Bernhard Pfeifer
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View article: Telemedicine-supported medication titration in heart failure: evaluation of HerzMobil Tirol, Austria
Telemedicine-supported medication titration in heart failure: evaluation of HerzMobil Tirol, Austria Open
Background Heart failure is a leading cause of morbidity and mortality across Europe. Although guideline-directed medical therapy (GDMT) improves outcomes, its real-world implementation - especially dose titration to recommended target lev…
View article: Assisted therapy optimizing module to improve physician adhErence with guideLine-directed medical heart failure therapy rationale and design of the AMPEL trial
Assisted therapy optimizing module to improve physician adhErence with guideLine-directed medical heart failure therapy rationale and design of the AMPEL trial Open
View article: Effects of family history and sex on diabetes-related outcome in type 2 diabetes – Analysis from the tyrolean diabetes registry
Effects of family history and sex on diabetes-related outcome in type 2 diabetes – Analysis from the tyrolean diabetes registry Open
Aims Family history for diabetes (FHD) is a strong risk factor for type 2 diabetes (T2D), however, little is known on its effects on the outcome. Here we aimed to analyse the effects of FHD on diabetes-related outcome. Methods 7866 patient…
View article: Evolution of the COVID-19 Pandemic and Its Impact on Potential Sick Leave in the Federal State of Tyrol
Evolution of the COVID-19 Pandemic and Its Impact on Potential Sick Leave in the Federal State of Tyrol Open
Background: The COVID-19 pandemic strained healthcare systems, with Tyrol, Austria, as an early hotspot due to Alpine tourism. Variants like Alpha, Delta, and Omicron influenced infection and hospitalization trends. Objectives: To assess h…
View article: Telemedicine for Ketogenic Dietary Treatment in Epilepsy and Inherited Metabolic Diseases: Survey of Health Care Professionals
Telemedicine for Ketogenic Dietary Treatment in Epilepsy and Inherited Metabolic Diseases: Survey of Health Care Professionals Open
In refractory epilepsy and inherited metabolic disorders, Ketogenic Dietary Therapies (KDT) are established non-pharmacological treatments. Telemedicine might contribute to tackle various challenges related to KDT complexity and the respec…
View article: Development of a Synthetic Oncology Pathology Dataset for Large Language Model Evaluation in Medical Text Classification
Development of a Synthetic Oncology Pathology Dataset for Large Language Model Evaluation in Medical Text Classification Open
Background: Large Language Models (LLMs) offer promising applications in oncology pathology report classification, improving efficiency, accuracy, and automation. However, the use of real patient data is restricted due to legal and ethical…
View article: Climate Change, Vectors, and Public Health: Predicting Future Disease Risks in the Federal State Tyrol
Climate Change, Vectors, and Public Health: Predicting Future Disease Risks in the Federal State Tyrol Open
Population dynamics of vectors are strongly influenced by temperature and precipitation. We hypothesize that global warming and changes in precipitation patterns may lead to an increase in vector abundance and subsequent to a higher risk o…
View article: Enhancing Malignancy Detection and Tumor Classification in Pathology Reports: A Comparative Evaluation of Large Language Models
Enhancing Malignancy Detection and Tumor Classification in Pathology Reports: A Comparative Evaluation of Large Language Models Open
Background: Cancer registries require accurate and efficient documentation of malignancies, yet current manual methods are time-consuming and error-prone. Objectives: This study evaluates the effectiveness of large language models (LLMs) i…
View article: Validation Against Polysomnography of a Transthoracic Impedance Sensor for Screening of Sleep Apnea in Heart Failure Patients: A Pooled Analysis of AIRLESS and UPGRADE
Validation Against Polysomnography of a Transthoracic Impedance Sensor for Screening of Sleep Apnea in Heart Failure Patients: A Pooled Analysis of AIRLESS and UPGRADE Open
Background/Introduction: Cardiac implantable electronic devices and their integrated thoracic impedance sensors have been used to detect sleep apnea for over a decade now. Despite their usage in daily clinical practice, there are only limi…
View article: Telemedicine-assisted exercise program (TAEP) for coronary heart disease
Telemedicine-assisted exercise program (TAEP) for coronary heart disease Open
