Bethan Dalton
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Cytokine concentrations in people with eating disorders: A comprehensive updated systematic review and meta-analysis Open
Background: Prior research has found altered levels of cytokines in people with eating disorders (EDs). This study is an update of a previous meta-analysis, including longitudinal analyses and machine learning heterogeneity analyses (MetaF…
A comprehensive updated cross-sectional and longitudinal meta-analysis of cytokines in eating disorders Open
Background Prior research has found altered levels of immune signalling proteins, such as cytokines, in people with eating disorders (EDs). This study is an update of a previously published meta-analysis. Methods This systematic review and…
Metabolic Signalling Peptides and Their Relation to Clinical and Demographic Characteristics in Acute and Recovered Females with Anorexia Nervosa Open
Background/Objectives: Recent research has established that metabolic factors may increase the vulnerability to develop anorexia nervosa (AN). The aim of this study was to explore the serum concentrations of leptin, insulin-like growth fac…
View article: Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT
Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT Open
Background A substantial proportion of anorexia nervosa patients require intensive treatments, commonly inpatient or day-patient treatment. The relative merits of these treatments for adults with anorexia nervosa are unknown. Therefore, a …
Exploring the relationship between proactive inhibition and restrictive eating behaviours in severe and enduring anorexia nervosa (SE-AN) Open
Background There is a need for improved understanding of why 20–30% of individuals with anorexia nervosa (AN) develop a severe and enduring form of illness (SE-AN). Previously, we reported differences in proactive inhibition (a pre-emptive…
Exploring Alcohol-Related Behaviours in an Adult Sample with Anorexia Nervosa and Those in Recovery Open
While individuals with Bulimia Nervosa (BN) and Binge Eating Disorder (BED) often present with a higher rate of Alcohol Use Disorder (AUD) than the general population, it is unclear whether this extends to AN. This cross-sectional study ex…
View article: Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: findings from a service evaluation
Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: findings from a service evaluation Open
Background: Timely intervention is beneficial to the effectiveness of eating disorder (ED) treatment, but limited capacity within ED services means that these disorders are often not treated with sufficient speed. This service evaluation e…
Autopsy of a failed trial part 2: Outcomes, challenges, and lessons learnt from the DAISIES trial Open
Objective The relative merits of inpatient or day‐treatment for adults with anorexia nervosa (AN) are unknown. The DAISIES trial aimed to establish the non‐inferiority of a stepped‐care day patient treatment (DPT) approach versus inpatient…
View article: Autopsy of a failed trial part 1: A qualitative investigation of clinician's views on and experiences of the implementation of the DAISIES trial in UK‐based intensive eating disorder services
Autopsy of a failed trial part 1: A qualitative investigation of clinician's views on and experiences of the implementation of the DAISIES trial in UK‐based intensive eating disorder services Open
Objective The DAISIES trial, comparing inpatient and stepped‐care day patient treatment for adults with severe anorexia nervosa was prematurely terminated in March 2022 due to poor recruitment. This qualitative study seeks to understand th…
View article: Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: Findings from a service evaluation conducted during the COVID-19 pandemic
Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: Findings from a service evaluation conducted during the COVID-19 pandemic Open
Background: Timely intervention is beneficial to the effectiveness of eating disorder (ED) treatment, but limited capacity within ED services means that these disorders are often not treated with sufficient speed. This service evaluation e…
Short communication: Serum levels of brain-derived neurotrophic factor and association with pro-inflammatory cytokines in acute and recovered anorexia nervosa Open
Brain-derived neurotrophic factor (BDNF) is a neuroprotective molecule known to be involved in neuroplasticity, learning and memory. Additionally, it may mitigate the effects of inflammation on the brain. There is inconclusive evidence as …
