Bert Sakmann
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View article: Amyloid β–dependent neuronal silencing through synaptic decoupling
Amyloid β–dependent neuronal silencing through synaptic decoupling Open
Amyloid β (Aβ)-dependent circuit dysfunction in Alzheimer’s disease (AD) is determined by a puzzling mix of hyperactive and inactive (“silent”) brain neurons. Recent studies identified excessive glutamate accumulation as a key Aβ-dependent…
View article: Sparks in the Brain: The Story of Ion Channels and Nerve Cells
Sparks in the Brain: The Story of Ion Channels and Nerve Cells Open
Understanding the communication between nerve cells in the brain is key to understanding how the brain works. Communication between nerve cells involves chemical messages sent from one cell that get translated into electrical activity in t…
View article: High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch
High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch Open
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-type…
View article: A theory for the emergence of neocortical network architecture
A theory for the emergence of neocortical network architecture Open
Developmental programs that guide neurons and their neurites into specific subvolumes of the mammalian neocortex give rise to lifelong constraints for the formation of synaptic connections. To what degree do these constraints affect cortic…
View article: Organization and somatotopy of corticothalamic projections from L5B in mouse barrel cortex
Organization and somatotopy of corticothalamic projections from L5B in mouse barrel cortex Open
Significance In the somatosensory system, signals are transduced from peripheral sensors up to the cerebral cortex in a topographic manner, meaning that the relative spatial organization of the sensory receptors is represented by a map in …
View article: BACE inhibition-dependent repair of Alzheimer’s pathophysiology
BACE inhibition-dependent repair of Alzheimer’s pathophysiology Open
Significance The accumulation of amyloid-β (Aβ) proteins in the brain contributes to Alzheimer´s disease (AD). Reducing Aβ by inhibiting its production with a β-secretase (BACE) inhibitor represents a novel mechanism for treating AD; howev…
View article: Anatomical Correlates of Local, Translaminar, and Transcolumnar Inhibition by Layer 6 GABAergic Interneurons in Somatosensory Cortex
Anatomical Correlates of Local, Translaminar, and Transcolumnar Inhibition by Layer 6 GABAergic Interneurons in Somatosensory Cortex Open
In the vibrissal area of rodent somatosensory cortex, information on whisker stimulation is processed by neuronal networks in a corresponding cortical column. To understand how sensory stimuli are represented in a column, it is essential t…
View article: From single cells and single columns to cortical networks: dendritic excitability, coincidence detection and synaptic transmission in brain slices and brains
From single cells and single columns to cortical networks: dendritic excitability, coincidence detection and synaptic transmission in brain slices and brains Open
Although patch pipettes were initially designed to record extracellularly the elementary current events from muscle and neuron membranes, the whole‐cell and loose cell‐attached recording configurations proved to be useful tools for examina…
View article: Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo
Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo Open
The cortex connects to the thalamus via extensive corticothalamic (CT) pathways, but their function in vivo is not well understood. We investigated "top-down" signaling from cortex to thalamus via the cortical layer 5B (L5B) to posterior m…
View article: Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites
Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites Open
Significance Even the simplest sensory stimulus activates millions of synapses across the cortex. How neurons integrate these highly specialized, but noisy synaptic input patterns to generate robust electrophysiological responses—that ulti…
View article: Deep two-photon brain imaging with a red-shifted fluorometric Ca <sup>2+</sup> indicator
Deep two-photon brain imaging with a red-shifted fluorometric Ca <sup>2+</sup> indicator Open
Significance We introduce a two-photon imaging method with improved depth penetration for the recording of neuronal activity with single-cell resolution in the intact brain of living animals. This method relies on the use of the fluorometr…
View article: Beyond Columnar Organization: Cell Type- and Target Layer-Specific Principles of Horizontal Axon Projection Patterns in Rat Vibrissal Cortex
Beyond Columnar Organization: Cell Type- and Target Layer-Specific Principles of Horizontal Axon Projection Patterns in Rat Vibrissal Cortex Open
Vertical thalamocortical afferents give rise to the elementary functional units of sensory cortex, cortical columns. Principles that underlie communication between columns remain however unknown. Here we unravel these by reconstructing in …
View article: Synaptic Conductance Estimates of the Connection Between Local Inhibitor Interneurons and Pyramidal Neurons in Layer 2/3 of a Cortical Column
Synaptic Conductance Estimates of the Connection Between Local Inhibitor Interneurons and Pyramidal Neurons in Layer 2/3 of a Cortical Column Open
Stimulation of a principal whisker yields sparse action potential (AP) spiking in layer 2/3 (L2/3) pyramidal neurons in a cortical column of rat barrel cortex. The low AP rates in pyramidal neurons could be explained by activation of inter…