Beth Levine
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View article: Author Correction: An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis
Author Correction: An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis Open
The original version of this Article contained an error in the Methods section, in the subsection labelled Pyrene-actin polymerization assay, which incorrectly omitted details of how data was processed.The following sentence has been added…
View article: Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2–Beclin 1 Protein–Protein Interaction
Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2–Beclin 1 Protein–Protein Interaction Open
Autophagy plays essential roles in a wide variety of physiological processes, such as cellular homeostasis, metabolism, development, differentiation, and immunity. Selective pharmacological modulation of autophagy is considered a valuable …
View article: STING controls energy stress-induced autophagy and energy metabolism via STX17
STING controls energy stress-induced autophagy and energy metabolism via STX17 Open
The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging evidence suggests that STING is important for DNA or cGAMP-induced non-canonical autophagy, which is independent of a large part of canonical aut…
View article: Enhanced autophagy in <i>Becn1<sup>F121A/F121A</sup></i> knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction
Enhanced autophagy in <i>Becn1<sup>F121A/F121A</sup></i> knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction Open
Macroautophagy/autophagy is emerging as a major pathway that regulates both aging and stem cell function. Previous studies have demonstrated a positive correlation of autophagy with longevity; however, these studies did not directly addres…
View article: An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system
An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system Open
The addictive effects of cocaine are regulated by an autophagy protein and can be prevented by autophagy inhibitors.
View article: Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin
Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin Open
Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in elevated IOP are the most common genetic causes of POAG. We have previous…
View article: Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin Open
Significance Beclin 1, an essential autophagy protein, is important for tumor suppression in mice, as well as in human breast and ovarian cancers. However, it is not well understood how Beclin 1 acts as a tumor suppressor. By performing a …
View article: Enhanced autophagy in <i>Becn1<sup>F121A/F121A</sup></i> knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction
Enhanced autophagy in <i>Becn1<sup>F121A/F121A</sup></i> knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction Open
Macroautophagy/autophagy is emerging as a major pathway that regulates both aging and stem cell function. Previous studies have demonstrated a positive correlation of autophagy with longevity; however, these studies did not directly addres…
View article: GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Open
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting of PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decre…
View article: GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Open
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting of PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decre…
View article: GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Open
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting of PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decre…
View article: Quantitative Fluorescence Resonance Energy Transfer Measurements Using Fluorescence Microscopy
Quantitative Fluorescence Resonance Energy Transfer Measurements Using Fluorescence Microscopy Open
Fluorescence resonance energy transfer (FRET) is a technique used for quantifying the distance between two molecules conjugated to different fluorophores. By combining optical microscopy with FRET it is possible to obtain quantitative temp…
View article: Beclin 2 negatively regulates innate immune signaling and tumor development
Beclin 2 negatively regulates innate immune signaling and tumor development Open
Beclin 2 plays a critical role in metabolic regulation and obesity, but its functions in innate immune signaling and cancer development remain largely unknown. Here, we identified Beclin 2 as a critical negative regulator of inflammation a…
View article: The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance
The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance Open
Aging‐related organ degeneration is driven by multiple factors including the cell maintenance mechanisms of autophagy, the cytoprotective protein αKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity. To examin…
View article: GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Open
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting of PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decre…
View article: Protective Effect of SMAD‐Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice
Protective Effect of SMAD‐Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice Open
Excessive accumulation of lipids in the liver is crucial in the pathogenesis of alcoholic steatohepatitis and may be partly mediated by impaired degradation of lipid droplets by autophagy. The E3 ubiquitin ligase SMAD‐specific E3 ubiquitin…
View article: Cell Penetration Profiling Using the Chloroalkane Penetration Assay
Cell Penetration Profiling Using the Chloroalkane Penetration Assay Open
Biotherapeutics are a promising class of molecules in drug discovery, but they are often limited to extracellular targets due to their poor cell penetration. High-throughput cell penetration assays are required for the optimization of biot…
View article: 19 Autophagy induction as a new therapy for HER2+ breast tumorigenesis
19 Autophagy induction as a new therapy for HER2+ breast tumorigenesis Open
Introduction HER2 is a receptor tyrosine kinase whose gene is amplified in ~20% human breast cancer patients. Allelic loss of the autophagy gene, beclin 1/BECN1, is associated with HER2 amplification in breast cancer; low beclin 1 mRNA ex…