Bernhard Lendl
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View article: Fusion of incomplete QCL-IR and ECD datasets using MCR-ALS to extend the viable concentration range for studying protein denaturation
Fusion of incomplete QCL-IR and ECD datasets using MCR-ALS to extend the viable concentration range for studying protein denaturation Open
While several techniques exist to study the secondary structure of proteins, mid-IR and electronic circular dichroism spectroscopy are complementary techniques that stand out for liquid measurements due to their non-destructive nature, bro…
View article: Flow Injection-Based Refractive Index Sensing with a Si <sub>3</sub> N <sub>4</sub> Photonic Crystal Nanobeam-Microring Fano Resonator
Flow Injection-Based Refractive Index Sensing with a Si <sub>3</sub> N <sub>4</sub> Photonic Crystal Nanobeam-Microring Fano Resonator Open
INPHO
View article: Radiation-pressure-induced surface deformation of transparent liquids due to laser beams under oblique incidence
Radiation-pressure-induced surface deformation of transparent liquids due to laser beams under oblique incidence Open
We consider the deformation of transparent liquid surfaces under the influence of radiation pressure generated from a gaussian laser beam with oblique incidence. It is seen that the beam intensity cross-section at the surface becomes ellip…
View article: Time-dependent thermal lens signal with tightly focused laser beam excitation
Time-dependent thermal lens signal with tightly focused laser beam excitation Open
This work theoretically and numerically explores the effects of varying the excitation beam radius along the propagation axis on time-dependent thermal lensing phenomena. We investigate how changes in sample length and geometrical paramete…
View article: Not Just Better Resolution: A Detailed Study of the Signal Distribution in Mid-Infrared Optical Photothermal Imaging
Not Just Better Resolution: A Detailed Study of the Signal Distribution in Mid-Infrared Optical Photothermal Imaging Open
The spatial resolution of an imaging system is generally evaluated by analysis of the point spread function (PSF), that is, the system response to a point source in the object plane. The PSF, albeit a fundamental concept in light microscop…
View article: Experimental and Theoretical Insights into Nanoscale AFM-IR Imaging of Complex Heterogeneous Structures
Experimental and Theoretical Insights into Nanoscale AFM-IR Imaging of Complex Heterogeneous Structures Open
Nanoscale chemical imaging enabled by atomic force microscopy-infrared spectroscopy (AFM-IR) provides valuable insights into the complex structures and chemical compositions of materials and biological samples. While AFM-IR has been applie…
View article: Identifying Spectral Biomarkers for Migratory Potential in Cancer Cells Using FTIR and O-PTIR Spectroscopy
Identifying Spectral Biomarkers for Migratory Potential in Cancer Cells Using FTIR and O-PTIR Spectroscopy Open
Cancer is a leading cause of death worldwide, and incidence and mortality are growing rapidly. Metastasis, the occurrence of cancer at sites different from the primary tumor, can affect multiple organs, compromising their function or alter…
View article: Optical force density and surface displacements in transparent dielectrics due to nonionizing sub-picosecond laser excitation
Optical force density and surface displacements in transparent dielectrics due to nonionizing sub-picosecond laser excitation Open
The optical force density acting in transparent dielectric media due to short laser excitation is theoretically analyzed. For typical laser pulses with picosecond duration, the momentum component of the optical force becomes of the same or…
View article: Laser-based mid-IR photothermal spectroscopy of liquids: a new avenue for in-line sensing in process analytical technology
Laser-based mid-IR photothermal spectroscopy of liquids: a new avenue for in-line sensing in process analytical technology Open
Access to real-time chemical and physical information is of fundamental importance in modern producing industries, as it is needed for process monitoring and process control. It also enables process optimization, meeting regulatory require…
View article: Micro-mirror aided mid-infrared plasmonic beam combiner monolithically integrated with quantum cascade lasers and detectors
Micro-mirror aided mid-infrared plasmonic beam combiner monolithically integrated with quantum cascade lasers and detectors Open
The development of novel mid-infrared (MIR) devices and systems is crucial for addressing applications in biomedical analysis, chemical reaction-monitoring, or high-bitrate free-space telecommunication. Combining multiple functional elemen…
View article: Investigating the influence of process parameters on the properties and refolding yield of single-chain variable fragment inclusion bodies
Investigating the influence of process parameters on the properties and refolding yield of single-chain variable fragment inclusion bodies Open
Ever since the potential of inclusion bodies (IBs) has been recognized, substantial advances have been made towards understanding IB processes and enabling efficient and controlled development strategies. Still, the influence of the chosen…
View article: Method for Mid-IR Spectroscopy of Extracellular Vesicles at the Subvesicle Level
Method for Mid-IR Spectroscopy of Extracellular Vesicles at the Subvesicle Level Open
