Explanipedia

Heads-Up Three-Dimensional Viewing Systems in Vitreoretinal Surgery: An Updated Perspective Open

Peyman Razavi, Bertan Cakir, Grace Baldwin, Donald J. D’Amico, John B. Miller · 2023

Three-Dimensional (3D) heads-up visualization systems have significantly advanced vitreoretinal surgery, providing enhanced detail and improved ergonomics. This review discusses the application of 3D systems in vitreoretinal surgery, their…

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation Open

Émilie Heckel, Gaël Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das , et al. · 2022

Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of…

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration Open

Zhongjie Fu, Chenxi Qiu, Gaël Cagnone, Yohei Tomita, Shuo Huang , et al. · 2021

Vitreous metabolomics profiling of proliferative diabetic retinopathy Open

Yohei Tomita, Gaël Cagnone, Zhongjie Fu, Bertan Cakir, Yumi Kotoda , et al. · 2020

IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants Open

Bertan Cakir, William Hellström, Yohei Tomita, Zhongjie Fu, Raffael Liegl , et al. · 2020

BACKGROUNDHyperglycemia, insulin insensitivity, and low IGF1 levels in extremely preterm infants are associated with an increased risk of retinopathy of prematurity (ROP), but the interactions are incompletely understood.METHODSIn 117 extr…

An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis Open

Yohei Tomita, Zhuo Shao, Bertan Cakir, Yumi Kotoda, Zhongjie Fu , et al. · 2020

Pathological choroidal angiogenesis, a salient feature of age-related macular degeneration, leads to vision impairment and blindness. Endothelial cell (EC) proliferation assays using human retinal microvascular endothelial cells (HRMECs) o…

Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid Open

Michael Reich, Daniel Boehringer, Kai Rothaus, Bertan Cakir, Felicitas Bucher , et al. · 2020

Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice Open

Yohei Tomita, Bertan Cakir, Chi‐Hsiu Liu, Zhongjie Fu, Shuo Huang , et al. · 2020

Targeting Neurovascular Interaction in Retinal Disorders Open

Zhongjie Fu, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang , et al. · 2020

The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Cl…

Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models Open

Yohei Tomita, Zhongjie Fu, Zhongxiao Wang, Bertan Cakir, Steve S. Cho , et al. · 2020

The aim of the current study was to investigate the impact of long-acting fibroblast growth factor 21 (FGF21) on retinal vascular leakage utilizing machine learning and to clarify the mechanism underlying the protection. To assess the effe…

Characterisation of vascular changes in different stages of Stargardt disease using double swept-source optical coherence tomography angiography Open

Michael Reich, Andreas Glatz, Bertan Cakir, Daniel Böhringer, Stefan J. Lang , et al. · 2019

Objective To describe vascular changes in different stages of Stargardt disease (STGD) via double swept-source optical coherence tomography angiography. Methods and analysis Prospective, cross-sectional case–control study. Twenty-three pat…

Longitudinal Analysis of the Choriocapillaris Using Optical Coherence Tomography Angiography Reveals Subretinal Fluid as a Substantial Confounder in Patients with Acute Central Serous Chorioretinopathy Open

Michael Reich, Daniel Böhringer, Bertan Cakir, Felicitas Bucher, Moritz Claudius Daniel , et al. · 2019

The temporospatial association between SRF and reduced OCTA signal from the CC demonstrates that fluid might be a significant confounder for OCTA analysis in patients with CSC. CSC patients with complete absorption of the SRF at follow-up,…

Dyslipidemia in retinal metabolic disorders Open

Zhongjie Fu, Chuck T. Chen, Gaël Cagnone, Émilie Heckel, Ye Sun , et al. · 2019

The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are con…

Optical Coherence Tomography Angiography in Stargardt disease Open

Michael Reich, Andreas Glatz, Bertan Cakir, Daniel Boehringer, Wolf A. Lagrèze , et al. · 2019

Long-acting FGF21 inhibits retinal vascular leakage in vivo and in vitro model Open

Yohei Tomita, Zhongjie Fu, Bertan Cakir, Ye Sun, Zongxiao Wang , et al. · 2019

A negative immune regulator SOCS3 controls laser-induced choroidal neovascularization Open

