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View article: Dysregulated miR-1246 and miR-1253 link inflammatory protein markers in plasma to major depressive disorder in female adolescents
Dysregulated miR-1246 and miR-1253 link inflammatory protein markers in plasma to major depressive disorder in female adolescents Open
Major depressive disorder (MDD) in adolescents is a prevalent psychiatric condition worldwide with severe consequences. Growing evidence shows that microRNAs (miRNAs) regulate many processes hypothesized to be involved in the pathogenesis …
View article: Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation
Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation Open
View article: The selective 5-HT<sub>2A</sub>receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents
The selective 5-HT<sub>2A</sub>receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents Open
Psychedelic-assisted psychotherapy has over the last decade emerged as a promising treatment strategy for mental health disease, and the therapeutic potential in classical psychedelics such as psilocybin, LSD and 5-MeO-DMT is presently bei…
View article: MicroRNAs underlying the antidepressant effect of psilocybin – Establishing an nCounter pipeline for microRNA-quantification in the pig brain
MicroRNAs underlying the antidepressant effect of psilocybin – Establishing an nCounter pipeline for microRNA-quantification in the pig brain Open
Novel treatment strategies are needed to overcome some of the current challenges related to treatment resistance and treatment latency within the psychiatric field. Recently, psilocybin has shown promise as a novel treatment of major depre…
View article: A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of depression
A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of depression Open
The N-methyl-D-aspartate receptor (NMDA-R) antagonist S-ketamine has been approved as a rapid-acting antidepressant for treatment-resistant depression (TRD). The antidepressant mechanisms have not fully been elucidated; however, alteration…
View article: EXTRACELLULAR VESICLE AND MIRNA RESPONSES TO REMOTE ISCHEMIC CONDITIONING IN STROKE PATIENTS
EXTRACELLULAR VESICLE AND MIRNA RESPONSES TO REMOTE ISCHEMIC CONDITIONING IN STROKE PATIENTS Open
View article: Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study Open
Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cel…
View article: Kappa opioid activation changes protein profiles in different regions of the brain relevant to depression
Kappa opioid activation changes protein profiles in different regions of the brain relevant to depression Open
Depression is a widespread disorder with a significant burden on individuals and society. There are various available treatments for patients with depression. However, not all patients respond adequately to their treatment. Recently, the o…
View article: Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation
Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation Open
Maternal immune system activation (MIA) during pregnancy can disrupt the fetal environment, causing postnatal susceptibility to disorders. How the placenta and the fetus respond to acute MIA over time is unknown. Here, we characterized the…
View article: Additional file 1 of Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Additional file 1 of Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study Open
Supplementary Material 1
View article: From microRNA to protein, linking the neurotrophic hypothesis of depression to the Wistar Kyoto rat
From microRNA to protein, linking the neurotrophic hypothesis of depression to the Wistar Kyoto rat Open
View article: Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation
Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation Open
View article: Single dose S-ketamine rescues transcriptional dysregulation of Mtor and Nrp2 in the prefrontal cortex of FSL rats 1 hour but not 14 days post dosing
Single dose S-ketamine rescues transcriptional dysregulation of Mtor and Nrp2 in the prefrontal cortex of FSL rats 1 hour but not 14 days post dosing Open
View article: A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats
A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats Open
Findings of the effect of high-fat feeding including “Cafeteria Diets” (CAF) on brain-derived neurotrophic factor (BDNF) in the hippocampus (HIP) and prefrontal cortex (PFC) in rodents are conflicting. CAF is a non-standardized, highly pal…
View article: Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task Open
View article: Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats
Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats Open
Objectives The purpose of the present study was to investigate whether intramuscular BoNT/A injections cause an systemic inflammatory response and a local inflammatory response in the muscle tissue. Methods Thirty-two male Sprague Dawley r…
View article: Structural Plasticity and Molecular Markers in Hippocampus of Male Rats after Acute Stress
Structural Plasticity and Molecular Markers in Hippocampus of Male Rats after Acute Stress Open
Stress plays a crucial role in the pathogenesis of psychiatric disorders and affects neuronal plasticity in different brain regions. We have previously found that acute foot-shock (FS) stress elicits fast and long-lasting functional and mo…
View article: Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression Open
Objectives: Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant depression, among them …
View article: Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients
Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients Open
Accumulating evidence suggests neuroinflammation to be an integrated feature of neurodegeneration. Profiling inflammatory mediators across diseases may reveal common and disease-specific signatures. Here, we focused on progressive supranuc…
View article: Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat
Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat Open
Objective: Psilocybin is a serotonin receptor agonist with a therapeutic potential for treatment-resistant depression and other psychiatric illnesses. We investigated whether the administration of psilocybin had an antidepressant-like effe…
View article: Elevated <i>P2×7r</i> and <i>P2×4r</i> transcripts levels in the Flinders Sensitive Line Rats, a genetic animal model of depression
Elevated <i>P2×7r</i> and <i>P2×4r</i> transcripts levels in the Flinders Sensitive Line Rats, a genetic animal model of depression Open
P2×7 and P2×4 receptors (P2×7R and P2×4R, respectively) are ligand-gated ion channels activated by adenosine triphosphate (ATP), which have been associated to dysfunctional processes in stress responses linked to depression, such as neurot…
View article: Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood
Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood Open
Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both…
View article: A Critical Role of Mitochondria in BDNF-Associated Synaptic Plasticity After One-Week Vortioxetine Treatment
A Critical Role of Mitochondria in BDNF-Associated Synaptic Plasticity After One-Week Vortioxetine Treatment Open
Our results imply that mitochondria play a critical role in synaptic plasticity accompanied by increased BDNF levels. Rapid changes in BDNF levels and synaptic/mitochondria plasticity of hippocampus following vortioxetine compared with flu…
View article: S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression
S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression Open
Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] in the antid…
View article: Mitochondria Are Critical for BDNF-Mediated Synaptic and Vascular Plasticity of Hippocampus following Repeated Electroconvulsive Seizures
Mitochondria Are Critical for BDNF-Mediated Synaptic and Vascular Plasticity of Hippocampus following Repeated Electroconvulsive Seizures Open
Our results indicate that rapid and efficient therapeutic effect of electroconvulsive seizures may be related to synaptic plasticity, accompanied by brain-derived neurotrophic factor protein level elevation and mitochondrial and vascular s…
View article: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents Open
View article: Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice
Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice Open
View article: The regulation of orexins and their cognate receptors in two distinct rat models of depression and effects of treatments
The regulation of orexins and their cognate receptors in two distinct rat models of depression and effects of treatments Open
Introduction Depression has sleep disturbances as a key symptom and recently sleep has been suggested as a new area to optimize treatment in depression. Orexin is produced in the hypothalamus and projected throughout the brain innervating …
View article: The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex
The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex Open
It is well established that stress plays a major role in the pathogenesis of neuropsychiatric diseases. Stress-induced alteration of synaptic plasticity has been hypothesized to underlie the morphological changes observed by neuroimaging i…
View article: Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review Open
A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the antidepressant effect…