Michael Poidinger
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Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection Open
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Additional file 2 of Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination Open
Additional file 2: Table S1. Summary of data sources.
Additional file 3 of Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination Open
Additional file 3: Table S2. Details of the Mann-Whitney test statistics on the impact of epigenetic marks on the NCO recombination rate in genomic subregions (Fig. 3A). A description of all the columns in the table is provided in the work…
Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination Open
The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable. We evaluated the immune and metabolic profiles of 205 elderly Singaporeans administ…
Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence Open
The current TB treatment regimen involves a combination of drugs administered for an extended duration that could last for 6 months to 2 years. This could lead to noncompliance and the emergence of newer drug resistance strains.
Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality Open
Objective Gastric cancer (GC) tumors are highly heterogenous with different subpopulations of epithelial cells. We employed single cell RNA sequencing (scRNA-seq) to dissect the heterogeneity and identified subpopulations of cancer cells w…
View article: Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells
Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells Open
Key Points Transcriptional profile of LCH CD1a+CD207+ DCs is most closely related to that of CD1c+ mDCs in the blood. Lineage tracing with BRAFV600E and HLA-DQB2 expression supports CD1c+ mDCs as precursors to LCH CD1a+CD207+ DCs.
Host cholesterol dependent activation of VapC12 toxin enriches persister population during <i>Mycobacterium tuberculosis</i> infection Open
A worldwide increase in the frequency of multidrug-resistant and extensively drug-resistant cases of tuberculosis is mainly due to therapeutic noncompliance associated with a lengthy treatment regimen. Depending on the drug susceptibility …
Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation Open
Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the expression levels are strongly influenced by genetic polymorphisms. Mechanisms and functional implications of this ge…
Histone acetylome-wide association study of tuberculosis Open
Host-cell chromatin changes are thought to play an important role in the pathogenesis of infectious diseases. Here, we describe the first histone acetylome-wide association study (HAWAS) of an infectious disease, based on genome-wide H3K27…
RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types Open
The molecular characterization of immune subsets is important for designing effective strategies to understand and treat diseases. We characterized 29 immune cell types within the peripheral blood mononuclear cell (PBMC) fraction of health…
Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells Open
Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (…
Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure Open
Background: Elderly adults over 65 years of age are recommended to receive seasonal influenza vaccination as they are at a higher risk of infection and its complications than the younger community. The elderly are often stratified accordin…
Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation Open
Image cytometry is the process of converting image data to flow cytometry-style plots, and it usually requires computer-aided surface creation to extract out statistics for cells or structures. One way of dealing with structures stained wi…
Publisher Correction: IgG1 memory B cells keep the memory of IgE responses Open
The originally published version of this Article contained errors in Fig. 4 that were introduced during the production process. In panel c, the two uppermost labels ‘IgE spleen’ and ‘IgE BM’ incorrectly read ‘IgG1 spleen’ and ‘IgE1 BM’, re…
Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway Open
Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a co…