Beth E. Davis
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View article: Promoting Optimal Development: Screening for Mental Health, Emotional, and Behavioral Problems: Clinical Report
Promoting Optimal Development: Screening for Mental Health, Emotional, and Behavioral Problems: Clinical Report Open
Rates of mental health, emotional, and behavioral (MEB) problems in the United States continue to rise, with current estimates of 13% to 20% of children having an MEB disorder and an additional 19% with problems causing impairment or distr…
View article: Family partnerships to support equity and cultural humility in pediatric intervention research
Family partnerships to support equity and cultural humility in pediatric intervention research Open
Objective Family partnerships in community-engaged research (CEnR) can promote family-centered, equitable interventions. This paper describes the process (meeting frequency, content) of a collaborative research family partnership and relat…
View article: 1015 Understanding Contributors to Early Childhood Sleep Intervention Response: A Mixed Methods Study
1015 Understanding Contributors to Early Childhood Sleep Intervention Response: A Mixed Methods Study Open
Introduction This mixed-methods study sought to identify contributors to caregiver-reported child sleep improvements after receiving Sleep Well!, a behavioral sleep intervention for 1-5-year-olds, by examining (1) quantitative data from in…
View article: 0980 Discrepancies in Caregiver-Reported and Laboratory-Assessed Early Childhood Sleep Problems
0980 Discrepancies in Caregiver-Reported and Laboratory-Assessed Early Childhood Sleep Problems Open
Introduction Sleep disordered breathing (SDB) and insufficient sleep are common in early childhood and linked to neurobehavioral functioning, highlighting the importance of screening for these sleep problems. However, few studies have exam…
View article: Socioecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes: protocol for the sleep in preschoolers cross-sectional study
Socioecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes: protocol for the sleep in preschoolers cross-sectional study Open
Introduction Sleep deficiencies, such as sleep disordered breathing (SDB) and insufficient sleep, are linked to adverse health outcomes. These sleep deficiencies are more common in racial and ethnic minoritised children and have significan…
View article: To stop or not to stop an asthma biologic, that is the question
To stop or not to stop an asthma biologic, that is the question Open
During a time when anti-asthma biologics are readily accessible, the article by Brightling et al1 in the current issue provides additional much needed evidence to discuss with patients with severe asthma when the inevitable question arises…
View article: Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial
Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial Open
Background Benralizumab induces rapid and near-complete depletion of eosinophils from blood and lung tissue. We investigated whether benralizumab could attenuate the allergen-induced late asthmatic response (LAR) in participants with aller…
View article: Integration of Family Navigation into ECHO Autism for Pediatric Primary Care in Underserved Communities
Integration of Family Navigation into ECHO Autism for Pediatric Primary Care in Underserved Communities Open
Children with autism from underserved communities face complex system-, provider-, and family-level barriers to accessing timely diagnosis and early intervention. The current study evaluated the preliminary effects and feasibility of a new…
View article: Respiratory System Dynamics
Respiratory System Dynamics Open
While static mechanical forces govern resting lung volumes, dynamic forces determine tidal breathing, airflow, and changes in airflow and lung volume during normal and abnormal breathing. This section will examine the mechanisms, measureme…
View article: Primary Care Framework to Monitor Preterm Infants for Neurodevelopmental Outcomes in Early Childhood
Primary Care Framework to Monitor Preterm Infants for Neurodevelopmental Outcomes in Early Childhood Open
To support decision-making in the primary care medical home, this clinical report links preterm birth and perinatal complications to early childhood developmental disability risks. It consolidates extensive contemporary outcome research fr…
View article: 0020 Associations between bedtime and waketime variability and sleep outcomes in autistic children
0020 Associations between bedtime and waketime variability and sleep outcomes in autistic children Open
Introduction Up to 80% of autistic children experience sleep disturbances. Sleep hygiene guidelines advise patients to maintain consistent bedtimes and waketimes for the purpose of regulating one’s circadian rhythm. However, the relationsh…
View article: 0122 Sleep Moderates Arousal and Executive Functioning in Autistic Children
0122 Sleep Moderates Arousal and Executive Functioning in Autistic Children Open
Introduction Arousal dysregulation (over- or under-arousal) and executive functioning (EF) difficulties are positively correlated and often experienced by autistic children. Arousal and task performance (e.g., EF) are connected, such that …
View article: The ABCs and DEGs (Differentially Expressed Genes) of Airway Hyperresponsiveness
The ABCs and DEGs (Differentially Expressed Genes) of Airway Hyperresponsiveness Open
"The “ABCs” of DEGs in Airway Hyperresponsiveness." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
View article: Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma
Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma Open
Background Thymic stromal lymphopoietin (TSLP) is a key upstream regulator driving allergic inflammatory responses. We evaluated the efficacy and safety of ecleralimab, a potent inhaled neutralising antibody fragment against human TSLP, us…
View article: Allergen bronchoprovocation: correlation between FEV1 maximal percent fall and area under the FEV1 curve and impact of allergen on recovery
Allergen bronchoprovocation: correlation between FEV1 maximal percent fall and area under the FEV1 curve and impact of allergen on recovery Open
Background House dust mite (HDM) induces greater responses than other allergens during allergen bronchoprovocation (ABP) testing. The two standardized methods for reporting results of ABP tests are the maximal percent fall in forced expira…
View article: Sounding the alarmins—The role of alarmin cytokines in asthma
Sounding the alarmins—The role of alarmin cytokines in asthma Open
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells expose…
View article: Allergen bronchoprovocation: Correlation between FEV1 maximal percent fall and area under the FEV1 curve and impact of allergen on recovery.
