Bernhard H. Rauch
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View article: Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech Hirudinaria manillensis
Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech Hirudinaria manillensis Open
Hematophagous leeches rely on a broad diversity of bioactive factors that interfere with the host’s defense systems to secure a successful blood meal. The most prominent examples of such factors are the antithrombotics that address either …
View article: Hirudins and fenestrins of the African medicinal leech Asiaticobdella fenestrata
Hirudins and fenestrins of the African medicinal leech Asiaticobdella fenestrata Open
African hematophagous leeches are largely underinvestigated both in terms of their biodiversity and the characterization of the broad repertoire of bioactive components of their salivary gland secretions. Asiaticobdella (formerly Aliolimna…
View article: Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment
Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment Open
Patients with overt cerebral ischemia are at risk for adverse events after hospital discharge. Sphingosine-1-phosphate is a potent lipid mediator produced and secreted by platelets, which is inhibited via acetylsalicylic acid (ASA). The as…
View article: Water-Soluble, Titanocene-Based Prodrugs with Thiosemicarbazones as Cytotoxic Agents
Water-Soluble, Titanocene-Based Prodrugs with Thiosemicarbazones as Cytotoxic Agents Open
Prodrugs that improve drug delivery in the body are highly desirable because they increase drug solubility and activity, thereby reducing drug concentration and side effects compared to the actual active compound. In this work, we demonstr…
View article: The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells
The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells Open
Background Glioblastoma (GBM) remains the most aggressive and common malignant brain tumor in adults, often accompanied by venous thromboembolism due to hypercoagulability. Protease-activated receptors (PAR1-4) are thought to influence GBM…
View article: Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo
Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo Open
Colon cancer is among the most common cancer types worldwide. Signaling pathways that control cell proliferation and migration play a crucial role in its progression. The G-protein-coupled protease-activated receptors (PARs) are associated…
View article: Sex specific association of body composition with sphingosine-1-phosphate levels-results from the study of health in pomerania (SHIP) analysis
Sex specific association of body composition with sphingosine-1-phosphate levels-results from the study of health in pomerania (SHIP) analysis Open
Background/Introduction Sphingosine-1-Phosphate (S1P), is a highly bioactive lipid mediator that+ plays an important role in many physiological and pathophysiological processes and is associated with various cardiovascular and metabolic di…
View article: Age influences the association between sphingosin-1-phosphate and arginine derivatives in the general population
Age influences the association between sphingosin-1-phosphate and arginine derivatives in the general population Open
Introduction Sphingosine-1-phosphate (S1P) and derivatives of arginine (i.e. symmetric [SDMA] and asymmetric [ADMA] dimethylarginine), have been linked to endothelial dysfunction and cardiovascular diseases. However, the relationship betwe…
View article: Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta
Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta Open
Haematophagous leeches rely on a broad variety of bioactive compounds to secure a sufficient blood meal from their vertebrate prey. Both the primary (platelet aggregation) and secondary (blood coagulation) haemostasis are the main targets …
View article: Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents
Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents Open
Viral infections can lead to platelet activation and hemostatic complications. However, the extent to which platelet reactivity remains altered after convalescence, contributing to long-term health impairments as observed after COVID-19 is…
View article: Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta
Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta Open
Haematophagous leeches rely on a broad variety of bioactive compounds to secure a sufficient blood meal from their vertebrate prey. Both the primary (platelet aggregation) and secondary (blood coagulation) haemostasis are main targets of a…
View article: Pro-inflammatory sensitization of platelets after a mild course of COVID-19 infection
Pro-inflammatory sensitization of platelets after a mild course of COVID-19 infection Open
Background Coronavirus disease-2019 (COVID-19) is a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) which can lead to an increased risk of thromboembolic events but also complicatio…
View article: Effects of the activated coagulation factor X (FXa) and its protease-activated receptor-2 (PAR2) on colon cancer cell growth in vitro and in vivo
Effects of the activated coagulation factor X (FXa) and its protease-activated receptor-2 (PAR2) on colon cancer cell growth in vitro and in vivo Open
