Berwyck L. J. Poad
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View article: Halving the Barrier to Gas-Phase Oxidation of Bromide by Ozone
Halving the Barrier to Gas-Phase Oxidation of Bromide by Ozone Open
Recent atmospheric measurements have indicated that bromine and iodine may be responsible for up to 72% of halogen-induced ozone loss near the tropopause. Whilst the neutral bromine and iodine radicals have well-described reaction pathways…
View article: Electrostatically tuning radical addition and atom abstraction reactions with distonic radical ions
Electrostatically tuning radical addition and atom abstraction reactions with distonic radical ions Open
Charged functional groups can control gas-phase radical reactions in a predictable and tuneable manner by creating an internal oriented electric field that modulates the rate-limiting transition state.
View article: Targeting <i>de novo</i> lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma
Targeting <i>de novo</i> lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with few treatment options and poor survivability. In this work we sought to characterise metabolic adaptations to gemcitabine (GEMC)-based chemotherapy exposure to dis…
View article: Making OzID go FFASTer: Combining stable-isotope tagging with ozone-induced dissociation to uncover changes in fatty acid unsaturation within neurosecretory cells
Making OzID go FFASTer: Combining stable-isotope tagging with ozone-induced dissociation to uncover changes in fatty acid unsaturation within neurosecretory cells Open
View article: Gas-Phase Phenyl Radical + O<sub>2</sub> Reacts via a Submerged Transition State
Gas-Phase Phenyl Radical + O<sub>2</sub> Reacts via a Submerged Transition State Open
In the gas-phase chemistry of the atmosphere and automotive fuel combustion, peroxyl radical intermediates are formed following O2 addition to carbon-centered radicals which then initiate a complex network of radical reactions t…
View article: Deep Characterisation of the <i>sn‐</i>Isomer Lipidome Using High‐Throughput Data‐Independent Acquisition and Ozone‐Induced Dissociation**
Deep Characterisation of the <i>sn‐</i>Isomer Lipidome Using High‐Throughput Data‐Independent Acquisition and Ozone‐Induced Dissociation** Open
In recent years there has been a significant interest in the development of innovative lipidomics techniques capable of resolving lipid isomers. To date, methods applied to resolving sn ‐isomers have resolved only a limited number of speci…
View article: Main chain selective polymer degradation: controlled by the wavelength and assembly
Main chain selective polymer degradation: controlled by the wavelength and assembly Open
A pair of cyclic monomers enables selective photocleavage at different wavelengths and self-assembly into photoreactive micelles, which alter depolymerization products.
View article: Cation induced changes to the structure of cryptophane cages
Cation induced changes to the structure of cryptophane cages Open
Ion mobility captures key processes underpinning encapsulation in cryptophane cages, including surprising structures not observed before using traditional analysis.
View article: A High-Throughput Data-Independent Acquisition Workflow for Deep Characterisation of the<i>sn</i>-Isomer Lipidome
A High-Throughput Data-Independent Acquisition Workflow for Deep Characterisation of the<i>sn</i>-Isomer Lipidome Open
We report a workflow based on ozone-induced dissociation for untargeted characterization of hundreds of sn- resolved glycerophospholipid isomers from biological extracts in under 20 minutes, coupled with an automated data analysis pipeline…
View article: Isomer-Resolved Mass Spectrometry Imaging of Acidic Phospholipids
Isomer-Resolved Mass Spectrometry Imaging of Acidic Phospholipids Open
The biological functions of lipids are entirely dependent on their molecular structures with even small changes in structure─such as different sites of unsaturation─providing critical markers for changes in the underlying metabolism. Conve…
View article: Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome
Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome Open
Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary analysis by incomplete separation and the absence of sufficiently …
View article: CCDC 2235695: Experimental Crystal Structure Determination
CCDC 2235695: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Revolutions in lipid isomer resolution: application of ultra-high resolution ion mobility to reveal lipid diversity
Revolutions in lipid isomer resolution: application of ultra-high resolution ion mobility to reveal lipid diversity Open
Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry ap-proaches, leading to a significant underestimation of structural diversity within the lipidome. While ion-mobility coupled to mass …
View article: Diastereomer Resolution of M<sub>4</sub>L<sub>6</sub> Coordination Cages by Ultra‐High‐Resolution Ion‐Mobility Mass Spectrometry
Diastereomer Resolution of M<sub>4</sub>L<sub>6</sub> Coordination Cages by Ultra‐High‐Resolution Ion‐Mobility Mass Spectrometry Open
Coordination cages can be used for enantio‐ and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra‐high‐resoluti…
View article: Establishing carbon–carbon double bond position and configuration in unsaturated fatty acids by gas-phase infrared spectroscopy
Establishing carbon–carbon double bond position and configuration in unsaturated fatty acids by gas-phase infrared spectroscopy Open
3-Pyridylcarbinol ester derivatization introduces a universal probe for cryogenic gas-phase infrared spectroscopy of fatty acids that enables assignment of the position and configuration of carbon–carbon double bonds even in the presence o…
View article: Programming Photodegradability into Vinylic Polymers via Radical Ring‐Opening Polymerization
