Beth J. Allison
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View article: Caffeine-associated reduction in patent ductus arteriosus is mediated in part by adenosine receptor antagonism
Caffeine-associated reduction in patent ductus arteriosus is mediated in part by adenosine receptor antagonism Open
Caffeine is a respiratory stimulant and one of the most commonly prescribed drugs in the NICU. Primarily used to reduce apnea of prematurity, additional therapeutic benefits have been noted, including decreasing the incidence of patent duc…
View article: Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates
Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates Open
The cardiopulmonary transition at birth is a critical physiological process requiring coordinated cardiovascular adaptation to meet the increased circulatory demands of extrauterine life. This transition may be compromised in infants affec…
View article: Persistent inflammation and white matter damage in the preterm brain: Insights from a novel ovine model of chronic inflammation
Persistent inflammation and white matter damage in the preterm brain: Insights from a novel ovine model of chronic inflammation Open
We demonstrated that in a large animal model of inflammation-induced intrauterine preterm brain injury, long-term persistent inflammation occurs, along with significant white matter injury, including loss of oligodendrocytes and reduced my…
View article: Ibuprofen Does Not Prevent Inhibition of Fetal Breathing Movements Caused by Intrauterine Inflammation in Fetal Sheep
Ibuprofen Does Not Prevent Inhibition of Fetal Breathing Movements Caused by Intrauterine Inflammation in Fetal Sheep Open
Antenatal inflammation/infection is a major cause of neonatal apnoea and hypoventilation. Prostaglandin E2 (PGE2) is a key inflammatory mediator associated with depression of fetal and neonatal breathing. We aimed to determine whether ante…
View article: Perinatal Asphyxia Alters Physiological Responses and <i>Ex Vivo</i> Cardiovascular Function of Preterm Growth-Restricted Lambs
Perinatal Asphyxia Alters Physiological Responses and <i>Ex Vivo</i> Cardiovascular Function of Preterm Growth-Restricted Lambs Open
Introduction Fetal growth restriction (FGR) arises from chronic hypoxia and increases the risk of cardiovascular dysfunction following perinatal asphyxia, although the underlying mechanisms are unknown. We investigated whether FGR lambs ha…
View article: Pathogenesis of Preterm Intraventricular Haemorrhage
Pathogenesis of Preterm Intraventricular Haemorrhage Open
Background Intraventricular haemorrhage (IVH) is the primary neuropathology in infants born very preterm. IVH describes bleeding into the ventricular space of the newborn brain, originating from the germinal matrix, termed germinal matrix …
View article: Antenatal Vitamin C differentially affects lung development in normally grown and growth restricted sheep
Antenatal Vitamin C differentially affects lung development in normally grown and growth restricted sheep Open
Background Chronic hypoxemia is a common cause of fetal growth restriction and can have significant effects on the developing fetal lung. Maternal antioxidant treatment in hypoxic pregnancy protects against offspring cardiovascular dysfunc…
View article: The interplay between birth weight and intraventricular hemorrhage in very preterm neonates—a retrospective cohort study
The interplay between birth weight and intraventricular hemorrhage in very preterm neonates—a retrospective cohort study Open
This large retrospective cohort study identified that in very preterm infants born with a median gestational age at birth of 29 weeks and who survive to the neonatal unit, the presence of SGA or suspected FGR is associated with a reduced r…
View article: Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia
Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia Open
The mechanisms that drive placental dysfunction in pregnancies complicated by hypoxia and fetal growth restriction remain poorly understood. Changes to mitochondrial respiration contribute to cellular dysfunction in conditions of hypoxia a…
View article: Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood
Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood Open
Introduction Chronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of …
View article: Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function
Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function Open
The last pregnancy trimester is critical for fetal brain development but is a vulnerable period if the pregnancy is compromised by fetal growth restriction (FGR). The impact of FGR on the maturational development of neuronal morphology is …
View article: The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review
The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review Open
Fetal growth restriction (FGR) increases the risk of cardiovascular disease. There are currently no treatment options available; however, antioxidants have shown potential to improve cardiovascular deficits associated with FGR. This system…
View article: Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health
Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health Open
The negative impact of cigarettes on the health of the developing fetus was first recognized by Simpson (1957). Since then, our understanding of the adverse impacts of smoking on fetal health has grown to include fetal growth restriction a…
View article: The synergistic effects of mechanical ventilation and intrauterine inflammation on cerebral inflammation in preterm fetal sheep
