Bert Müller
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View article: Determining the thickness of convoluted cell layers in microtomography
Determining the thickness of convoluted cell layers in microtomography Open
Microtomography enables the three-dimensional imaging of cellular details of the entire mouse choroid plexus (ChP). This anatomical structure is vital for regulating the fluid balance in the brain. During aging, its epithelial cells flatte…
View article: Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data
Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data Open
Synchrotron radiation‐based X‐ray microtomography is uniquely suited for post‐mortem 3D visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution requires an extended …
View article: Determining Aligner-Induced Tooth Movements in Three Dimensions Using Clinical Data of Two Patients
Determining Aligner-Induced Tooth Movements in Three Dimensions Using Clinical Data of Two Patients Open
The effectiveness of a series of optically transparent aligners for orthodontic treatments depends on the anchoring of each tooth. In contrast with the roots, the crowns’ positions and orientations are measurable with intraoral scans, thus…
View article: Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: augmenting interactive brain atlases with terabyte data
Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: augmenting interactive brain atlases with terabyte data Open
Synchrotron radiation-based X-ray microtomography is uniquely suited for post mortem three-dimensional visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution requir…
View article: Aligner-induced tooth movements in three dimensions using clinical data of two patients
Aligner-induced tooth movements in three dimensions using clinical data of two patients Open
The effectiveness of a series of optically transparent aligners for orthodontic treatments depends on the anchoring of each tooth. In contrast with roots, the crowns' positions and orientations are measurable with intraoral scans, thus avo…
View article: Reentry of endodontic access cavities: composite residue and loss of tooth substance
Reentry of endodontic access cavities: composite residue and loss of tooth substance Open
The purpose of this study was to investigate the ability of dentists to remove composite fillings from endodontic access cavities using illumination from a conventional light source (CLS) versus the fluorescence-aided identification techni…
View article: Synchrotron radiation-based micro computed tomography dataset - in vivo mouse brain - CA019 - Choroid plexus motion
Synchrotron radiation-based micro computed tomography dataset - in vivo mouse brain - CA019 - Choroid plexus motion Open
Imaging choroid plexus motion at CLS BMIT beamline This datasets features a synchrotron radiation-based micro computed tomography dataset of a C57BL/6J mouse injected with barium-based contrast agent into the lateral ventricle. Data was re…
View article: Multi-resolution X-ray phase-contrast and dark-field tomography of human cerebellum with near-field speckles
Multi-resolution X-ray phase-contrast and dark-field tomography of human cerebellum with near-field speckles Open
In this study, we use synchrotron-based multi-modal X-ray tomography to examine human cerebellar tissue in three dimensions at two levels of spatial resolution (2.3 µm and 11.9 µm). We show that speckle-based imaging (SBI) produces results…
View article: 3D X-ray Histology for the Investigation of Temporal Lobe Epilepsy in a Mouse Model
3D X-ray Histology for the Investigation of Temporal Lobe Epilepsy in a Mouse Model Open
The most common form of epilepsy among adults is mesial temporal lobe epilepsy (mTLE), with seizures often originating in the hippocampus due to abnormal electrical activity. The gold standard for the histopathological analysis of mTLE is …
View article: Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney
Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney Open
The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume, high-q…
View article: Apochromatic X-ray focusing
Apochromatic X-ray focusing Open
Achromatic doublets are combinations of two individual lenses designed to focus different wavelengths of light in the same position. Apochromatic optics are improved versions of the achromatic schemes which extend the wavelength range sign…
View article: Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of the kidney
Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of the kidney Open
Nephrotoxicity is an important drug safety aspect to be assessed during drug discovery and development. To study renal toxicity, in vitro cell-based assays are often used. Unfortunately, translating the results of such cell assays to verte…
View article: Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of renal organs
Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of renal organs Open
This repository contains reconstructed µCT scans acquired at the SOLEIL synchrotron facility which were analyzed in the above mentioned publication. The first set of scans shows mouse kidney biopsies. One representative scan from the contr…
