Bernhard Kaltenboeck
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View article: <i>Chlamydia trachomatis</i> Seroassays Used in Epidemiologic Research: A Narrative Review and Practical Considerations
<i>Chlamydia trachomatis</i> Seroassays Used in Epidemiologic Research: A Narrative Review and Practical Considerations Open
Chlamydia trachomatis (CT) is a sexually transmitted infection that can lead to adverse reproductive health outcomes. CT prevalence estimates are primarily derived from screening using nucleic acid amplification tests (NAATs). However, scr…
View article: Comparative Evaluation of GS-441524, Teriflunomide, Ruxolitinib, Molnupiravir, Ritonavir, and Nirmatrelvir for In Vitro Antiviral Activity against Feline Infectious Peritonitis Virus
Comparative Evaluation of GS-441524, Teriflunomide, Ruxolitinib, Molnupiravir, Ritonavir, and Nirmatrelvir for In Vitro Antiviral Activity against Feline Infectious Peritonitis Virus Open
Feline infectious peritonitis (FIP), caused by feline coronavirus (FcoV), is considered one of the most enigmatic diseases in cats. Developing effective drugs for FIP is crucial due to its global prevalence and severity. In this study, six…
View article: Peptide ELISA and FRET-qPCR Identified a Significantly Higher Prevalence of Chlamydia suis in Domestic Pigs Than in Feral Swine from the State of Alabama, USA
Peptide ELISA and FRET-qPCR Identified a Significantly Higher Prevalence of Chlamydia suis in Domestic Pigs Than in Feral Swine from the State of Alabama, USA Open
Chlamydia suis is an important, highly prevalent, and diverse obligate intracellular pathogen infecting pigs. In order to investigate the prevalence and diversity of C. suis in the U.S., 276 whole blood samples from feral swine were collec…
View article: Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA
Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA Open
Background The main vector and reservoir host of Rickettsia felis, an emerging human pathogen causing flea-borne spotted fever, is the cat flea Ctenocephalides felis . While cats have not been found to be infected with the organism, signif…
View article: Mucosal Vaccination with UV-Inactivated Chlamydia suis in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ+ Effector Memory Cells
Mucosal Vaccination with UV-Inactivated Chlamydia suis in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ+ Effector Memory Cells Open
Chlamydia trachomatis (Ct) infections are the most frequent bacterial sexually transmitted disease, and they can lead to ectopic pregnancy and infertility. Despite these detrimental long-term sequelae, a vaccine is not available. Success i…
View article: Comparison of microbiota, antimicrobial resistance genes and mobile genetic elements in flies and the feces of sympatric animals
Comparison of microbiota, antimicrobial resistance genes and mobile genetic elements in flies and the feces of sympatric animals Open
Flies are well-known vectors of bacterial pathogens, but there are little data on their role in spreading microbial community and antimicrobial resistance. In this study, we compared the bacterial community, antimicrobial resistance genes …
View article: Multi-peptide ELISAs overcome cross-reactivity and inadequate sensitivity of conventional Chlamydia pneumoniae serology
Multi-peptide ELISAs overcome cross-reactivity and inadequate sensitivity of conventional Chlamydia pneumoniae serology Open
View article: P855 Multi-peptide ELISAS overcome cross-reactivity and inadequate sensitivity of<i>chlamydia trachomatis</i>and<i>C. pneumoniae</i>serology
P855 Multi-peptide ELISAS overcome cross-reactivity and inadequate sensitivity of<i>chlamydia trachomatis</i>and<i>C. pneumoniae</i>serology Open
Background Chlamydia spp. serology is compromised by cross-reactivity of classical antigens. For specific detection of anti-trachomatis (Ctr) and anti-C. pneumoniae (Cpn) antibodies, we developed and validated novel pe…
View article: Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti<i>-</i>C. trachomatis Antibodies
Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti<i>-</i>C. trachomatis Antibodies Open
For detection of anti- C. trachomatis antibodies by serological assays, use of classical chlamydial antigens results in high cross-reactivity and poor sensitivity. Previously, we discovered 48 strongly reactive peptide antigens of C. trach…
View article: Discovery of Human-Specific Immunodominant <i>Chlamydia trachomatis</i> B Cell Epitopes
Discovery of Human-Specific Immunodominant <i>Chlamydia trachomatis</i> B Cell Epitopes Open
Current serological assays for species-specific detection of anti- Chlamydia species antibodies suffer from well-known shortcomings in specificity and ease of use. Due to the high prevalences of both anti- C. trachomatis and anti- C. pneum…
View article: Comprehensive Molecular Serology of Human<i>Chlamydia trachomatis</i>Infections by Peptide Enzyme-Linked Immunosorbent Assays
Comprehensive Molecular Serology of Human<i>Chlamydia trachomatis</i>Infections by Peptide Enzyme-Linked Immunosorbent Assays Open
