Bethany Stennett
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Sex‐dependent effects of alcohol intake on pain‐related functional activation Open
Background Alcohol analgesia (AA) is a well‐established phenomenon and important motivator of pain self‐medication with alcohol. Alcohol intoxication produces widespread alterations in many brain areas involved in pain processing. Sex and …
Insula under the influence: Alcohol‐induced changes in resting state functional connectivity Open
Background The insular cortex (IC), which includes anterior (AIC) and posterior (PIC) subdivisions, plays a role in numerous functions and behaviors, including chronic alcohol consumption. This study investigated acute alcohol effects on f…
Sex differences in associations between delay discounting and expectancies for alcohol analgesia. Open
Self-medication of pain with alcohol is prevalent, and expectancies for alcohol analgesia likely influence pain relief and alcohol consumption. Hazardous alcohol use has been associated with greater delay discounting rates; however, little…
Acute Tolerance to the Analgesic Effects of Alcohol Open
This study provides initial experimental evidence that alcohol's analgesic and pain-relieving effects are subject to acute tolerance following acute alcohol intake. These findings suggest that self-medicating pain via alcohol intake may be…
View article: CANUE: A Theoretical Model of Pain as an Antecedent for Substance Use
CANUE: A Theoretical Model of Pain as an Antecedent for Substance Use Open
Background Pain and substance use are frequently comorbid and have been shown to exert bidirectional effects. Self-medication of pain and distress via substance use is common and can be understood via negative reinforcement, ultimately str…
A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens Open
Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying cocaine seeking and to screen medications to reduce seeking. However, while the majority of cocaine users engage in poly-substance use (…
Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers Open
Background Acute alcohol intoxication has wide‐ranging neurobehavioral effects on psychomotor, attentional, inhibitory, and memory‐related cognitive processes. These effects are mirrored in disruption of neural metabolism, functional activ…
Regional increases in brain signal variability are associated with pain intensity reductions following repeated eccentric exercise bouts Open
Background Traditional pain interventions limit fluctuations in pain sensation, which may paradoxically impair endogenous pain modulatory systems (EPMS). However, controlled exposures to clinically relevant pain (e.g. delayed onset muscle …
Simultaneous edited MRS of GABA, glutathione, and ethanol Open
The aim of this work was to develop simultaneous edited MRS of γ‐aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA‐edited spectroscopy (HERMES) at 3T. Density‐matrix simulati…
Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of <span>S</span>prague–<span>D</span>awley rats without increasing spontaneous glutamate release Open
Glutamate neurotransmission in the nucleus accumbens core ( NA c) mediates ethanol consumption. Previous studies using non‐contingent and voluntary alcohol administration in inbred rodents have reported increased basal extracellular glutam…