Berta Sanchez‐Laorden
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View article: Protocol for generation, quantification, and phenotyping of brain metastases in preclinical mouse models
Protocol for generation, quantification, and phenotyping of brain metastases in preclinical mouse models Open
The field of brain metastasis is rapidly expanding, yet no consensus exists on the most reliable quantification approach. We present a protocol for assessing metastatic burden in mice following intracarotid injection of tumor cells. We des…
View article: Schwann cells in regeneration and cancer: an epithelial–mesenchymal transition perspective
Schwann cells in regeneration and cancer: an epithelial–mesenchymal transition perspective Open
In the peripheral nervous system, glial cells, known as Schwann cells (SCs), are responsible for supporting and maintaining nerves. One of the most important characteristics of SCs is their remarkable plasticity. In various injury contexts…
View article: Melanoma innervation is associated with cancer progression in a zebrafish xenograft model
Melanoma innervation is associated with cancer progression in a zebrafish xenograft model Open
The peripheral nervous system has a key role in regulating tumour biology in different types of cancer. Here, by modelling aggressive melanoma in larval zebrafish xenografts, we highlight the dynamics of tumour innervation in the tumour mi…
View article: Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy Open
Resistance of melanoma to targeted therapy and immunotherapy is linked to metabolic rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF inhibitor (BRAFi) treatment contributes to acquired therapy resista…
View article: Neuronal Cannabinoid CB1 Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling
Neuronal Cannabinoid CB1 Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling Open
Melanoma is one of the deadliest forms of cancer. Most melanoma deaths are caused by distant metastases in several organs, especially the brain, the so-called melanoma brain metastases (MBMs). However, the precise mechanisms that sustain t…
View article: Supplementary Figure 3 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 3 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 3 PDF file - 498K, Histopathology data are presented to confirm that CNS tumors in our mice are malignant melanomas
View article: Supplementary Table S2 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S2 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 67K,MIG6-ERRFI1 differentially expressed phosphopeptides in A375(X) vs A375(X)/R cells
View article: Supplementary Table S5 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S5 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 44K,SFK phosphorylation intensity in patient sample following treatment with vehicle or dasatinib as indicated
View article: Supplementary Table S4 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S4 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 60K, Proteins with differentially regulated phosphopeptides corresponding to the cytoskeleton group according to DAVID GO analysis
View article: Supplementary Figure S2 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Figure S2 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 116K, Photomicrographs showing phospho-EGFR staining in patients' tumours
View article: Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 4 PDF file - 39K, Sequencing of RT-PCR amplified cDNA is presented to show that NRASG12D is expressed in the CNS tumors of our mice
View article: Supplementary Material from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Material from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 124K, Contains extended Materials and Methods for the manuscript
View article: Supplementary Figure S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Figure S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 64K, Western blotting for phospho-EGFR in tumour xenografts
View article: Supplementary Figure Legends from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Figure Legends from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 77K,Supplementary Figure Legends for Supplementary Figures S1 and S2
View article: Supplementary Figure 1 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 1 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 1 PDF file - 795K, Data are presented to show that NRASG12D does not induce melanoma when expressed in the melanocytes of adult mice
View article: Supplementary Table S3 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S3 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 49K,SFK phosphorylation in BRAF inhibitor-resistant tumours following dasatinib treatment
View article: Supplementary Material from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Material from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 124K, Contains extended Materials and Methods for the manuscript
View article: Supplementary Figure S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Figure S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 64K, Western blotting for phospho-EGFR in tumour xenografts
View article: Supplementary Figure 2 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 2 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 2 PDF file - 394K,Data are presented to show that congenital expression of NRASG12D in mouse melanocytes does not affect eyes or heart development
View article: Supplementary Figure 2 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 2 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 2 PDF file - 394K,Data are presented to show that congenital expression of NRASG12D in mouse melanocytes does not affect eyes or heart development
View article: Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes
Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes Open
Supplementary Figure 4 PDF file - 39K, Sequencing of RT-PCR amplified cDNA is presented to show that NRASG12D is expressed in the CNS tumors of our mice
View article: Data from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Data from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–SRC family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In addition to driving proliferation of resistant cells, this pathwa…
View article: Supplementary Table S5 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S5 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 44K,SFK phosphorylation intensity in patient sample following treatment with vehicle or dasatinib as indicated
View article: Supplementary Table S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Supplementary Table S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
PDF file - 201K,Differentially expressed phosphopeptides in A375(X) vs A375(X)/R cells
View article: Data from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Data from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma Open
We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–SRC family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In addition to driving proliferation of resistant cells, this pathwa…
View article: Supplementary Figures S1 - S9, Table S1 from The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα
Supplementary Figures S1 - S9, Table S1 from The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα Open
Supplementary Figures S1 - S9, Table S1. Supplementary Figure S1 (related to Figure 1) shows TNFR expression in melanoma cells. Supplementary Figure S2 (related to Figure 2) shows an NF-κBα binding site in the MITF promoter and MITF target…