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View article: Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation
Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation Open
View article: Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay
Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay Open
Nucleotide sequences along a gene provide instructions to transcriptional and cotranscriptional machinery allowing genome expansion into the transcriptome. Nucleotide sequence can often be shared between two genes and in some occurrences, …
View article: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency Open
Enhancers bind transcription factors, chromatin regulators, and non-coding transcripts to modulate the expression of target genes. Here, we report 3D genome structures of single mouse ES cells as they are induced to exit pluripotency and t…
View article: Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment
Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment Open
View article: The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells
The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Open
As cells exit the pluripotent state and begin to commit to a specific lineage they must activate genes appropriate for that lineage while silencing genes associated with pluripotency and preventing activation of lineage-inappropriate genes…
View article: Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of<i>Kcnk9</i>during mouse neural commitment
Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of<i>Kcnk9</i>during mouse neural commitment Open
How constitutive allelic methylation at imprinting control regions (ICRs) interacts with other levels of regulation to drive timely parental allele-specific expression along large imprinted domains remains partially understood. To gain ins…
View article: Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay
Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay Open
Nucleotide sequences along a gene provide instructions to transcriptional and co-transcriptional machinery allowing genome expansion into the transcriptome. Interestingly, nucleotide sequence can often be shared between two genes and in so…
View article: The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells
The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Open
As cells exit the pluripotent state and begin to commit to a specific lineage they must activate genes appropriate for that lineage while silencing genes associated with pluripotency and preventing activation of lineage-inappropriate genes…
View article: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency Open
Summary Enhancers are genomic DNA sequences that bind transcription factors, chromatin regulators and non-coding transcripts to modulate the expression of target genes. They have been found to act from different locations relative to a gen…
View article: The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation Open
Glioblastomas represent approximatively half of all gliomas and are the most deadly and aggressive form. Their therapeutic resistance and tumor relapse rely on a subpopulation of cells that are called Glioma Stem Cells (GSCs). Here, we inv…
View article: Intragenic CpG Islands and Their Impact on Gene Regulation
Intragenic CpG Islands and Their Impact on Gene Regulation Open
The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene…
View article: Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms
Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms Open
Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA meth…
View article: Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart Open
Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart where it is encoded by Ddc_exon1a , a tissue-specific paternally expressed imprinted gene. Ddc_exon1a shares an imprinting control region (ICR) with the imprinted…
View article: Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing Open
Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development and differentiation. Epigenetic marks such as trimethylation of histone H3 lysine 36 (H3K36me3) and DNA me…
View article: A novel thrombopoietin (<i>THPO</i>) mutation altering mRNA splicing in a case of familial thrombocytosis
A novel thrombopoietin (<i>THPO</i>) mutation altering mRNA splicing in a case of familial thrombocytosis Open
International audience
View article: TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment Open
View article: Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing Open
Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development and differentiation. Epigenetic factors such as trimethylation of histone H3 lysine 36 (H3K36me3) and DNA …
View article: Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration
Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration Open
Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activati…
View article: Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive
Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive Open
Parental allele-specific expression of imprinted genes is mediated by imprinting control regions (ICRs) that are constitutively marked by DNA methylation imprints on the maternal or paternal allele. Mono-allelic DNA methylation is strictly…