Bert Ruiter
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View article: Immunomodulatory metabolites in <scp>I</scp> g <scp>E</scp> ‐mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling
Immunomodulatory metabolites in <span>I</span> g <span>E</span> ‐mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling Open
Background The immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE‐mediated food allergy are unknown. Objective To identify novel pathways associated with tolerance in food allergy, we …
View article: Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling
Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling Open
Background The immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown. Objective To identify novel pathways associated with tolerance in food allergy, we …
View article: Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries
Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries Open
High-throughput 3’ single-cell RNA-Sequencing (scRNA-Seq) allows for cost-effective, detailed characterization of thousands of individual immune cells from healthy and diseased tissues. Current techniques, however, are limited in their abi…
View article: Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells
Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells Open
Food allergy affects an estimated 8% of children in the United States. Oral immunotherapy (OIT) is a recently approved treatment, with outcomes ranging from sustained tolerance to food allergens to no apparent benefit. The immunological un…
View article: Clonally expanded, GPR15-expressing pathogenic effector T <sub>H</sub> 2 cells are associated with eosinophilic esophagitis
Clonally expanded, GPR15-expressing pathogenic effector T <sub>H</sub> 2 cells are associated with eosinophilic esophagitis Open
T H 2 cells in eosinophilic esophagitis exhibit clonotypic features of an antigen-specific response and enhanced esophagus-homing ability.
View article: Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells
Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells Open
Food allergy affects an estimated 8% of children in the US, with increasing severity and global prevalence 1 . Oral immunotherapy (OIT) is a recently approved treatment with outcomes ranging from sustained tolerance to food allergen to no …
View article: Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals
Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals Open
Recent advances in high-throughput T cell receptor (TCR) sequencing have allowed for new insights into the human TCR repertoire. However, methods for capturing antigen-specific repertoires remain an area of development. Here, we describe a…
View article: Identification of antigen-specific TCR sequences using a strategy based on biological and statistical enrichment in unselected subjects
Identification of antigen-specific TCR sequences using a strategy based on biological and statistical enrichment in unselected subjects Open
Recent advances in high-throughput T cell receptor (TCR) sequencing have allowed for new insights into the TCR repertoire. However, methods for capturing antigen-specific repertoires remain an area of development. Here, we describe a novel…
View article: Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries
Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries Open
High-throughput 3’ single-cell RNA-Sequencing (scRNA-Seq) allows for cost-effective, detailed characterization of thousands of individual immune cells from healthy and diseased tissues. Current techniques, however, are limited in their abi…
View article: Vitamins A and D have antagonistic effects on expression of effector cytokines and gut‐homing integrin in human innate lymphoid cells
Vitamins A and D have antagonistic effects on expression of effector cytokines and gut‐homing integrin in human innate lymphoid cells Open
Summary Background Retinoic acid ( RA ), the main biologically active metabolite of vitamin A, is known to promote gut homing of lymphocytes, as well as various regulatory and effector immune responses. In contrast, the active form of vita…