types are defined by the WHO. Recent endeavours to exploit machine learning and deep learning methods for supporting more precise diagnostics based on the histological tumour appearance h…
View article: Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography
Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography Open
Cataracts are the leading cause of blindness worldwide. Here we propose optical coherence tomography (OCT) as a quantitative method for investigating cataracts. OCT provides volumetric and non-invasive access to the lens and makes it possi…
View article: Reconstruction of visible light optical coherence tomography images retrieved from discontinuous spectral data using a conditional generative adversarial network
Reconstruction of visible light optical coherence tomography images retrieved from discontinuous spectral data using a conditional generative adversarial network Open
Achieving high resolution in optical coherence tomography typically requires the continuous extension of the spectral bandwidth of the light source. This work demonstrates an alternative approach: combining two discrete spectral windows lo…
View article: Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths
Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths Open
Currently, the cochlear implantation procedure mainly relies on using a hand lens or surgical microscope, where the success rate and surgery time strongly depend on the surgeon’s experience. Therefore, a real-time image guidance tool may f…
View article: High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice
High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice Open
Vascular leakage plays a key role in vision-threatening retinal diseases such as diabetic retinopathy and age-related macular degeneration. Fluorescence angiography is the current gold standard for identification of leaky vasculature in vi…