View article: Three-dimensional imaging of porcine joints down to the subcellular level
Three-dimensional imaging of porcine joints down to the subcellular level Open
Joint tissues consist of trabecular and cortical bone as well as calcified\nand hyaline cartilage, which presents a challenge for hard X-ray-based\nvisualization on the sub-cellular level due to the wide range of local X-ray\nabsorption va…
View article: Tomographic imaging of microvasculature with a purpose-designed, polymeric x-ray contrast agent
Tomographic imaging of microvasculature with a purpose-designed, polymeric x-ray contrast agent Open
Imaging of microvasculature is primarily performed with X-ray contrast agents, owing to the wide availability of absorption-contrast laboratory source microCT compared to phase contrast capable devices. Standard commercial contrast agents …
View article: Micro-patterned cellulose films for flexible electrodes in medical implants
Micro-patterned cellulose films for flexible electrodes in medical implants Open
Neuromodulation treatments are based on the functional interface between the brain and man-made electrodes. Chronic inflammation around the implant, however, occurs as a result of mechanical mismatching between soft brain tissue and the st…
View article: Imaging data of mechanically loaded, micro-patterned, silk-reinforced cellulose films with gold coating for flexible electrodes in medical implants
Imaging data of mechanically loaded, micro-patterned, silk-reinforced cellulose films with gold coating for flexible electrodes in medical implants Open
Neurodegenerative diseases can be treated using a functional interface between the physically soft tissue such as brain and the man-made electrodes. The orders of magnitude harder neural probes cause local injuries, due to periodic micromo…
View article: Imaging data of mechanically loaded, micro-patterned, silk-reinforced cellulose films with gold coating for flexible electrodes in medical implants
Imaging data of mechanically loaded, micro-patterned, silk-reinforced cellulose films with gold coating for flexible electrodes in medical implants Open
Neurodegenerative diseases can be treated using a functional interface between the physically soft tissue such as brain and the man-made electrodes. The orders of magnitude harder neural probes cause local injuries, due to periodic micromo…
View article: Special Section Guest Editorial: Hard X-Ray Tomography with Micrometer Resolution
Special Section Guest Editorial: Hard X-Ray Tomography with Micrometer Resolution Open
JMI guest editors introduce articles collected in the JMI Special Section on Hard X-Ray Tomography with Micrometer Resolution, a snapshot of this important niche area featured by hard x-ray tomography at the micrometer level.
View article: Combining High-Resolution Hard X-ray Tomography and Histology for Stem Cell-Mediated Distraction Osteogenesis
Combining High-Resolution Hard X-ray Tomography and Histology for Stem Cell-Mediated Distraction Osteogenesis Open
Distraction osteogenesis is a clinically established technique for lengthening, molding and shaping bone by new bone formation. The experimental evaluation of this expensive and time-consuming treatment is of high impact for better underst…
View article: Three-dimensional analysis of aligner gaps and thickness distributions, using hard x-ray tomography with micrometer resolution
Three-dimensional analysis of aligner gaps and thickness distributions, using hard x-ray tomography with micrometer resolution Open
Hard x-ray tomography with micrometer resolution is a powerful technique employed to localize the gaps between aligners and teeth, and it also enables film thickness measurements after thermoforming. The thicker film on the occlusal surfac…
View article: Three-dimensional imaging and analysis of annual layers in tree trunk and tooth cementum
Three-dimensional imaging and analysis of annual layers in tree trunk and tooth cementum Open
The growth of plants, animals, and humans can give rise to layered structures\nassociated with annual periodicity. Thickness variations are often correlated\nto nutrition supply and stress factors. The annual layers in a tree trunk with\nm…
View article: Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve
Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve Open
Purpose: Synchrotron radiation-based tomography yields microanatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compared the …
View article: Virtual histology of an entire mouse brain from formalin fixation to paraffin embedding. Part 2: Volumetric strain fields and local contrast changes
Virtual histology of an entire mouse brain from formalin fixation to paraffin embedding. Part 2: Volumetric strain fields and local contrast changes Open
Our approach belongs to three-dimensional virtual histology with isotropic micrometer spatial resolution and therefore complements atlases based on a combination of magnetic resonance microscopy and optical micrographs of serial histologic…
View article: Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo
Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo Open
Synchrotron radiation-based tomography yields the micro-anatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compared the perf…