Bernhard Stoffelns
YOU?
Author Swipe
View article: Systemic Inflammation in Retinal Vein Occlusion and Its Role in Clinical Outcomes of Secondary Macular Edema
Systemic Inflammation in Retinal Vein Occlusion and Its Role in Clinical Outcomes of Secondary Macular Edema Open
Objectives: This study aims to analyze the association between systemic inflammation and clinical outcomes in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: A retrospective analysis of 68 patients with acut…
View article: Visual acuity, amblyopia and refractive error in preterm children with and without retinopathy of prematurity – Results from the Gutenberg Prematurity Study Young (GPSY)
Visual acuity, amblyopia and refractive error in preterm children with and without retinopathy of prematurity – Results from the Gutenberg Prematurity Study Young (GPSY) Open
Purpose This study aims to assess visual outcomes in children born preterm, stratified by gestational age, hypo‐ and hypertrophy, and the presence of retinopathy of prematurity (ROP) and its treatment. Methods This is a prospective observa…
View article: Safety and Long-Term Efficacy of Intravitreal rtPA, Bevacizumab and SF6 Injection in Patients with Submacular Hemorrhage Secondary to Age-Related Macular Degeneration
Safety and Long-Term Efficacy of Intravitreal rtPA, Bevacizumab and SF6 Injection in Patients with Submacular Hemorrhage Secondary to Age-Related Macular Degeneration Open
Purpose: Acute submacular hemorrhage (SMH) is a vision-threatening complication common in patients affected by age-related macular degeneration (AMD). This study evaluates safety, long-term clinical outcomes and associated treatment factor…
View article: Clinical Outcomes Following a Switch of Therapy to Faricimab in Patients Affected by Neovascular Age-Related Macular Degeneration
Clinical Outcomes Following a Switch of Therapy to Faricimab in Patients Affected by Neovascular Age-Related Macular Degeneration Open
Objectives: In this study, we evaluated clinical outcomes following a therapy switch to Faricimab, in a patient cohort affected by neovascular age-related macular degeneration (nAMD), having received prior intravitreal anti-VEGF therapy. M…
View article: Associations of preterm birth and neonatal stress exposure with chronic pain in adulthood – Results from the Gutenberg prematurity study
Associations of preterm birth and neonatal stress exposure with chronic pain in adulthood – Results from the Gutenberg prematurity study Open
Although the effect of early childhood stress on central nervous pain processing is well known, studies on the association of prematurity and chronic pain are scarce. This study used data from a single-centre retrospective cohort study fol…
View article: Short-Term Clinical Outcomes of Patients with Diabetic Macular Edema Following a Therapy Switch to Faricimab
Short-Term Clinical Outcomes of Patients with Diabetic Macular Edema Following a Therapy Switch to Faricimab Open
Background: With this study, we investigate the short-term clinical outcomes of patients affected by diabetic macular edema (DME) after switching to intravitreal Faricimab (IVF) in a real-world setting. Methods: We conducted a retrospectiv…
View article: Sex-Specific Differences in the Relationship Between Prematurity and Ocular Geometry
Sex-Specific Differences in the Relationship Between Prematurity and Ocular Geometry Open
This study identified a sex-specific correlation between lower GA and thicker central foveal thickness, suggesting differences in the developmental trajectory of this biometric parameter concerning GA. A thicker central foveal thickness mi…
View article: Macular Curvature in Adults Born Preterm With and Without ROP: Results from the Gutenberg Prematurity Eye Study
Macular Curvature in Adults Born Preterm With and Without ROP: Results from the Gutenberg Prematurity Eye Study Open
Adults treated for ROP had relatively more negative curvature values compared to the full-term group, indicating a macular protrusion toward the vitreous cave. A thicker subfoveal choroidal thickness was associated with a flatter macular c…
View article: Prevalence of strabismus and risk factors in adults born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye study
Prevalence of strabismus and risk factors in adults born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye study Open
Aim The purpose of this study was to assess the prevalence of strabismus and nystagmus and to analyse associated factors in preterm and full-term infants in adulthood. Methods The Gutenberg Prematurity Eye Study is a retrospective cohort s…
View article: Fetal Growth Restriction Leads to an Enlarged Cup-to-Disc Ratio in Adults Born at Full Term
Fetal Growth Restriction Leads to an Enlarged Cup-to-Disc Ratio in Adults Born at Full Term Open
This study provides evidence that individuals born at-term with severe SGA have an increased VCDR, suggesting that fetal growth restriction has a lasting impact on optic disc morphology independent of prematurity throughout adulthood.
