Bernice A. Monchusi
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View article: Cancer-derived exosomes: mediators of immune crosstalk and emerging targets for immunotherapy
Cancer-derived exosomes: mediators of immune crosstalk and emerging targets for immunotherapy Open
Exosomes, nanoscale extracellular vesicles secreted by various cell types, play pivotal roles in intercellular communication. In cancer, tumor-derived exosomes—referred to as cancer-derived exosomes (CDEs)—have emerged as critical regulato…
View article: The first-in-Africa ex vivo drug sensitivity testing platform identifies novel drug combinations for South African leukaemia patient cohort
The first-in-Africa ex vivo drug sensitivity testing platform identifies novel drug combinations for South African leukaemia patient cohort Open
View article: Phytochemical screening, characterization, and in vitro anti-metastatic effects of the methanolic leaf extract of <i>Momordica cardiospermoides</i> in MDA-MB 321 cells
Phytochemical screening, characterization, and in vitro anti-metastatic effects of the methanolic leaf extract of <i>Momordica cardiospermoides</i> in MDA-MB 321 cells Open
Introduction: Momordica cardiospermoides represents an inexhaustible source of natural products. We examined the acetone and methanolic extracts of M. cardiospermoides leaves’ phytochemical composition, antioxidant activities, and anti-met…
View article: Synthesis, structural characterization, and quantum chemical study of the 7-acetyl-5-nitrobenzofurans as anticancer agents with antioxidant properties
Synthesis, structural characterization, and quantum chemical study of the 7-acetyl-5-nitrobenzofurans as anticancer agents with antioxidant properties Open
Synthesis of 7-acetyl-2-aryl-5-nitrobenzofurans 2a–j involved sequential Sonogashira cross-coupling of 2-hydroxy-3-iodo-5-nitroacetophenone with terminal acetylenes and in situ Cacchi-type cycloisomerization of 5-alkynylated intermediates.…
View article: CCDC 2164730: Experimental Crystal Structure Determination
CCDC 2164730: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2154588: Experimental Crystal Structure Determination
CCDC 2154588: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2164727: Experimental Crystal Structure Determination
CCDC 2164727: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2164729: Experimental Crystal Structure Determination
CCDC 2164729: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2164720: Experimental Crystal Structure Determination
CCDC 2164720: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: microRNAs targeting cellular cholesterol: implications for combating anticancer drug resistance
microRNAs targeting cellular cholesterol: implications for combating anticancer drug resistance Open
Over sixty percent of all mammalian protein-coding genes are estimated to be regulated by microRNAs (miRNAs), and unsurprisingly miRNA dysregulation has been linked with cancer. Aberrant miRNA expression in cancer cells has been linked wit…
View article: Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy
Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy Open
The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in cancer cells. We h…