Ye Sun, Chi‐Hsiu Liu, Yan Gong, Bertan Cakir, Steve K. Cho , et al. · 2019

Insulin insensitivity in very preterm infants is associated with decreased levels of IGF-1 and increased risk for ROP Open

Bertan Cakir, Raffael Liegl, Ingrid Hansen‐Pupp, Gunnel Hellgren, Yohei Tomita , et al. · 2019

Acute unilateral maculopathy associated with adult onset of hand, foot and mouth disease: a case report Open

Michael Reich, Bertan Cakir, Stevan Cvetkoski, Stefan J. Lang, Andreas Stahl , et al. · 2019

OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis Open

Bertan Cakir, Michael Reich, Stefan J. Lang, Anima Bühler, Christoph Ehlken , et al. · 2019

The decreased OCTA signal in the area of SRF in acute CSC could be evidence of localized CC hypoperfusion or due to shadowing artifacts. The missing CC OCTA changes in altered RPE adjacent to atrophy argues against CC injury. Studies with …

Impact of angiogenic activation and inhibition on miRNA profiles of human retinal endothelial cells Open

Johanna M. Walz, Thomas Wecker, Pei pei Zhang, Bertan Cakir, Bjoern Gruening , et al. · 2019

In this study we characterized the miRNA profile of HRMVECs under resting, angiogenic and anti-angiogenic conditions and identified several miRNAs of potential pathophysiologic importance for angioproliferative retinal diseases. Our result…

Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival Open

Tristan Reuer, Ann-Charlott Schneider, Bertan Cakir, Anima Bühler, Johanna M. Walz , et al. · 2018

Sema3F is a novel mediator of corneal avascularity with potent anti-lymphangiogenic properties. Topical treatment with Sema3F eye drops may help to limit corneal vascularization and improve outcomes in high-risk keratoplasty patients.

Thrombocytopenia is associated with severe retinopathy of prematurity Open

Bertan Cakir, Raffael Liegl, Gunnel Hellgren, Pia Lundgren, Ye Sun , et al. · 2018

Retinopathy of prematurity (ROP) is characterized by abnormal retinal neovascularization in response to vessel loss. Platelets regulate angiogenesis and may influence ROP progression. In preterm infants, we assessed ROP and correlated with…

IGF-1 in relation to early postnatal plasma glucose concentrations in very preterm infants Open

Bertan Cakir, Raffael Liegl, Ingrid Hansen‐Pupp, Gunnel Hellgren, Alexander Poblete , et al. · 2018

Photoreceptor glucose metabolic modulation by adiponectin prevents hyperglycemic ROP Open

Zhongjie Fu, Chatarina Löfqvist, Raffael Liegl, Zhongxiao Wang, Ye Sun , et al. · 2018

FGF21 restores photoreceptor function in type 1 diabetic mice Open

Ricky Z. Cui, Zhongjie Fu, Zhongxiao Wang, Chi‐Hsiu Liu, Yan Gong , et al. · 2018

Myeloid precursors develop into endothelial progenitor cells modulated by SOCS3 Open

Ye Sun, Pingzhu Zhou, Chi‐Hsiu Liu, Yan Gong, Bertan Cakir , et al. · 2018

Consensus guidelines for the use and interpretation of angiogenesis assays Open

Patrycja Nowak‐Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C. Aplin , et al. · 2018

Gene expression profiling in a mouse model of retinal vein occlusion induced by laser treatment reveals a predominant inflammatory and tissue damage response Open

Gottfried Martin, David Conrad, Bertan Cakir, Günther Schlunck, Hansjürgen Agostini · 2018

The laser-induced RVO mouse model is characterized by a predominant general inflammatory and tissue damage response, which may obscure distinct hypoxia- and angiogenesis-related effects. A non-occlusive laser treatment control is essential…

Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice Open

Zhongjie Fu, Zhongxiao Wang, Chi‐Hsiu Liu, Yan Gong, Bertan Cakir , et al. · 2018

Retinal neuronal abnormalities occur before vascular changes in diabetic retinopathy. Accumulating experimental evidence suggests that neurons control vascular pathology in diabetic and other neovascular retinal diseases. Therefore, normal…

A machine learning approach for automated assessment of retinal vasculature in the oxygen induced retinopathy model Open

Javier Mazzaferri, Bruno Larrivée, Bertan Cakir, Przemysław Sapieha, Santiago Costantino · 2018

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