Bethany Mason
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View article: Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy
Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy Open
Flap endonuclease 1 (FEN1) is a structure-specific nuclease with critical functions in DNA replication and repair. FEN1 has been proposed as an anti-cancer drug target because of its synthetic lethal interaction with homologous recombinati…
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells Open
Repair of DNA damage is essential for the maintenance of genome stability and cell viability. DNA double strand breaks (DSBs) constitute a toxic class of DNA lesion and multiple cellular pathways exist to mediate their repair. Robust and t…
The FBXL family of F-box proteins: variations on a theme Open
The ubiquitin–proteasome system (UPS) is responsible for the rapid targeting of proteins for degradation at 26S proteasomes and requires the orchestrated action of E1, E2 and E3 enzymes in a well-defined cascade. F-box proteins (FBPs) are …
Functional Analysis of the F-box protein Fbxl17 Open
Advances in DNA sequencing technology have allowed detailed characterisation of cancer genomes and has highlighted the contribution of somatic structural variations to the mutational landscape of epithelial tumours. However, our understand…
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites Open
Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative. Components of the u…
Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway Open
The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with both sporadic Parkinson's dis…
Dependency of Heterochromatin Domains on Replication Factors Open
Chromatin structure regulates both genome expression and dynamics in eukaryotes, where large heterochromatic regions are epigenetically silenced through the methylation of histone H3K9, histone deacetylation, and the assembly of repressive…
Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast Open
Significance In recent years, high-throughput studies have revealed the organization of eukaryotic genomes into chromatin domains, topologically associated domains, and replication domains, laying out important principles for the spatiotem…