Bertram Scheller
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View article: Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons
Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons Open
Ketamine, an NMDA receptor (NMDA-R) antagonist, produces psychotomimetic effects when administered in sub-anesthetic dosages. While previous research suggests that Ketamine alters the excitation/inhibition (E/I)-balance in cortical microci…
View article: Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence
Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence Open
Cannabis abuse has been linked to acute psychotic symptoms as well as to the development of schizophrenia. Although the association has been well described, causation has not yet been investigated. Therefore, we investigated whether cannab…
View article: Learning in the Single-Cell Organism Physarum polycephalum: Effect of Propofol
Learning in the Single-Cell Organism Physarum polycephalum: Effect of Propofol Open
Propofol belongs to a class of molecules that are known to block learning and memory in mammals, including rodents and humans. Interestingly, learning and memory are not tied to the presence of a nervous system. There are several lines of …
View article: Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study
Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study Open
Objectives Postoperative delirium (POD) is a common complication after elective cardiac surgery. Recent evidence indicates that a disruption in the normal activity of the cholinergic system may be associated with delirium. Design Prospecti…
View article: Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia
Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia Open
Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated as a possible mechanism underlying cognitive deficits and aberrant neuronal dynamics in schizophrenia. To test this hypothesis, we first administered a sub-anaes…
View article: The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury
The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury Open
Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis. While tubular…
View article: S42. KETAMINE DYSREGULATES TASK-RELATED NEURAL OSCILLATIONS IN THALAMO-CORTICAL CIRCUITS: IMPLICATIONS FOR PATHOPHYSIOLOGICAL THEORIES OF VISUAL-PERCEPTUAL DEFICITS IN SCHIZOPHRENIA
S42. KETAMINE DYSREGULATES TASK-RELATED NEURAL OSCILLATIONS IN THALAMO-CORTICAL CIRCUITS: IMPLICATIONS FOR PATHOPHYSIOLOGICAL THEORIES OF VISUAL-PERCEPTUAL DEFICITS IN SCHIZOPHRENIA Open
Hypofunction of the N-methyl-D-aspartate receptor (NMDA-R) has been implicated as a possible mechanism underlying cognitive deficits and aberrant neuronal dynamics in schizophrenia (ScZ). In a single-blind cross-over design, 14 participant…
View article: Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney
Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney Open
Acute kidney injury remains an important cause of renal dysfunction. In this context, Toll‐like receptors have been demonstrated to play a critical role in the induction of innate and inflammatory responses. Among these, Toll‐like receptor…
View article: Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle
Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle Open
Our data reveal a central role of the innate immune system, namely Toll-like receptor 3, to mediate angiogenesis upon release of cytoplasmic RNAs by mechanotransduction of SWT.
View article: Individual Organ Failure and Concomitant Risk of Mortality Differs According to the Type of Admission to ICU – A Retrospective Study of SOFA Score of 23,795 Patients
Individual Organ Failure and Concomitant Risk of Mortality Differs According to the Type of Admission to ICU – A Retrospective Study of SOFA Score of 23,795 Patients Open
The dynamic evolution of OD/OF within 72h after ICU admission and mortality differed between patients depending on their types of admission. This has to be considered to exclude a systematic bias during multi-center trials.
View article: Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical–Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings
Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical–Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings Open
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the effects of ketamine, a dissociative anesthetic and NMDA-R antagonist,…