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View article: Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
Supplementary Figure S1. Description of the CCHD-PPGL cohort of 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary Figure S2. Summary of the clinical features of patients with CCHD-PPGL. Supplementary Figure S3. EPAS1 mut…
View article: Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
Supplementary Tables Supplementary Table S1. Clinical and Tumoral Data from CCHD-PPGL patients. Supplementary Table S2. Selection inference in the PPGL (TCGA, non-CCHD) and CCHD-PPGL cohort. Supplementary Table S3. Cancer Cell Fraction of …
View article: Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
Supplementary Tables Supplementary Table S1. Clinical and Tumoral Data from CCHD-PPGL patients. Supplementary Table S2. Selection inference in the PPGL (TCGA, non-CCHD) and CCHD-PPGL cohort. Supplementary Table S3. Cancer Cell Fraction of …
View article: Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
Supplementary Figure S1. Description of the CCHD-PPGL cohort of 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary Figure S2. Summary of the clinical features of patients with CCHD-PPGL. Supplementary Figure S3. EPAS1 mut…
View article: Data from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Data from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified EPAS1, a gene critical for hypoxia adaptation in populations such as Tibetans and Sherpas, as playing a similar…
View article: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes Open
This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified EPAS1, a gene critical for hypoxia adaptation in populations such as Tibetans and Sherpas, as playing a similar…
View article: Evaluation of Platonia insignis Mart. (Bacuri Butter) and Biopolymers from the Puree of Allium cepa L. (Yellow Onion Bulb) for Wound Healing in Horses
Evaluation of Platonia insignis Mart. (Bacuri Butter) and Biopolymers from the Puree of Allium cepa L. (Yellow Onion Bulb) for Wound Healing in Horses Open
Background/Objectives: Skin injuries are common in the equine clinical practice, requiring effective treatment to support natural healing. Bacuri butter is gaining attention for its potential in wound healing and its anti-inflammatory, ant…
View article: In vivo study of pulmonary artery remodeling and pulsatility in long Fontan patient
In vivo study of pulmonary artery remodeling and pulsatility in long Fontan patient Open
Background Pulmonary vasculopathy associated with Fontan circulation is a relatively unexplored entity that could have clinical and therapeutic implications. Purpose Our aim was to evaluate the physiology of the pulmonary artery in patient…
View article: Stenting of aortic coarctation before coronary artery bypass surgery in an adult with acute myocardial infarction: a case report
Stenting of aortic coarctation before coronary artery bypass surgery in an adult with acute myocardial infarction: a case report Open
Background Aortic coarctation is a major risk factor for high blood pressure and atherosclerotic disease development. Evidence is lacking regarding the treatment of acute coronary syndrome in patients with untreated aortic coarctation. Cas…
View article: Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes
Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes Open
EPAS1 HIF2α is the primary gene implicated in systemic hypoxia adaptation. Conversely, aberrantly activated EPAS1 HIF2α acts as a tumor driver against which anti-tumor therapeutics are proven effective. We elucidated connections between ad…
View article: Progestogen only contraception in women with congenital heart disease
Progestogen only contraception in women with congenital heart disease Open
Because of their safety and efficacy, IUD-IPs and SI-IPs should be considered as first-line contraception in patients with CHD.
View article: Usefulness of the baseline risk assessment guidelines to predict cancer therapy-related cardiac dysfunction in early-stage HER2 positive breast cancer
Usefulness of the baseline risk assessment guidelines to predict cancer therapy-related cardiac dysfunction in early-stage HER2 positive breast cancer Open
Introduction Treatment of HER 2-positive breast cancer (HER2+BC) with anthracyclines and HER2-targeted therapy is associated with a high incidence of cancer therapy-related cardiac dysfunction (CTRCD). Baseline risk assessment is crucial t…
View article: Predictors of right atrial dilatation and long-term function after right ventricular outflow tract surgical repair: Quantification of restrictive physiology matters
Predictors of right atrial dilatation and long-term function after right ventricular outflow tract surgical repair: Quantification of restrictive physiology matters Open
VTI-EDFF linearly correlated with the degree of RA dilation and deformation; EDFF quantification as against qualitative assessment may be considered a non-invasive tool for diastolic RV dysfunction.
View article: Feasibility and mid-term results of transcatheter pulmonary valve replacement using Edwards-Sapien valves
Feasibility and mid-term results of transcatheter pulmonary valve replacement using Edwards-Sapien valves Open
Background Transcatheter pulmonary valve replacement (TPVR) is an alternative to surgery in certain patients with pulmonary valve dysfunction. When feasible, a percutaneous approach is increasingly common in congenital heart disease (CHD).…
View article: The coronavirus disease 2019 pandemic among adult congenital heart disease patients: findings of a one-year multicentric, international study
The coronavirus disease 2019 pandemic among adult congenital heart disease patients: findings of a one-year multicentric, international study Open
Introduction One year after the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, the evidence on outcomes among adults with congenital heart disease (ACHD) is still limited. Purpose We aimed to compare patient characteristics…
View article: Clinical outcome of COVID-19 in patients with adult congenital heart disease
Clinical outcome of COVID-19 in patients with adult congenital heart disease Open
Aims Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on ex…
View article: Left main coronary artery compression by a large pulmonary artery aneurysm in the absence of pulmonary hypertension: a case report
Left main coronary artery compression by a large pulmonary artery aneurysm in the absence of pulmonary hypertension: a case report Open
Comprehensive medical evaluation of symptomatic patients with PA dilatation, even in the absence of PH, is key to rule out the possibility of serious complications as soon as possible.
View article: Intra-atrial re-entrant tachycardia in congenital heart disease: types and relation of isthmus to atrial voltage
Intra-atrial re-entrant tachycardia in congenital heart disease: types and relation of isthmus to atrial voltage Open
Intra-atrial re-entrant tachycardia (IART) is a frequent and severe complication in patients with congenital heart disease (CHD). Cavotricuspid isthmus (CTI)-related IART is the most frequent mechanism. However, due to fibrosis and surgica…
View article: Intra-atrial re-entrant tachycardia in patients with congenital heart disease: factors associated with disease severity
Intra-atrial re-entrant tachycardia in patients with congenital heart disease: factors associated with disease severity Open
In our series of 94 CHD patients with a high proportion of moderately to highly complex cardiac defects, severe consequences of IART were frequent. Transposition of the great arteries with systemic right ventricle and severe dilation of Vs…
View article: Life‐threatening and life‐saving inappropriate implantable cardioverter defibrillator shocks
Life‐threatening and life‐saving inappropriate implantable cardioverter defibrillator shocks Open
Key Clinical Message An implantable cardioverter defibrillator (ICD) lead dislodgement into the right atrium is a dangerous situation, particularly in patients in atrial fibrillation because atrial fibrillation can be sensed as ventricular…
View article: Plasma bilirubin values on admission and ventricular remodeling after a first anterior ST-segment elevation acute myocardial infarction
Plasma bilirubin values on admission and ventricular remodeling after a first anterior ST-segment elevation acute myocardial infarction Open
Admission bilirubin values are not related to LVEDV or ejection fraction progression after a first anterior STEMI and do not predict adverse ventricular remodeling. Key messages Bilirubin levels are inversely related to cardiovascular dise…