Beth D. Darnall
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View article: From randomized controlled trial to real world clinical evidence: effectiveness and engagement of in-home virtual reality pain treatment for chronic pain in older adults
From randomized controlled trial to real world clinical evidence: effectiveness and engagement of in-home virtual reality pain treatment for chronic pain in older adults Open
Chronic lower back pain prevalence is greatest among older adults. Older adults (65+) often have multiple comorbidities and are more likely to have high-impact chronic pain that significantly impacts daily activities and function. Owing to…
View article: Digital twin learning health systems and multimodal biomarkers transform pain care
Digital twin learning health systems and multimodal biomarkers transform pain care Open
Despite scientific advances, pain care remains fragmented, inaccessible, and imprecise. We propose a future in which Digital Twin Learning Health Systems (DT-LHS) transform pain management by integrating multimodal biomarkers, real-time da…
View article: Cannabis
Cannabis Open
Objective Cannabis use is expanding rapidly, and a guideline is needed to address workplace issues. Methods The ACOEM Guidelines methodology was used to develop an evidence-based guideline. Results There is some evidence suggesting potenti…
View article: Changes in Pain Catastrophizing and Related Outcomes Following a Single-Session Empowered Relief Intervention Delivered by Physical Therapists in Workers with Low Back Pain: A Pilot Study
Changes in Pain Catastrophizing and Related Outcomes Following a Single-Session Empowered Relief Intervention Delivered by Physical Therapists in Workers with Low Back Pain: A Pilot Study Open
Empowered Relief, when delivered by physical therapists, may offer a rapid, scalable intervention to complement physical therapy and improve early outcomes in workers with low back pain. The results provide evidence to support a future ran…
View article: Key features associated with opioid misuse in chronic pain: A machine learning cross-sectional study
Key features associated with opioid misuse in chronic pain: A machine learning cross-sectional study Open
Importance Opioid misuse remains a critical public health concern, associated with increased risk of overdose, psychiatric comorbidity, and societal costs. While machine learning (ML) analyses have been used to identify features associated…
View article: Virtual reality-delivered skills-based therapy for chronic lower back pain: from proof-of-concept to FDA authorization to clinical implementation in-home and beyond
Virtual reality-delivered skills-based therapy for chronic lower back pain: from proof-of-concept to FDA authorization to clinical implementation in-home and beyond Open
Chronic lower back pain (cLBP) is the most prevalent pain condition globally. Pain education and cognitive behavior therapy (CBT) are one of many recommended front-line treatments, but access is poor due to barriers such as few trained and…
View article: Initial Feasibility and Acceptability of Cancer Pain 101: An Interdisciplinary, Single‐Session, Telehealth Intervention for Patients With Cancer‐Related Pain
Initial Feasibility and Acceptability of Cancer Pain 101: An Interdisciplinary, Single‐Session, Telehealth Intervention for Patients With Cancer‐Related Pain Open
Introduction Patients with cancer have limited access to comprehensive pain treatment. We developed a 90‐min, single‐session, telehealth, interdisciplinary intervention that combines cancer‐specific medical education and behavioral pain tr…
View article: Differential treatment response to virtual reality in high-impact chronic pain: secondary analysis of a randomized trial
Differential treatment response to virtual reality in high-impact chronic pain: secondary analysis of a randomized trial Open
High-impact chronic pain (HICP) affects 8.5% of the population and is associated with higher healthcare utilization and costs. Sparse data exist on pain treatment response differences between HICP vs. lower-impact chronic pain (LICP). We c…
View article: Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids
Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids Open
Background Patients with chronic pain on long-term opioid therapy often face barriers to accessing effective nonpharmacological treatments, including the burden of multiple sessions, lack of trained clinicians, and travel time. Empowered R…
View article: Upskilling pain relief after surgery: a scoping review of perioperative behavioral intervention efficacy and practical considerations for implementation
Upskilling pain relief after surgery: a scoping review of perioperative behavioral intervention efficacy and practical considerations for implementation Open
Perioperative skills-based interventions may support non-pharmacological management of pain and opioid reduction after surgery. Such interventions may target and enhance predictors for surgical recovery and possibly reduce chronic postsurg…
View article: The problem of pain in systemic lupus erythematosus: A comprehensive analysis of pain distribution using the CHOIR body map and PROMIS measures
The problem of pain in systemic lupus erythematosus: A comprehensive analysis of pain distribution using the CHOIR body map and PROMIS measures Open