Introduction & Purpose Cardiovascular diseases (CVD) are a common cause of declining physical performance and quality of life. Despite the recommendation of physical activity as class 1A in the American Heart Association’s guidelines for c…
View article: Visualizing Nursing Narratives: An Evaluation of Latent Dirichlet Allocation Topic Modeling for Care Reports
Visualizing Nursing Narratives: An Evaluation of Latent Dirichlet Allocation Topic Modeling for Care Reports Open
The increasing volume of unstructured textual data in healthcare, particularly in nursing care reports, presents both challenges and opportunities for enhancing patient care and operational efficiency. This study explores the application o…
View article: Smart FOX – Enabling Citizen-Based Donation of EHR-Standardised Data for Clinical Research in Austria
Smart FOX – Enabling Citizen-Based Donation of EHR-Standardised Data for Clinical Research in Austria Open
Access to healthcare data for secondary use in clinical research is often restricted due to privacy concerns or business interests, hindering comprehensive analysis across patient pathways. The Smart FOX project seeks to address this chall…
View article: Anti‐Spike IgG antibodies as correlates of protection against SARS‐CoV‐2 infection in the pre‐Omicron and Omicron era
Anti‐Spike IgG antibodies as correlates of protection against SARS‐CoV‐2 infection in the pre‐Omicron and Omicron era Open
Anti‐Spike IgG antibodies against SARS‐CoV‐2, which are elicited by vaccination and infection, are correlates of protection against infection with pre‐Omicron variants. Whether this association can be generalized to infections with Omicron…
View article: Advancing Clinical Information Systems: Harnessing Telemedicine, Data Science, and AI for Enhanced and More Precise Healthcare Delivery
Advancing Clinical Information Systems: Harnessing Telemedicine, Data Science, and AI for Enhanced and More Precise Healthcare Delivery Open
Summary Objective: In this synopsis, the editors of the Clinical Information Systems (CIS) section of the IMIA Yearbook of Medical Informatics overview recent research and propose a selection of best papers published in 2023 in the CIS fie…
View article: A Neuronal Network-Based Score Predicting Survival in Patients Undergoing Aortic Valve Intervention: The ABC-AS Score
A Neuronal Network-Based Score Predicting Survival in Patients Undergoing Aortic Valve Intervention: The ABC-AS Score Open
Background: Despite being the most commonly performed valvular intervention, risk prediction for aortic valve replacement in patients with severe aortic stenosis by currently used risk scores remains challenging. The study aim was to devel…
View article: Telemedicine for Ketogenic Dietary Treatment in Refractory Epilepsy and Inherited Metabolic Disease: State of Play and Future Perspectives
Telemedicine for Ketogenic Dietary Treatment in Refractory Epilepsy and Inherited Metabolic Disease: State of Play and Future Perspectives Open
Ketogenic dietary therapies (KDT) are diets that induce a metabolic condition comparable to fasting. All types of KDT comprise a reduction in carbohydrates whilst dietary fat is increased up to 90% of daily energy expenditure. The amount o…
View article: Unveiling the Surge: A Comprehensive Analysis of the Stimulating Impact of the Covid-19 Pandemic on Telemedicine and Its Academic Landscape
Unveiling the Surge: A Comprehensive Analysis of the Stimulating Impact of the Covid-19 Pandemic on Telemedicine and Its Academic Landscape Open
The Covid-19 pandemic spurred an unprecedented shift towards digitalization, prompting a surge in telehealth practices. This paper explores the impact of the pandemic on telemedicine through a comprehensive analysis of scientific publicati…
View article: Health data space nodes for privacy-preserving linkage of medical data to support collaborative secondary analyses
Health data space nodes for privacy-preserving linkage of medical data to support collaborative secondary analyses Open
Introduction The potential for secondary use of health data to improve healthcare is currently not fully exploited. Health data is largely kept in isolated data silos and key infrastructure to aggregate these silos into standardized bodies…
View article: Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023
Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023 Open
Background: To provide updated estimates on SARS-CoV-2 antibody seroprevalence and average antibody titres for Central Europe. Methods: In repeat cross-sectional investigations (1 May 2022 to 9 March 2023) involving 28,768 blood donors in …
View article: Cost-effectiveness of a multidimensional post-discharge disease management program for heart failure patients—economic evaluation along a one-year observation period