The synergistic effects of mechanical ventilation and intrauterine inflammation on cerebral inflammation in preterm fetal sheep Open
Background Intrauterine inflammation and the requirement for mechanical ventilation independently increase the risk of perinatal brain injury and adverse neurodevelopmental outcomes. We aimed to investigate the effects of mechanical ventil…
View article: Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis
Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis Open
Introduction Lung injuries, such as bronchopulmonary dysplasia (BPD), remain a major complication of preterm birth, with limited therapeutic options. One potential emerging therapy is umbilical cord blood (UCB)-derived therapy. Objectives …
View article: Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies Open
View article: Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies Open
The hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturba…
View article: Phenotype of early-onset fetal growth restriction in sheep
Phenotype of early-onset fetal growth restriction in sheep Open
Introduction Fetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to imp…
View article: A liquid chromatographic-mass spectrometric procedure for analysis of pentaerythrityl tetranitrate metabolites – Development, validation and application to ovine serum and human plasma samples
A liquid chromatographic-mass spectrometric procedure for analysis of pentaerythrityl tetranitrate metabolites – Development, validation and application to ovine serum and human plasma samples Open
Pentaerythrityl tetranitrate (PETN) is an established drug in the treatment of coronary heart disease and heart failure. It is assumed, that the vasodilative and vasoprotective effects of PETN also have a positive impact on pregnant patien…
View article: Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction
Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction Open
View article: Mechanical ventilation induces brainstem inflammation in preterm fetal sheep
Mechanical ventilation induces brainstem inflammation in preterm fetal sheep Open
Background Preterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however…
View article: Cardiovascular responses to mild perinatal asphyxia in growth-restricted preterm lambs
Cardiovascular responses to mild perinatal asphyxia in growth-restricted preterm lambs Open
Preterm growth-restricted lambs maintain carotid blood flow for longer than control lambs during asphyxia and have a lower requirement for chest compressions than control lambs during resuscitation. Preterm growth-restricted, but not contr…
View article: The medullary serotonergic centres involved in cardiorespiratory control are disrupted by fetal growth restriction
The medullary serotonergic centres involved in cardiorespiratory control are disrupted by fetal growth restriction Open
Fetal growth restriction (FGR) is associated with cardiovascular and respiratory complications after birth and beyond. Despite research showing a range of neurological changes following FGR, little is known about how FGR affects the brains…
View article: Does fetal growth restriction induce neuropathology within the developing brainstem?
Does fetal growth restriction induce neuropathology within the developing brainstem? Open
Fetal growth restriction (FGR) is a complex obstetric issue describing a fetus that does not reach its genetic growth potential. The primary cause of FGR is placental dysfunction resulting in chronic fetal hypoxaemia, which in turn causes …
View article: MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy
MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy Open
Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy i…
View article: Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs
Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs Open
Background Fetal growth restriction (FGR) is associated with deficits in the developing brain, including neurovascular unit (NVU) dysfunction. Endothelial colony forming cells (ECFC) can mediate improved vascular stability, and have demons…
View article: Combined Statin and Glucocorticoid Therapy for the Safer Treatment of Preterm Birth
Combined Statin and Glucocorticoid Therapy for the Safer Treatment of Preterm Birth Open
Background: Prematurity is strongly associated with poor respiratory function in the neonate. Rescue therapies include treatment with glucocorticoids due to their anti-inflammatory and maturational effects on the developing lung. However, …
View article: Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology
Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology Open
Congenital diaphragmatic hernia (CDH) is a major cause of severe lung hypoplasia and pulmonary hypertension in the newborn. While the pulmonary hypertension is thought to result from abnormal vascular development and arterial vasoreactivit…
View article: Myocardial perfusion and function dichotomy in growth restricted preterm infants
Myocardial perfusion and function dichotomy in growth restricted preterm infants Open
Compared to preterm appropriate for gestational age (AGA) fetuses, fetuses with fetal growth restriction (FGR) have earlier visualisation of coronary artery blood flow (CABF) but impaired cardiac function. This dichotomy remains uncharacte…
View article: Targeting vasculature to reduce fetal growth restriction associated bronchopulmonary dysplasia
Targeting vasculature to reduce fetal growth restriction associated bronchopulmonary dysplasia Open
Fetal growth restriction (FGR) affects a significant proportion of pregnancies delivered prematurely. Generally, FGR refers to birthweight <10th centile for gestational age and sex, accompanied by absent/reversed Doppler in systemic arteri…