Bethany S. Strunk
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View article: Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i>
Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i> Open
The lipid phosphatase Fig4 is conserved in all eukaryotes and is associated with human neurological diseases for which there are currently no specific therapies. Fig4 functions in both the production and turnover of its lipid substrate, PI…
View article: Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold
Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold Open
The lipid phosphatase Fig4 modulates the production and turnover of the signaling lipid PI3,5P2 through participation in a complex with its opposing kinase, Fab1, and the scaffold protein Vac14. Fig4 point mutations are associated with neu…
View article: Abstract 1868 Fig4 Influences Cellular Homeostasis Through MAP Kinase Related Pathways
Abstract 1868 Fig4 Influences Cellular Homeostasis Through MAP Kinase Related Pathways Open
Fig4 is a highly conserved phosphoinositide (PI) phosphatase that plays crucial roles in human development and long-term health. Fig4 contributes to cellular homeostasis through dephosphorylating PI3,5P2 at the 5-position of the inositol h…
View article: Abstract 2455 Fig4 disease-related variants confer a Ste20-dependent growth advantage on rapamycin independent of Vac14
Abstract 2455 Fig4 disease-related variants confer a Ste20-dependent growth advantage on rapamycin independent of Vac14 Open
Fig4, a phosphoinositide (PI) lipid phosphatase, dephosphorylates the 5-position of the inositol ring of PI3,5P2, a low abundance and highly regulated signaling lipid. Mutations in Fig4 have been implicated in childhood-onset and developme…
View article: Abstract 2447 A Deep Learning Approach to Gene Function Prediction
Abstract 2447 A Deep Learning Approach to Gene Function Prediction Open
The increased accessibility of high-throughput biological experimentation has promised to revolutionize our understanding of cellular systems on a large scale. Bioinformatics enables the use of computer algorithms and machine learning to a…
View article: Roles for a lipid phosphatase in the activation of its opposing lipid kinase
Roles for a lipid phosphatase in the activation of its opposing lipid kinase Open
The phosphoinositide phosphatase Fig4 is predicted to turn over the signaling lipid PI3,5P2. It is shown that a major role of Fig4 is to elevate PI3,5P2 via dynamic regulation of the protein complex that activates its opposing lipid kinase…
View article: An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels
An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels Open
Phosphorylated phosphoinositide lipids (PPIs) are low-abundance signaling molecules that control signal transduction pathways and are necessary for cellular homeostasis. The PPI phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P 2 ) is esse…
View article: PI5P and PI(3,5)P<sub>2</sub>: Minor, but Essential Phosphoinositides
PI5P and PI(3,5)P<sub>2</sub>: Minor, but Essential Phosphoinositides Open
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low …