Bernhard Brüne
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View article: Ferroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids
Ferroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids Open
Glioblastoma is one of the most aggressive and therapeutically challenging brain tumors. It is characterized by a highly immunosuppressive tumor microenvironment and poor prognosis, requiring novel treatment strategies. Along this line, fe…
View article: S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation
S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation Open
Background Sphingosine-1-phosphate (S1P) and its five receptors S1PR1-5 play an essential role in the migration, differentiation and activation of various immune cells. Several S1PR modulators with distinct selectivity have been recently a…
View article: The role of type I interferon signaling in myeloid anti-tumor immunity
The role of type I interferon signaling in myeloid anti-tumor immunity Open
Tumors often arise in chronically inflamed, and thus immunologically highly active niches. While immune cells are able to recognize and remove transformed cells, tumors eventually escape the control of the immune system by shaping their im…
View article: RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling Open
Arachidonate 15-lipoxygenase type B (ALOX15B) peroxidises polyunsaturated fatty acids to their corresponding fatty acid hydroperoxides, which are subsequently reduced into hydroxy-fatty acids. A dysregulated abundance of these biological l…
View article: Inflammation in a ferroptotic environment
Inflammation in a ferroptotic environment Open
Ferroptosis is an iron-dependent form of cell death, which finally culminates in lipid peroxidation and membrane damage. During the past decade, the interest in ferroptosis increased substantially and various regulatory components were dis…
View article: Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort. Supplementary Table S2 shows the inventory of available materials and molecular analyses. Supplementary Table S3 shows the selected variant types for whole e…
View article: Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Data from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Data from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
In colorectal cancers (CRC) the tumor microenvironment plays a key role for prognosis and therapy efficacy. Patient-derived tumor organoids (PDTOs) show enormous potential for preclinical testing, however, cultured tumor cells lose importa…
View article: Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort. Supplementary Table S2 shows the inventory of available materials and molecular analyses. Supplementary Table S3 shows the selected variant types for whole e…
View article: Corrigendum: Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells
Corrigendum: Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells Open
[This corrects the article DOI: 10.3389/fimmu.2022.906127.].
View article: Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities Open
Human arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fat…
View article: ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2 Open
Macrophage cholesterol homeostasis is crucial for health and disease and has been linked to the lipid-peroxidizing enzyme arachidonate 15-lipoxygenase type B (ALOX15B), albeit molecular mechanisms remain obscure. We performed global transc…
View article: Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging
Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging Open
Protein persulfidation is a significant post-translational modification that involves addition of a sulfur atom to the cysteine thiol group and is facilitated by sulfide species. Persulfidation targets reactive cysteine residues within pro…
View article: Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation Open
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase…
View article: Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression
Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression Open
Macrophages are a highly versatile and heterogenic group of immune cells, known for their involvement in inflammatory reactions. However, our knowledge about distinct subpopulations of macrophages and their specific contribution to the res…
View article: SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism
SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism Open
Burkitt lymphoma cells (BL) exploit antigen-independent tonic signals transduced by the B cell antigen receptor (BCR) for their survival, but the molecular details of the rewired BLspecific BCR signal network remain unclear. A loss of func…
View article: Data from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Data from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses Open
In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important char…
View article: Supplementary Figures 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Supplementary Figures 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Supplementary Figures 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Supplementary Figures 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Supplementary Tables 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Supplementary Tables 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses Open
Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort. Supplementary Table S2 shows the inventory of available materials and molecular analyses. Supplementary Table S3 shows the selected variant types for whole e…
View article: Data from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Data from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses Open
In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important char…