‘My dad was like “it's your brain, what are you doing?”’: Participant experiences of repetitive transcranial magnetic stimulation treatment in severe enduring anorexia nervosa Open
Objective Repetitive transcranial magnetic stimulation (rTMS) is a promising emerging treatment for anorexia nervosa (AN). However, to date, patients' views and experiences of this treatment have not been fully explored. To assess these, w…
Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa Open
Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient i…
Reduced MIP-1β as a Trait Marker and Reduced IL-7 and IL-12 as State Markers of Anorexia Nervosa Open
Alterations in certain inflammatory markers have been found in individuals with anorexia nervosa (AN). However, their relation to clinical characteristics has not been extensively explored, nor is it clear whether they are trait or state f…
A preliminary exploration of the effect of concurrent antidepressant medication on responses to high-frequency repetitive transcranial magnetic stimulation (rTMS) in severe, enduring anorexia nervosa Open
Background Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment option for people with severe, enduring anorexia nervosa (SE-AN). As depression is often comorbid with AN, antidepressant medication is commonly prescr…
Cytokines and Water Distribution in Anorexia Nervosa Open
In patients with anorexia nervosa (AN), decreased intracellular (ICW), extracellular (ECW), and total body water (TBW) as well as changes in serum cytokine concentrations have been reported. In this exploratory study, we measured body comp…
Patient Preferences for Antipsychotic Drug Side Effects: A Discrete Choice Experiment Open
Background Development of pharmaceutical interventions for schizophrenia emphasizes clinical efficacy and subsequent effectiveness and cost-effectiveness. However, given the many side effects of antipsychotic medication, it is important to…
“Now It's Just Old Habits and Misery”–Understanding the Impact of the Covid-19 Pandemic on People With Current or Life-Time Eating Disorders: A Qualitative Study Open
Background: Many aspects of the Covid-19 pandemic may make living with or recovery from an eating disorder (ED) particularly challenging. Understanding the processes which underlie the psychological and behavioral responses of people with …
Effects of IL-6 Signaling Pathway Inhibition on Weight and BMI: A Systematic Review and Meta-Analysis Open
Inhibitors of the IL-6 signaling pathway, such as tocilizumab, are frequently administered for the treatment of immune diseases, e.g., rheumatoid arthritis and multicentric Castleman’s disease. The aim of this systematic review and meta-an…
Repetitive transcranial magnetic stimulation treatment in severe, enduring anorexia nervosa: An open longer‐term follow‐up Open
Objective This study assessed longer‐term outcomes from a randomised controlled feasibility trial of 20 sessions of real versus sham high‐frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cor…
The effect of repetitive transcranial magnetic stimulation on food choice‐related self‐control in patients with severe, enduring anorexia nervosa Open
Objective Individuals with anorexia nervosa (AN) pursue low‐fat, low‐calorie diets even when in a state of emaciation. These maladaptive food choices may involve fronto‐limbic circuitry associated with cognitive control, habit, and reward.…
PHOSPHATIDYLCHOLINE CONTAINING LONG CHAIN OMEGA-3 FATTY ACIDS: A TREATMENT ADJUNCT FOR PATIENTS WITH ANOREXIA NERVOSA? Open
The combination of a choline-containing molecule with an ω-3 LCPUFA may be clinically effective and well tolerated. This idea is supported by the current literature on the role of inflammation, the microbiome, the gut-brain-axis, hormonal,…
Impact of TNF-α Inhibitors on Body Weight and BMI: A Systematic Review and Meta-Analysis Open
OBJECTIVE: The aim of this systematic review and meta-analysis of longitudinal studies was to ascertain to effects of TNF-α inhibitor therapy on body weight and BMI. METHODS: Three databases (PubMed, OVID, and EMBASE) were systematically s…
Cytokine Research in Depression: Principles, Challenges, and Open Questions Open
Cytokines have been implicated in the pathology of depression. Currently, the evidence is based on cross-sectional studies and meta-analytic research comparing blood concentrations of T helper type 1 (TH1), T helper type 2 (TH2), pro-infla…