For detection of anti- Chlamydia trachomatis antibodies by serological assays, use of classical whole-organism chlamydial antigens results in high cross-reactivity. These antigens bind mainly antibodies against the major outer membrane pro…
View article: A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera
A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera Open
View article: Asymptomatic infections with highly polymorphic Chlamydia suis are ubiquitous in pigs
Asymptomatic infections with highly polymorphic Chlamydia suis are ubiquitous in pigs Open
View article: From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen
From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen Open
View article: <i>Chlamydia gallinacea</i>: a widespread emerging <i>Chlamydia</i> agent with zoonotic potential in backyard poultry
<i>Chlamydia gallinacea</i>: a widespread emerging <i>Chlamydia</i> agent with zoonotic potential in backyard poultry Open
SUMMARY Chlamydia gallinacea , a new chlamydial agent, has been reported in four European countries as well as Argentina and China. Experimentally infected chickens with C. gallinacea in previous study showed no clinical signs but had sign…
View article: Cross-sectional quantitative RT-PCR study of feline coronavirus viremia and replication in peripheral blood of healthy shelter cats in Southern California
Cross-sectional quantitative RT-PCR study of feline coronavirus viremia and replication in peripheral blood of healthy shelter cats in Southern California Open
Objectives The objectives of this study were to determine the prevalence of feline coronavirus (FCoV) viremia, and its replication in peripheral blood using quantitative RT-PCR (qRT-PCR) methodology in a population of 205 healthy shelter c…
View article: Additional file 8: Figure S1. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen
Additional file 8: Figure S1. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen Open
Graphical representation of the predicted transmembrane helices in the analyzed putative C. gallinacea inclusion (Inc) proteins from this study. (DOCX 423Â kb)
View article: Additional file 7: Table S7. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen
Additional file 7: Table S7. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen Open
List of the predicted transmembrane helices in the analyzed putative C. gallinacea inclusion (Inc) proteins from this study. (XLSX 10Â kb)
View article: Additional file 6: Table S6. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen
Additional file 6: Table S6. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen Open
Original data for T3SS of C. gallinacea, including the locus-tags, and their annotation/putative function, length and direction. (XLS 36Â kb)
View article: Additional file 5: Table S5. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen
Additional file 5: Table S5. of From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen Open
Original data for MLST analysis of the C. gallinacea-positive samples. (XLSX 10Â kb)
View article: Detection of influenza A virus from live-bird market poultry swab samples in China by a pan-IAV, one-step reverse-transcription FRET-PCR
Detection of influenza A virus from live-bird market poultry swab samples in China by a pan-IAV, one-step reverse-transcription FRET-PCR Open
View article: Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction Open
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers typically choose …
View article: Chlamydia gallinacea, not C. psittaci, is the endemic chlamydial species in chicken (Gallus gallus)
Chlamydia gallinacea, not C. psittaci, is the endemic chlamydial species in chicken (Gallus gallus) Open
View article: Evolutionary distance from the putative <i>incA</i> ancestor correlates to virulence of <i>C. pecorum</i> strains.
Evolutionary distance from the putative <i>incA</i> ancestor correlates to virulence of <i>C. pecorum</i> strains. Open
A neighbor-joining phylogram (not shown) was constructed of the conserved 5′ portion of incA of all available C. pecorum sequences, and an outgroup composed of one incA sequence of each of the 8 remaining chlamydial sp…
View article: Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains from pigs, sheep, cattle, and koalas
Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains from pigs, sheep, cattle, and koalas Open
View article: Defining Species-Specific Immunodominant B Cell Epitopes for Molecular Serology of Chlamydia Species
Defining Species-Specific Immunodominant B Cell Epitopes for Molecular Serology of Chlamydia Species Open
Urgently needed species-specific enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies against Chlamydia spp. have been elusive due to high cross-reactivity of chlamydial antigens. To identify Chlamydia species-specif…
View article: Additional file 6: Table S4. of Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains from pigs, sheep, cattle, and koalas
Additional file 6: Table S4. of Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains from pigs, sheep, cattle, and koalas Open
C. pecorum isolates and clinical samples Additional file 4: Table S3 and Additional file 6: Table S4. (XLSX 23Â kb)