Bernhard Fleckenstein
YOU?
Author Swipe
View article: The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication
The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication Open
Herpesvirus saimiri (HVS), a T-lymphotropic tumor virus of neotropical primates, and the Kaposi's sarcoma-associated human herpesvirus 8 (KSHV) belong to the gamma-2-herpesvirus (Rhadinovirus) subfamily and share numerous features of genom…
View article: Data from Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy
Data from Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy Open
Purpose:If routine diagnostics are inconclusive, neurologic deterioration and death of patients with brain cancer are attributed to tumor or therapy. Therefore, diagnosing symptoms of encephalopathy caused by human cytomegalovirus (HCMV) r…
View article: Supplementary Data from Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy
Supplementary Data from Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy Open
Supplementary Table 1
View article: Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency Open
Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). C…
View article: Alternative NF-κB Signaling Discriminates Induction of the Tumor Marker Fascin by the Viral Oncoproteins Tax-1 and Tax-2 of Human T-Cell Leukemia Viruses
Alternative NF-κB Signaling Discriminates Induction of the Tumor Marker Fascin by the Viral Oncoproteins Tax-1 and Tax-2 of Human T-Cell Leukemia Viruses Open
Transcriptional regulation of the actin-bundling protein and tumor marker Fascin is highly diverse depending on cell and tumor type. Previously, we discovered that the viral oncoprotein Tax-1 of human T-cell leukemia virus type 1 (HTLV-1) …
View article: Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation
Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation Open
The human T-cell leukemia virus type 1 (HTLV-1)-encoded transactivator and oncoprotein Tax-1 is essential for HTLV-1 replication. We recently found that Tax-1 interacts with transcription elongation factor for RNA polymerase II 2, ELL2, wh…
View article: High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency Open
We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacteri…
View article: Inherited human IFN-γ deficiency underlies mycobacterial disease
Inherited human IFN-γ deficiency underlies mycobacterial disease Open
Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by a selective predisposition to clinical disease caused by the Bacille Calmette-Guérin (BCG) vaccine and environmental mycobacteria. The known genetic etiologies of…
View article: Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common <i>TYK2</i> missense variant
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common <i>TYK2</i> missense variant Open
Homozygosity for the P1104A missense variant of the TYK2 Janus kinase is common monogenic etiology of primary tuberculosis.
View article: Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23
Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23 Open
Human IFN-γ–dependent immunity to mycobacteria is less compromised in IL-12Rβ2 or IL-23R deficiency than IL-12Rβ1 deficiency.
View article: EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency
EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency Open
Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced lymphopr…
View article: ZNF341 controls STAT3 expression and thereby immunocompetence
ZNF341 controls STAT3 expression and thereby immunocompetence Open
Homozygous nonsense mutations in ZNF341 impair its ability to activate STAT3 transcription and thereby cause immunodeficiency.
View article: A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity Open
ZNF341 is a newly characterized transcription factor controlling baseline and inducible transcription of the human STAT3 gene.
View article: Dual T cell– and B cell–intrinsic deficiency in humans with biallelic <i>RLTPR</i> mutations
Dual T cell– and B cell–intrinsic deficiency in humans with biallelic <i>RLTPR</i> mutations Open
Combined immunodeficiency (CID) refers to inborn errors of human T cells that also affect B cells because of the T cell deficit or an additional B cell–intrinsic deficit. In this study, we report six patients from three unrelated families …
View article: Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans
Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans Open
The nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NF-κB1) is a master regulator of immune and inflammatory responses.[1][1],[2][2] NF-κB1 belongs to the NF-κB/Rel family of transcription factors that consists of fiv…
View article: Frequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain
Frequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain Open
CMV reactivation frequently causes encephalopathy during radio(chemo)therapy of the brain. The unexpected high incidence of this infection makes it highly clinically relevant for every treating physician.
View article: Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease Open
Autoimmune lymphoproliferative syndrome is frequently caused by mutations in genes involved in the Fas death receptor pathway, but for 20-30% of patients the genetic defect is unknown. We observed that treatment of healthy T cells with int…