Bethany E. Griffiths
YOU?
Author Swipe
Multi-omics data integration towards sustainable bovine production, health and welfare: the case of painful foot lesions Open
Claw horn disruption lesions (CHDL) are painful non-infectious foot lesions with significant animal welfare and socioeconomic impacts on the dairy industry. Lameness caused by CHDL is the main cause of involuntary culling, considerably red…
Genome-wide association studies of dairy cattle resistance to digital dermatitis recorded at four distinct lactation stages Open
Digital dermatitis (DD) is an endemic infectious hoof disease causing lameness in dairy cattle. The aim of the present study was to investigate the genetic profile of DD development using phenotypic and genotypic data on 2192 Holstein cows…
Evaluation of a fully automated 2-dimensional imaging system for real-time cattle lameness detection using machine learning Open
Early detection and prompt treatment of lame cows are crucial for proactive lameness management. This study aimed to evaluate a fully automated 2-dimensional imaging system for real-time lameness detection using artificial intelligence. Da…
A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle Open
Key factors such as stage of lactation, parity, and body fat reserves have been associated with the digital cushion thickness (DCT), however, there are discrepancies between the results of previously published studies. The objective of thi…
Progression of the faecal microbiome in preweaning dairy calves that develop cryptosporidiosis Open
Background Cryptosporidiosis is a diarrheal disease that commonly affects calves under 6-weeks-old. The causative agent, Cryptosporidium parvum, has been associated with the abundance of specific taxa in the faecal microbiome during active…
Association between a genetic index for digital dermatitis resistance and the presence of digital dermatitis, heel horn erosion, and interdigital hyperplasia in Holstein cows Open
Digital dermatitis (DD) is a polybacterial disease endemic to most UK dairy farms. It poses a major financial and welfare threat and is characterized by high incidence and recurrence rates. We aimed to investigate the association between t…
Identification of methylation markers for age and Bovine Respiratory Disease in dairy cattle Open
Methylation profiles of animals is known to differ by age and disease status. Bovine respiratory disease (BRD), a complex infectious disease, primarily affects calves and has significant impact on animal welfare and the cattle industry, pr…
Development and validation of a fully automated 2-dimensional imaging system generating body condition scores for dairy cows using machine learning Open
Monitoring body condition score (BCS) is a useful management tool to estimate the energy reserves of an individual cow or a group of cows. The aim of this study was to develop and evaluate the performance of a fully automated 2-dimensional…
A prospective cohort study examining the association of claw anatomy and sole temperature with the development of claw horn disruption lesions in dairy cattle Open
Foot characteristics have been linked to the development of sole lesions (sole hemorrhage and sole ulcers) and white line lesions, also known as claw horn disruption lesions (CHDL). The objective of this study was to examine the associatio…
Initial validation of an intelligent video surveillance system for automatic detection of dairy cattle lameness Open
Introduction Lameness is a major welfare challenge facing the dairy industry worldwide. Monitoring herd lameness prevalence, and early detection and therapeutic intervention are important aspects of lameness control in dairy herds. The obj…
View article: Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis
Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis Open
Objective To investigate the association between socioeconomic deprivation and outcomes following TNF inhibitor (TNFi) treatment. Methods Individuals commencing their first TNFi in the British Society for Rheumatology Biologics Register fo…
Specific pathway abundances in the neonatal calf faecal microbiome are associated with susceptibility to Cryptosporidium parvum infection: A metagenomic analysis Open
Background Cryptosporidium parvum is the main cause of calf scour globally. With limited therapeutic options and research compared to other Apicomplexa , it is important to understand the parasites’ biology and interactions with the host a…
Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models Open
Background Lameness in dairy cattle is primarily caused by foot lesions including the claw horn lesions (CHL) of sole haemorrhage (SH), sole ulcers (SU), and white line disease (WL). This study investigated the genetic architecture of the …
Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows Open
Sole hemorrhage and sole ulcers, referred to as sole lesions, are important causes of lameness in dairy cattle. We aimed to compare the serum metabolome of dairy cows that developed sole lesions in early lactation with that of cows that re…
Genetic parameters of sole lesion recovery in Holstein cows Open
Sole hemorrhage and sole ulcers, referred to as sole lesions, are important causes of lameness in dairy cattle. The objective of this study was to estimate the genetic parameters of a novel trait reflecting how well cows recovered from sol…
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions Open
Background Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene am…
Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows Open
The digital cushion is linked to the development of claw horn lesions (CHL) in dairy cattle. The objectives of this study were to (1) estimate genetic parameters for digital cushion thickness (DCT), (2) estimate the genetic correlation bet…
A Prospective Cohort Study on the Periparturient Muscle Tissue Mobilisation in High Producing Dairy Cows Open
Excessive periparturient fat mobilisation and its association with dairy cattle health and fertility is well documented; however, the role of muscle mobilisation has not been studied extensively. The objectives of this study were to (i) in…
View article: The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions Open
Background: Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. The polymicrobial nature of this disease has led to the hypothesis that the foot skin microbiota may b…
Diagnosis of Bovine Digital Dermatitis: Exploring the Usefulness of Indirect ELISA Open
The precision by which animal diseases are diagnosed affects our ability to make informed decisions with regards to animal health management, from a clinical and economic perspective. Lameness is a major health condition in dairy cattle. T…
Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial Open
Background The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD). Methods 158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated…
View article: The Bovine Foot Skin Microbiota is Associated with Host Genotype and the Development of Infectious Digital Dermatitis Lesions
The Bovine Foot Skin Microbiota is Associated with Host Genotype and the Development of Infectious Digital Dermatitis Lesions Open
Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. The polymicrobial nature of this disease has led to the hypothesis that the foot skin microbiota may be associated…
A study on the use of thermal imaging as a diagnostic tool for the detection of digital dermatitis in dairy cattle Open
Our aims were to (1) determine how interdigital skin temperature (IST), measured using infrared thermography, was associated with different stages of digital dermatitis (DD) lesions and (2) develop and validate models that can use IST meas…
188 Enhancing junior doctor leadership and management skills as innovation fellows Open
Aims The Site Innovation Lead at Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board appointed 12 junior doctors as Innovation Fellows in order to enhance their leadership and management skills. Methods Junior doctors competit…
A Prospective Cohort Study on the Development of Claw Horn Disruption Lesions in Dairy Cattle; Furthering our Understanding of the Role of the Digital Cushion Open
Claw horn disruption lesion (CHDL) is the collective term used to describe non-infectious foot lesions such as sole ulcers (SU), sole hemorrhage (SH), and white line disease (WLD) that commonly affect dairy cattle. The potential role of th…
16S rRNA amplicon sequencing reveals a polymicrobial nature of complicated claw horn disruption lesions and interdigital phlegmon in dairy cattle Open
Lameness represents an intractable problem for the dairy industry. Complicated claw horn disruption lesions, interdigital hyperplasia, and interdigital phlegmon are important lameness causing foot lesions. Their aetiology is multifactorial…
A Cross-Sectional Study Into the Prevalence of Dairy Cattle Lameness and Associated Herd-Level Risk Factors in England and Wales Open
Lameness is one of the most pressing issues within the dairy industry; it has severe economic implications while causing a serious impact on animal welfare. A study conducted approximately 10 years ago found the within farm lameness preval…