Allergen bronchoprovocation: Correlation between FEV1 maximal percent fall and area under the FEV1 curve and impact of allergen on recovery. Open
Background House dust mite (HDM) induces greater responses than other allergens during allergen bronchoprovocation (ABP) testing. The two standardized methods for reporting results of ABP tests are the maximal percent fall in forced expira…
View article: Muscarinic Receptor Antagonism and Allergen Induced Airway Responses in Allergic Asthma: A Scoping Review
Muscarinic Receptor Antagonism and Allergen Induced Airway Responses in Allergic Asthma: A Scoping Review Open
Purpose The purpose of this scoping review was to identify existing clinical and basic science knowledge surrounding the effect of muscarinic receptor antagonism on allergen-induced airway responses to inform future clinical research in th…
View article: 0485 Verbal Hostility Moderates Parental and Child Sleep Onset Latency in Children with Autism Spectrum Disorder
0485 Verbal Hostility Moderates Parental and Child Sleep Onset Latency in Children with Autism Spectrum Disorder Open
Introduction Research indicates parent and child sleep onset latency (SOL) are positively correlated. In addition, parents who have difficulty sleeping may be more tired and report using negative parenting behaviors, such as verbal hostili…
View article: 0611 Intraindividual Variability in Subjective Sleep and Average Fatigue in Parents of Children on the Autism Spectrum
0611 Intraindividual Variability in Subjective Sleep and Average Fatigue in Parents of Children on the Autism Spectrum Open
Introduction Fatigue is related to various adverse health outcomes. Mean levels of some common sleep variables, such as total sleep time (TST), sleep onset latency (SOL), and wake after sleep onset (WASO), have been associated with fatigue…
View article: Allergen provocation tests in respiratory research: building on 50 years of experience
Allergen provocation tests in respiratory research: building on 50 years of experience Open
The allergen provocation test is an established model of allergic airway diseases, including asthma and allergic rhinitis, allowing the study of allergen-induced changes in respiratory physiology and inflammatory mechanisms in sensitised i…
View article: Protocol for targeting insomnia in school-aged children with autism spectrum disorder without intellectual disability: a randomised control trial
Protocol for targeting insomnia in school-aged children with autism spectrum disorder without intellectual disability: a randomised control trial Open
Introduction Insomnia affects up to 80% of children with autism spectrum disorder (ASD). Negative consequences of insomnia in ASD include decreased quality of life (QOL), impaired learning and cognition, increased stereotypic and challengi…
View article: Promoting Healthy Sexuality for Children and Adolescents With Disabilities
Promoting Healthy Sexuality for Children and Adolescents With Disabilities Open
This clinical report updates a 2006 report from the American Academy of Pediatrics titled “Sexuality of Children and Adolescents With Developmental Disabilities.” The development of a healthy sexuality best occurs through appropriate educa…
View article: 579 Child Sleep Onset Latency Mediates Parental Depression and Non-Compliance in Children with Autism Spectrum Disorder
579 Child Sleep Onset Latency Mediates Parental Depression and Non-Compliance in Children with Autism Spectrum Disorder Open
Introduction Parents who have been diagnosed with depression often report that their children are not compliant and have difficulty falling asleep. Parents with depression are less likely to be consistent or enforce bedtimes resulting in t…
View article: Direct and indirect bronchoprovocation tests in dose‐response studies of inhaled corticosteroids: Past, present, and future directions
Direct and indirect bronchoprovocation tests in dose‐response studies of inhaled corticosteroids: Past, present, and future directions Open
Inhaled corticosteroids (ICS) are a mainstay of treatment in eosinophilic asthma. Many studies have explored the dose‐response effect of different formulations of ICS through direct or indirect bronchoprovocation testing. Such studies are …
View article: Children With Intellectual and Developmental Disabilities as Organ Transplantation Recipients
Children With Intellectual and Developmental Disabilities as Organ Transplantation Recipients Open
The demand for transplantable solid organs far exceeds the supply of deceased donor organs. Patient selection criteria are determined by individual transplant programs; given the scarcity of solid organs for transplant, allocation to those…
View article: Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation
Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation Open
Background Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.). However, data surr…