Extracellular vesicles (EVs) are nanosized particles that are associated with various physiological and pathological functions. They play a key role in intercell communication and are used as transport vehicles for various cell components.…
View article: Single-Mode Ring Resonator-Based Optomechanical Transducers for Advanced Atomic Force Sensing
Single-Mode Ring Resonator-Based Optomechanical Transducers for Advanced Atomic Force Sensing Open
Atomic force microscopy (AFM) is a widely used technique for high-resolution imaging and force sensing, yet its performance is fundamentally constrained by the cantilever size, spring constants, and mechanical frequencies. To overcome thes…
View article: Heterodyne Spectroradiometer for Precise Measurements of Carbon Dioxide
Heterodyne Spectroradiometer for Precise Measurements of Carbon Dioxide Open
Recent developments around instrumental control of carbon balance are aimed at accurate evaluation of sources and sinks of major greenhouse gases (GHG) by natural landscapes, cities, industrial and agricultural objects. And we see a s…
View article: An analytical model of label-free nanoscale chemical imaging reveals avenues toward improved spatial resolution and sensitivity
An analytical model of label-free nanoscale chemical imaging reveals avenues toward improved spatial resolution and sensitivity Open
Atomic force microscopy–infrared spectroscopy (AFM-IR) is a photothermal scanning probe technique that combines nanoscale spatial resolution with the chemical analysis capability of mid-infrared spectroscopy. Using this hybrid technique, c…
View article: ATEX-Certified, FPGA-Based Three-Channel Quantum Cascade Laser Sensor for Sulfur Species Detection in Petrochemical Process Streams
ATEX-Certified, FPGA-Based Three-Channel Quantum Cascade Laser Sensor for Sulfur Species Detection in Petrochemical Process Streams Open
In this work, a highly sensitive, selective, and industrially compatible gas sensor prototype is presented. The sensor utilizes three distributed-feedback quantum cascade lasers (DFB-QCLs), employing wavelength modulation spectroscopy (WMS…
View article: Chemical characterization of extracellular vesicles at the sub-vesicle level
Chemical characterization of extracellular vesicles at the sub-vesicle level Open
Extracellular vesicles (EVs) are nanosized particles, which are associated with various physiological and pathological functions. They play a key role in inter-cell communication and are used as transport vehicles for various cell componen…
View article: Novel insights into nanoscale surface displacement detection in polystyrene thin films using photothermal mirror- and atomic force microscopy-mid-IR spectroscopy
Novel insights into nanoscale surface displacement detection in polystyrene thin films using photothermal mirror- and atomic force microscopy-mid-IR spectroscopy Open
Introduction of photothermal mirror spectroscopy employing a highly tunable mid-IR pump laser (PTM-IR) for the chemical analysis of polystyrene thin film samples on IR transparent calcium fluoride substrates.
View article: Absorption and Dispersion: In Search of a Versatile Spectroscopic Technique
Absorption and Dispersion: In Search of a Versatile Spectroscopic Technique Open
This paper investigates three spectroscopic techniques - Tunable Diode Laser Absorption Spectroscopy (TDLAS), Wavelength Modulation Spectroscopy (WMS), and Heterodyne Phase Sensitive Dispersion Spectroscopy (HPSDS) - to evaluate their perf…
View article: Integrated Optics Waveguides and Mesoporous Oxides for the Monitoring of Volatile Organic Compound Traces in the Mid-Infrared
Integrated Optics Waveguides and Mesoporous Oxides for the Monitoring of Volatile Organic Compound Traces in the Mid-Infrared Open
Volatile organic compounds (VOCs) are an ever-growing hazard for health and environment due to their increased emissions and accumulation in the air. Quantum cascade laser-based infrared (QCL-IR) sensors hold significant promise for gas mo…
View article: All-mirror wavefront division interferometer for Fourier transform spectrometry across multiple spectral ranges
All-mirror wavefront division interferometer for Fourier transform spectrometry across multiple spectral ranges Open
We report on the design of an all-mirror wavefront-division interferometer capable of spectroscopic studies across multiple spectral ranges—from the plasma frequencies of metals to terahertz wavelengths and beyond. The proposed method leve…
View article: External Cavity Quantum Cascade Laser Vibrational Circular Dichroism Spectroscopy for Fast and Sensitive Analysis of Proteins at Low Concentrations
External Cavity Quantum Cascade Laser Vibrational Circular Dichroism Spectroscopy for Fast and Sensitive Analysis of Proteins at Low Concentrations Open
Proteins are characterized by their complex levels of structures, which in turn define their function. Understanding and evaluating these structures is therefore crucial to illuminating biological processes. One of the possible analytical …
View article: Compact vertical emitting ring interband cascade lasers for isotope-resolved CO2 sensing
Compact vertical emitting ring interband cascade lasers for isotope-resolved CO2 sensing Open
We present a compact vertically emitting ring interband cascade laser (ICL) with low power consumption and the possibility for seamless integration into various CO2 sensing applications. Our devices exhibit desirable performance characteri…