Bernhard Radlinger
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View article: TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence Open
Entry into and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering…
View article: Non-Traumatic Lower-Limb Amputations: Outcome, Sex-Differences, Comorbidity Patterns and Temporal Trends from 2006 to 2022
Non-Traumatic Lower-Limb Amputations: Outcome, Sex-Differences, Comorbidity Patterns and Temporal Trends from 2006 to 2022 Open
Background/Objectives: Non-traumatic lower-limb amputations are associated with high mortality and a dramatic loss of quality of life. Peripheral artery disease and diabetes are the most common causes of non-traumatic lower-limb amputation…
View article: TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence
TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence Open
Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here, we demonstrate that cells enter…
View article: Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis Open
Aims/hypothesis Sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used in the treatment of type 2 diabetes, heart failure and chronic kidney disease. Their role in the prevention of diet-induced metabolic deteriorations, such as…
View article: 100 years of inherited metabolic disorders in Austria—A national registry of minimal birth prevalence, diagnosis, and clinical outcome of inborn errors of metabolism in Austria between 1921 and 2021
100 years of inherited metabolic disorders in Austria—A national registry of minimal birth prevalence, diagnosis, and clinical outcome of inborn errors of metabolism in Austria between 1921 and 2021 Open
Inherited metabolic disorders (IMDs) are a heterogeneous group of rare disorders characterized by disruption of metabolic pathways. To date, data on incidence and prevalence of IMDs are limited. Taking advantage of a functioning network wi…
View article: Changing the dietary composition improves inflammation but not adipocyte thermogenesis in diet-induced obese mice
Changing the dietary composition improves inflammation but not adipocyte thermogenesis in diet-induced obese mice Open
Pronounced weight loss was shown to improve adipocyte dysfunction and insulin sensitivity in obese subjects. While bariatric surgery is frequently accompanied by adverse side effects, weight loss due to caloric restriction is often followe…
View article: Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice
Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice Open
ApoA5 is involved in fructose-induced metabolic dysregulation and associated hepatic steatosis suggesting that apoA5 may be a novel target to treat metabolic diseases.
View article: Cardioprotective effects of short-term empagliflozin treatment in db/db mice
Cardioprotective effects of short-term empagliflozin treatment in db/db mice Open
Sodium glucose transporter (SGLT)-2 inhibitors have consistently shown cardioprotective effects independent of the glycemic status of treated patients. In this study we aimed to investigate underlying mechanisms of short-term empagliflozin…
View article: Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes Open