Cost-effectiveness of a multidimensional post-discharge disease management program for heart failure patients—economic evaluation along a one-year observation period Open
View article: Penetrance, cancer incidence and survival in <i>HFE</i> haemochromatosis—A population‐based cohort study
Penetrance, cancer incidence and survival in <i>HFE</i> haemochromatosis—A population‐based cohort study Open
Background and Aims Haemochromatosis is characterized by progressive iron overload affecting the liver and can cause cirrhosis and hepatocellular carcinoma. Most haemochromatosis patients are homozygous for p.C282Y in HFE , but only a mino…
View article: HerzMobil Tirol – A telemedical, integrated disease management program for patients with heart failure
HerzMobil Tirol – A telemedical, integrated disease management program for patients with heart failure Open
Heart failure (HF) is a global health problem with an increasing an increasing incidence and prevalence and thus a major impact on healthcare systems. The 1-year mortality is 23.6% in patients with acute HF. Hospitalization for acute HF is…
View article: Collaborative goal setting for patients with heart failure based on the ICF to support integrated care
Collaborative goal setting for patients with heart failure based on the ICF to support integrated care Open
Heart failure (HF), a noncommunicable disease (NCD), is one of the main reasons for hospitalization of older patient groups. The prevalence in adults is estimated to be 1-2% and is described to be increasing in the older population (11,8%)…
View article: The Tyrolean Federal Institute for Integrated Care (LIV Tyrol)
The Tyrolean Federal Institute for Integrated Care (LIV Tyrol) Open
A constantly increasing life expectancy of society leads to an increase in severe chronic diseases, which are accompanied by negative effects on the quality of life for patients and an increasing number of hospital admissions as well as lo…
View article: A Pathway to Prevention – Concept of the Tyrolean Approach
A Pathway to Prevention – Concept of the Tyrolean Approach Open
Health is an ongoing, natural process rather than a temporary state. To preserve and promote health, a structured, personalized, holistic, and coherent approach for primary and secondary prevention is needed. A study by Widschwendter et al…
View article: Impact of route of access and stenosis subtype on outcome after transcatheter aortic valve replacement
Impact of route of access and stenosis subtype on outcome after transcatheter aortic valve replacement Open
Introduction Previous analyses have reported the outcomes of transcatheter aortic valve replacement (TAVR) for patients with low-flow, low-gradient (LFLG) aortic stenosis (AS), without stratifying according to the route of access. Differen…
View article: Cost-effectiveness of HerzMobil Tirol, a multidimensional post-discharge disease management program for heart failure patients Economic evaluation along a one-year observation period
Cost-effectiveness of HerzMobil Tirol, a multidimensional post-discharge disease management program for heart failure patients Economic evaluation along a one-year observation period Open
Methods We conducted a cost-effectiveness analysis along a retrospective cohort study of the routine DMP in the province of Tyrol, Austria (HerzMobil Tirol, DMP-HMT) with a propensity score matched cohort of 257 individuals in the usual ca…
View article: Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae Open
Purpose Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, phys…
View article: Transforming Clinical Information Systems: Empowering Healthcare through Telemedicine, Data Science, and Artificial Intelligence Applications
Transforming Clinical Information Systems: Empowering Healthcare through Telemedicine, Data Science, and Artificial Intelligence Applications Open
Objective: In this synopsis, the editors of the Clinical Information Systems (CIS) section of the IMIA Yearbook of Medical Informatics overview recent research and propose a selection of best papers published in 2022 in the CIS field. Meth…
View article: Visualization of the SyncAV® Algorithm for CRT Optimization by Non-invasive Imaging of Cardiac Electrophysiology: NICE-CRT Trial
Visualization of the SyncAV® Algorithm for CRT Optimization by Non-invasive Imaging of Cardiac Electrophysiology: NICE-CRT Trial Open
(1) Background: Periodic repetitive AV interval optimization using a device-based algorithm in cardiac resynchronization therapy (CRT) devices may improve clinical outcomes. There is an unmet need to successfully transform its application …