Beth Temple
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View article: Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam Open
The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- and middle-income countries. While several studies have assessed their immunogenicity,…
View article: Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam Open
The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- and middle-income countries. While several studies have assessed their immunogenicity,…
View article: Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis
Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis Open
Background Vaccination of infants with pneumococcal conjugate vaccines is recommended by the World Health Organization. Evidence is mixed regarding the differences in immunogenicity and efficacy of the different pneumococcal vaccines. Obje…
View article: Impact of COVID-19 Nonpharmaceutical Interventions on Pneumococcal Carriage Prevalence and Density in Vietnam
Impact of COVID-19 Nonpharmaceutical Interventions on Pneumococcal Carriage Prevalence and Density in Vietnam Open
The pneumococcus is a major cause of mortality globally. Implementation of NPIs during the COVID-19 pandemic led to reductions in invasive pneumococcal disease in many countries.
View article: Immunogenicity and seroefficacy of pneumococcal conjugate vaccines – a systematic review and network meta-analysis
Immunogenicity and seroefficacy of pneumococcal conjugate vaccines – a systematic review and network meta-analysis Open
Background Vaccination of infants with pneumococcal conjugate vaccines (PCV) is recommended by the World Health Organisation. Evidence is mixed regarding the differences in immunogenicity and efficacy of the different pneumococcal vaccines…
View article: Impact of COVID-19 non-pharmaceutical interventions on pneumococcal carriage prevalence and density in Vietnam
Impact of COVID-19 non-pharmaceutical interventions on pneumococcal carriage prevalence and density in Vietnam Open
Non-pharmaceutical interventions (NPIs) implemented to contain SARS-CoV-2 have decreased invasive pneumococcal disease. We undertook an observational study to evaluate the impact of NPIs on pneumococcal carriage and density, drivers of tra…
View article: Simplified 0+1 and 1+1 pneumococcal vaccine schedules in Ho Chi Minh City, Vietnam: protocol for a randomised controlled trial
Simplified 0+1 and 1+1 pneumococcal vaccine schedules in Ho Chi Minh City, Vietnam: protocol for a randomised controlled trial Open
Introduction Reduced-dose schedules offer a more efficient and affordable way to use pneumococcal conjugate vaccines (PCVs). Such schedules rely primarily on the maintenance of herd protection. The Vietnam Pneumococcal Trial II (VPT-II) wi…
View article: Immunogenicity of alternative ten-valent pneumococcal conjugate vaccine schedules in infants in Ho Chi Minh City, Vietnam: results from a single-blind, parallel-group, open-label, randomised, controlled trial
Immunogenicity of alternative ten-valent pneumococcal conjugate vaccine schedules in infants in Ho Chi Minh City, Vietnam: results from a single-blind, parallel-group, open-label, randomised, controlled trial Open
Australian National Health and Medical Research Council, and The Bill & Melinda Gates Foundation.
View article: Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam
Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam Open
National Health and Medical Research Council of Australia, Bill & Melinda Gates Foundation.
View article: Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar G proteins
Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar G proteins Open
Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and biochemical analysis to determine the role of intradomain and interdomain motions in con…
View article: The Crystal Structure of a Self-Activating G Protein Subunit Reveals Its Distinct Mechanism of Signal Initiation
The Crystal Structure of a Self-Activating G Protein Subunit Reveals Its Distinct Mechanism of Signal Initiation Open
In animals, heterotrimeric guanine nucleotide–binding protein (G protein) signaling is initiated by G protein–coupled receptors (GPCRs), which activate G protein α subunits; however, the plant Arabidopsis thaliana lacks canonical GPCRs, an…
View article: G 12 Structural Determinants of Hsp90 Interaction Are Necessary for Serum Response Element-Mediated Transcriptional Activation
G 12 Structural Determinants of Hsp90 Interaction Are Necessary for Serum Response Element-Mediated Transcriptional Activation Open
The G12/13 class of heterotrimeric G proteins, comprising the
View article: Immunogenicity and reactogenicity of ten-valent versus 13-valent pneumococcal conjugate vaccines among infants in Ho Chi Minh City, Vietnam: a randomised controlled trial
Immunogenicity and reactogenicity of ten-valent versus 13-valent pneumococcal conjugate vaccines among infants in Ho Chi Minh City, Vietnam: a randomised controlled trial Open
National Health and Medical Research Council of Australia, and Bill & Melinda Gates Foundation.
View article: Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial
Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial Open
Introduction WHO recommends the use of pneumococcal conjugate vaccine (PCV) as a priority. However, there are many countries yet to introduce PCV, especially in Asia. This trial aims to evaluate different PCV schedules and to provide a hea…