Bertrand Calippe
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View article: Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization
Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization Open
Experimental BRVO leads to acute endothelial cells apoptosis and increased permeability. Subsequently the upstream vascular network remains destabilized, characterized by pericyte dropout, un-physiologically high endothelial cells turnover…
View article: Upregulation of P2RX7 in<i>Cx3cr1</i>-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration
Upregulation of P2RX7 in<i>Cx3cr1</i>-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration Open
Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1 -deficient mice develop age- and stress-…
View article: Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration.
Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration. Open
Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1-deficient mice develop age- and stress- …
View article: Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration
Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration Open
Physiologically, the retinal pigment epithelium ( RPE ) expresses immunosuppressive signals such as FAS ligand ( FASL ), which prevents the accumulation of leukocytes in the subretinal space. Age‐related macular degeneration ( AMD ) is ass…
View article: Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice.
Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. Open
The observations from this study suggest that cytotoxic CD8(+) T lymphocytes might participate in choroidal and RPE degeneration and that modulation of T lymphocyte recruitment might be a novel strategy to reduce choroidoretinal dysfunctio…