Background Our study investigates the associations between pain distribution, biopsychosocial factors, and Patient-Reported Outcomes Measurement Information System (PROMIS) measures in patients with systemic lupus erythematosus (SLE). Empl…
View article: Twelve-month results for a randomized sham-controlled effectiveness trial of an in-home skills-based virtual reality program for chronic low back pain
Twelve-month results for a randomized sham-controlled effectiveness trial of an in-home skills-based virtual reality program for chronic low back pain Open
Introduction: Low-risk, accessible, and long-term effective nonpharmacologic behavioral interventions for chronic low back pain (cLBP) are needed. Pain education and cognitive behavioral therapy (CBT) are recommended first-line treatments,…
View article: Protocol for a randomised trial of a self-directed digital pain management intervention (Empowered Relief) tailored to adults with chronic pain and prescription opioid misuse/disorder: the MOBILE Relief study
Protocol for a randomised trial of a self-directed digital pain management intervention (Empowered Relief) tailored to adults with chronic pain and prescription opioid misuse/disorder: the MOBILE Relief study Open
Introduction Chronic pain increases the risk of prescription opioid misuse or opioid use disorder (OUD). Non-pharmacological treatments are needed to dually address pain and opioid risks. The purpose of the Mobile and Online-Based Interven…
View article: Feasibility of Web-Based Single-Session Empowered Relief in Patients With Chronic Pain Taking Methadone or Buprenorphine: Protocol for a Single-Arm Trial
Feasibility of Web-Based Single-Session Empowered Relief in Patients With Chronic Pain Taking Methadone or Buprenorphine: Protocol for a Single-Arm Trial Open
Background Chronic pain affects tens of millions of US adults and continues to rise in prevalence. Nonpharmacologic behavioral pain treatments are greatly needed and yet are often inaccessible, particularly in settings where medication pre…
View article: Innovative Approaches for Developing Digital Behavioral Health Interventions: A Case Study for Navigating Challenges in Technology, Skills, and Resources (Preprint)
Innovative Approaches for Developing Digital Behavioral Health Interventions: A Case Study for Navigating Challenges in Technology, Skills, and Resources (Preprint) Open
UNSTRUCTURED Digital behavioral health interventions provide unprecedented opportunities to increase access to evidence-based treatment but are time-consuming and expensive to develop. Research has identified lack of technical knowledge a…
View article: Sociodemographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for an In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial
Sociodemographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for an In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial Open
Health care inequities are well-established in chronic pain care. Immersive digital therapeutics may transcend such barriers by offering in-home access with no Wi-Fi connectivity required, and easy to use, gaze-based navigation, and therap…
View article: A digital health intervention to support patients with chronic pain during prescription opioid tapering: a pilot randomised controlled trial
A digital health intervention to support patients with chronic pain during prescription opioid tapering: a pilot randomised controlled trial Open
Introduction: Recent changes in opioid prescribing guidelines have led to an increasing number of patients with chronic pain being recommended to taper. However, opioid tapering can be challenging, and many patients require support. Object…
View article: Empowered Relief, cognitive behavioral therapy, and health education for people with chronic pain: a comparison of outcomes at 6-month Follow-up for a randomized controlled trial
Empowered Relief, cognitive behavioral therapy, and health education for people with chronic pain: a comparison of outcomes at 6-month Follow-up for a randomized controlled trial Open
Introduction: We previously conducted a 3-arm randomized trial (263 adults with chronic low back pain) which compared group-based (1) single-session pain relief skills intervention (Empowered Relief; ER); (2) 8-session cognitive behavioral…
View article: Pain education research: Advances, innovations, and challenges
Pain education research: Advances, innovations, and challenges Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Using Lean Six Sigma Methods to Develop an Efficient and Sustainable Interdisciplinary Team Program for Chronic Pain in a VA: PREVAIL Interdisciplinary Team Track
Using Lean Six Sigma Methods to Develop an Efficient and Sustainable Interdisciplinary Team Program for Chronic Pain in a VA: PREVAIL Interdisciplinary Team Track Open
Background Chronic pain is highly prevalent in US military Veterans, and pain interdisciplinary teams (IDTs) are the gold standard in pain care. There is no standard or guidance for how best to develop and implement pain interdisciplinary …
View article: Perspective: The Promise of Virtual Reality as an Immersive Therapeutic
Perspective: The Promise of Virtual Reality as an Immersive Therapeutic Open
In this perspective, we discuss the promise of virtual reality (VR) as an immersive therapeutic (ITx) delivery device. We review the neurobiology of learning and show that VR broadly engages multiple learning systems in the brain in synchr…