Background Protease-activated receptors are a family of four (PAR1-4) G-protein-coupled receptors with a unique mechanism of activation. Serine proteases such as the activated coagulation factor X (FXa) can activate PARs, selectively PAR2,…
View article: The Putative S1PR1 Modulator ACT-209905 Impairs Growth and Migration of Glioblastoma Cells In Vitro
The Putative S1PR1 Modulator ACT-209905 Impairs Growth and Migration of Glioblastoma Cells In Vitro Open
Glioblastoma (GBM) is still a deadly tumor due to its highly infiltrative growth behavior and its resistance to therapy. Evidence is accumulating that sphingosine-1-phosphate (S1P) acts as an important tumor-promoting molecule that is invo…
View article: Sphingosine-1-phosphate levels are inversely associated with left ventricular and atrial chamber volume and cardiac mass in men
Sphingosine-1-phosphate levels are inversely associated with left ventricular and atrial chamber volume and cardiac mass in men Open
Aims Sphingosine-1-phosphate (S1P) is a signaling lipid, which is involved in several cellular processes including cell growth, proliferation, migration and apoptosis. The associations of serum S1P levels with cardiac geometry and function…
View article: Data from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Data from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Purpose:Apoptotic dysregulation, redox adaptive mechanisms, and resilience to hypoxia are major causes of glioblastoma (GBM) resistance to therapy. Commonly known as crucial factors in energy metabolism, OCTN2 (SLC22A5) and its substrate L…
View article: Supplementary Figure S1 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Figure S1 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Survival analysis of patients with primary GBM dependent on therapy and resection status
View article: Data from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Data from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Purpose:Apoptotic dysregulation, redox adaptive mechanisms, and resilience to hypoxia are major causes of glioblastoma (GBM) resistance to therapy. Commonly known as crucial factors in energy metabolism, OCTN2 (SLC22A5) and its substrate L…
View article: Supplementary Figure S2 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Figure S2 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Expression and survival analyses of CPT1A and CPT1C in GBM specimens
View article: Supplementary Text from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Text from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Additional information on the immunoblot analysis, cell line characteristics and our glioma mouse model
View article: Supplementary Text from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Text from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Additional information on the immunoblot analysis, cell line characteristics and our glioma mouse model
View article: Supplementary Figure S2 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Figure S2 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Expression and survival analyses of CPT1A and CPT1C in GBM specimens
View article: Supplementary Figure S1 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Supplementary Figure S1 from <i>L</i>-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme Open
Survival analysis of patients with primary GBM dependent on therapy and resection status
View article: tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions
tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions Open
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas f…
View article: Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients
Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients Open
Glioblastoma is the most common and lethal primary brain malignancy that almost inevitably recurs as therapy-refractory cancer. While the success of immune checkpoint blockade (ICB) revealed the immense potential of immune-targeted therapi…
View article: Go West: Hirudins and Decorsin/Ornatin-like Platelet Aggregation Inhibitors in Two Representatives of American Hematophagous Leeches
Go West: Hirudins and Decorsin/Ornatin-like Platelet Aggregation Inhibitors in Two Representatives of American Hematophagous Leeches Open
Hematophagous leeches express a broad variety of secretory factors in their salivary glands; among them are hirudins, inhibitors of blood coagulation, and decorsins/ornatins, inhibitors of platelet aggregation. Here, we describe the identi…
View article: Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases
Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases Open
Sphingosine-1-phosphate (S1P) is a versatile signaling lipid involved in the regulation of numerous cellular processes. S1P regulates cellular proliferation, migration, and apoptosis as well as the function of immune cells. S1P is generate…
View article: Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection
Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection Open
We analyzed symptoms and comorbidities as predictors of hospitalization in 710 outpatients in North-East Germany with PCR-confirmed SARS-CoV-2 infection. During the first 3 days of infection, commonly reported symptoms were fatigue (71.8%)…