View article: Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System
Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System Open
Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central retina, which holds global significance as the fourth leading cause of blindness. The condition is characterized by a multifaceted pathophysiology t…
View article: Impact of preterm birth on the onset of panic disorder in later life – Results from the Gutenberg Prematurity Study (GPS)
Impact of preterm birth on the onset of panic disorder in later life – Results from the Gutenberg Prematurity Study (GPS) Open
Prematurity likely increases the risk of panic disorder later in life, and the subsequent postnatal ICU-stay appears to be of critical importance. However, due to strong collinearity and other associated factors with preterm births, it rem…
View article: Ocular geometry in adults born small, appropriate or large for gestational age at term
Ocular geometry in adults born small, appropriate or large for gestational age at term Open
Purpose Intrauterine growth restriction leading to a birth weight (BW) which is too low for gestational age (GA) is a known risk factor for various altered organ morphologies and dysfunction in later life. This study aimed to determine for…
View article: β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding Open
β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors (GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine. Three subtypes of β-ARs (β1, β2, and β3) have been identified with …
View article: Corneal Aberrations and Thickness in Adults Born Small, Appropriate, or Large for Gestational Age at Term
Corneal Aberrations and Thickness in Adults Born Small, Appropriate, or Large for Gestational Age at Term Open
Background/Aims: This study investigated whether there are changes in corneal surface regularity and corneal thickness in adults born small, appropriate, or large for gestational age at term. Methods: This retrospective cohort study involv…
View article: The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood: Results from the Gutenberg prematurity eye study
The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood: Results from the Gutenberg prematurity eye study Open
Introduction Prematurity and retinopathy of prematurity (ROP) are associated with altered corneal shape and reduced visual acuity in childhood, but their long‐term effects on corneal shape in later life are still unclear. This study evalua…
View article: Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study
Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study Open
Altered choroidal layer development caused by perinatal influence factors might be a risk factor for reduced visual function and predispose affected individuals to eye diseases in later life.
View article: Dry Eye Parameters and Lid Geometry in Adults Born Extremely, Very, and Moderately Preterm with and without ROP: Results from the Gutenberg Prematurity Eye Study
Dry Eye Parameters and Lid Geometry in Adults Born Extremely, Very, and Moderately Preterm with and without ROP: Results from the Gutenberg Prematurity Eye Study Open
Background/Aims: This study aimed to analyze the effects of perinatal history on tear film properties and lid geometry in adults born preterm. Methods: The Gutenberg Prematurity Eye Study (GPES) is a German prospective examination of adult…
View article: Refractive error, accommodation and lens opacification in adults born preterm and full‐term: Results from the Gutenberg Prematurity Eye Study (<scp>GPES</scp>)
Refractive error, accommodation and lens opacification in adults born preterm and full‐term: Results from the Gutenberg Prematurity Eye Study (<span>GPES</span>) Open
Purpose To evaluate the long‐term effects of different degrees of prematurity, retinopathy of prematurity (ROP) and associated perinatal factors on refractive error, accommodation and lens opacification development in adults born preterm a…
View article: Anterior Chamber Angle in Adults Born Extremely, Very, and Moderately Preterm with and without Retinopathy of Prematurity—Results of the Gutenberg Prematurity Eye Study
Anterior Chamber Angle in Adults Born Extremely, Very, and Moderately Preterm with and without Retinopathy of Prematurity—Results of the Gutenberg Prematurity Eye Study Open
Purpose: To determine whether prematurity and associated factors affect the anterior chamber angle (ACA) width in adulthood. Methods: The Gutenberg Prematurity Eye Study (GPES) is a retrospective cohort study with a prospective ophthalmolo…
View article: Association of Birth Weight With Foveolar Thickness in Adulthood: Results From a Population-Based Study
Association of Birth Weight With Foveolar Thickness in Adulthood: Results From a Population-Based Study Open
This study provides evidence of an association between lower BW and increased foveolar thickness and foveal hypoplasia, indicating that prenatal growth may affect macular morphology, which in turn may persist until adulthood and predispose…
View article: Supplementary Material for: Incidence of Retinal Detachment in Germany: Results from the Gutenberg Health Study
Supplementary Material for: Incidence of Retinal Detachment in Germany: Results from the Gutenberg Health Study Open
Purpose: To investigate the incidence of retinal detachment in the German population and to assess potential risk factors. Methods: The Gutenberg Health Study is a population-based cohort study in Mainz, Germany, including subjects (n = 15…
View article: Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study
Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study Open
Purpose We aimed to determine the prevalence of characteristics and pathologies of the vitreo‐macular interface within the general population. Methods The Gutenberg Health Study is a population‐based study in Germany, including an ophthalm…