Programming Photodegradability into Vinylic Polymers via Radical Ring‐Opening Polymerization Open
Incorporation of photolabile moieties into the polymer backbone holds promise to remotely‐control polymer degradation. However, suitable synthetic avenues are limited, especially for radical polymerizations. Here we report a strategy to pr…
View article: Programming Photodegradability into Vinylic Polymers via Radical Ring‐Opening Polymerization
Programming Photodegradability into Vinylic Polymers via Radical Ring‐Opening Polymerization Open
Incorporation of photolabile moieties into the polymer backbone holds promise to remotely‐control polymer degradation. However, suitable synthetic avenues are limited, especially for radical polymerizations. Here we report a strategy to pr…
View article: OzFAD: Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome
OzFAD: Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome Open
Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acid are often masked in contemporary analysis by incomplete separation and the absence of sufficiently d…
View article: Exploring the Gas‐Phase Formation and Chemical Reactivity of Highly Reduced M<sub>8</sub>L<sub>6</sub> Coordination Cages
Exploring the Gas‐Phase Formation and Chemical Reactivity of Highly Reduced M<sub>8</sub>L<sub>6</sub> Coordination Cages Open
Coordination cages with well‐defined cavities show great promise in the field of catalysis on account of their unique combination of molecular confinement effects and transition‐metal redox chemistry. Here, three coordination cages are red…
View article: Exploring the Gas‐Phase Formation and Chemical Reactivity of Highly Reduced M<sub>8</sub>L<sub>6</sub> Coordination Cages
Exploring the Gas‐Phase Formation and Chemical Reactivity of Highly Reduced M<sub>8</sub>L<sub>6</sub> Coordination Cages Open
Coordination cages with well‐defined cavities show great promise in the field of catalysis on account of their unique combination of molecular confinement effects and transition‐metal redox chemistry. Here, three coordination cages are red…
View article: Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer Open
The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is…
View article: Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer
Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer Open
1.0 Summary Cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular fatty acids (FA) and de novo synthesis. Given that oxidation of de novo synthesised FAs for energy would result in net-energy…
View article: Actinic Wavelength Action Spectroscopy of the IO− Reaction Intermediate
Actinic Wavelength Action Spectroscopy of the IO− Reaction Intermediate Open
Iodinate anions are important in the chemistry of the atmosphere where they are implicated in ozone depletion and particle formation. The atmospheric chemistry of iodine is a complex overlay of neutral-neutral, ion-neutral and photochemica…
View article: Actinic Wavelength Action Spectroscopy of the IO− Reaction Intermediate
Actinic Wavelength Action Spectroscopy of the IO− Reaction Intermediate Open
Iodinate anions are important in the chemistry of the atmosphere where they are implicated in ozone depletion and particle formation. The atmospheric chemistry of iodine is a complex overlay of neutral-neutral, ion-neutral and photochemica…
View article: Isomer-Resolved Imaging of Prostate Cancer Tissues Reveals Specific Lipid Unsaturation Profiles Associated With Lymphocytes and Abnormal Prostate Epithelia
Isomer-Resolved Imaging of Prostate Cancer Tissues Reveals Specific Lipid Unsaturation Profiles Associated With Lymphocytes and Abnormal Prostate Epithelia Open
Prostate cancer is the fourth most common cancer worldwide with definitive diagnosis reliant on biopsy and human-graded histopathology. As with other pathologies, grading based on classical haematoxylin and eosin (H&E) staining of form…
View article: Mass Spectrometry Imaging of Lipids with Isomer Resolution Using High-Pressure Ozone-Induced Dissociation
Mass Spectrometry Imaging of Lipids with Isomer Resolution Using High-Pressure Ozone-Induced Dissociation Open
Mass spectrometry imaging (MSI) of lipids within tissues has significant potential for both biomolecular discovery and histopathological applications. Conventional MSI technologies are, however, challenged by the prevalence of phospholipid…
View article: PHOTODEPLETION SPECTROSCOPY OF IO<sup>&#8722;</sup> WITHIN THE ACTINIC RANGE
PHOTODEPLETION SPECTROSCOPY OF IO<sup>−</sup> WITHIN THE ACTINIC RANGE Open
Iodine oxides (I$_{x}$O$_{y}$) are atmospherically important due to their high reactivity with ozone. The I$^{-}$ anion has been detected in the atmosphere, along with IO$_{2}$$^{-}$ and IO$_{3}$$^{-}$ however, IO$^{-}$ is yet to be direct…
View article: Apocryphal FADS2 activity promotes fatty acid diversification in cancer
Apocryphal FADS2 activity promotes fatty acid diversification in cancer Open
View article: Next-generation derivatization reagents optimized for enhanced product ion formation in photodissociation-mass spectrometry of fatty acids
Next-generation derivatization reagents optimized for enhanced product ion formation in photodissociation-mass spectrometry of fatty acids Open
Next-generation derivatives for photodissociation-mass spectrometry for fatty acids generating photoproduct yields of up to 97% at 266 nm.
View article: Reactivity Trends in the Gas Phase Addition of Acetylene to N-protonated Aryl Radical Cations
Reactivity Trends in the Gas Phase Addition of Acetylene to N-protonated Aryl Radical Cations Open
A key step in gas-phase polycyclic aromatic hydrocarbon (PAH) formation involves the addition of acetylene (or other alkyne) to σ-type aromatic radicals, with successive additions yielding more complex PAHs. A similar process can happen…