Beth S. Lee
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View article: Multiscale Analysis Reveals Altered Characteristics in Femur and Mandible of Mice on a High Phosphate Diet
Multiscale Analysis Reveals Altered Characteristics in Femur and Mandible of Mice on a High Phosphate Diet Open
Excessive phosphate used as flavor enhancers and preservatives in processed foods can exacerbate cardiovascular and kidney diseases. In clinical and pre-clinical studies, chronic (over 52 weeks) high-phosphate diet (HPD) negatively affects…
View article: Multiscale characterization of jawbone treated with osteoporosis therapeutic agents
Multiscale characterization of jawbone treated with osteoporosis therapeutic agents Open
The objective of the current study was to determine whether treatments of bisphosphonate (alendronate (ALN)), parathyroid hormone (PTH), and their combination have an effect on the jawbone in estrogen deficient rats. Six female rats (4-mon…
View article: Discoidin Domain Receptor 1 impacts bone microarchitecture with aging in female mice
Discoidin Domain Receptor 1 impacts bone microarchitecture with aging in female mice Open
Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase that binds to and is activated by collagen(s), including collagen type I. Ddr1 deletion in osteoblasts and chondrocytes has previously demonstrated the importance of this rec…
View article: The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli Open
Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in a…
View article: Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes Open
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mitochondria from female hea…
View article: Myosin X Regulates Sealing Zone Patterning in Osteoclasts through Linkage of Podosomes and Microtubules
Myosin X Regulates Sealing Zone Patterning in Osteoclasts through Linkage of Podosomes and Microtubules Open
Osteoclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and non-bone substrates. On glass, osteoclasts generate podosomes, foot-like processes containing a core of F-actin and regulatory proteins …
View article: Myosins in Osteoclast Formation and Function
Myosins in Osteoclast Formation and Function Open
Skeletal quantity and quality are determined by processes of bone modeling and remodeling, which are undertaken by cells that build and resorb bone as they respond to mechanical, hormonal, and other external and internal signals. As the so…
View article: Regulation of Osteoclast Differentiation by Myosin X
Regulation of Osteoclast Differentiation by Myosin X Open
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known. MYO10, an unconventional myosin, has previous…
View article: The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF-1
The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF-1 Open
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some …