Bettina Bohnhorst
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View article: Practical obstetric multi-professional training (PROMPT): the evidence for effective training
Practical obstetric multi-professional training (PROMPT): the evidence for effective training Open
Objective To test the hypothesis that Practical Obstetric Multi-Professional Training (PROMPT) is effective training. Background Multi-professional training in the labour ward has, in most cases, shown to be effective, in some cases not to…
View article: Tiny clots, big choices: intervening on neonatal aortic thrombosis—a novel framework for clinical decision-making
Tiny clots, big choices: intervening on neonatal aortic thrombosis—a novel framework for clinical decision-making Open
Background: Neonatal aortic thrombosis, though rare, is a critical condition with high morbidity and mortality. Spontaneous thrombosis is uncommon, complicating diagnosis due to its similarity to aortic coarctation. Standard treatments inc…
View article: Tiny Torsos, Tight Consensus: A Prospective Interobserver Study on Abdominal Ultrasound in Preterm Infants
Tiny Torsos, Tight Consensus: A Prospective Interobserver Study on Abdominal Ultrasound in Preterm Infants Open
Background Accurate organ measurement is essential in neonatal ultrasound in order to guide clinical decisions. However, interobserver variability remains a challenge, especially in preterm infants, where small organ dimensions and technic…
View article: Scans, stress, and solutions: The influence of ultrasound examinations on the daily work of nursing staff in a level III neonatal intensive care unit
Scans, stress, and solutions: The influence of ultrasound examinations on the daily work of nursing staff in a level III neonatal intensive care unit Open
View article: Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants
Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants Open
Aim Cardiorespiratory events such as apnea, bradycardia and hypoxemia are common in preterm infants and may contribute to an impaired neurodevelopmental outcome. We hypothesised a significant reduction in the incidence of hypoxemia, bradyc…
View article: Infant lung transplantation: First German experience including two cases of ABO blood group incompatible transplantations
Infant lung transplantation: First German experience including two cases of ABO blood group incompatible transplantations Open
View article: Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants Open
Importance Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to ne…
View article: Impact of Introducing PROMPT on Permanent Brachial Plexus Injury and Tears III°/IV° in Shoulder Dystocia: The Hanover Cohort Study
Impact of Introducing PROMPT on Permanent Brachial Plexus Injury and Tears III°/IV° in Shoulder Dystocia: The Hanover Cohort Study Open
Objective . To test the hypothesis that PROMPT reduces permanent brachial plexus palsy and perineal tears. Design . A prospective/retrospective cohort study. Setting . Hanover Medical School, Germany. Population/Sample . A self‐selected po…
View article: Treated Cases of Retinopathy of Prematurity in Germany
Treated Cases of Retinopathy of Prematurity in Germany Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: IMPACT OF INTRODUCING PROMPT ON PERMANENT BRACHIAL PLEXUS INJURY & TEARS °III/IV IN SHOULDER DYSTOCIA: THE HANOVER COHORT STUDY
IMPACT OF INTRODUCING PROMPT ON PERMANENT BRACHIAL PLEXUS INJURY & TEARS °III/IV IN SHOULDER DYSTOCIA: THE HANOVER COHORT STUDY Open
Objective: to test the hypothesis that PROMPT reduces permanent brachial plexus palsy and perinatal tears. Design: prospective / retrospective cohort study. Setting: Hanover Medical School, Germany. Population / Sample: a self-selected pop…
View article: Growth and Duration of Inflammation Determine Short- and Long-Term Outcome in Very-Low-Birth-Weight Infants Requiring Abdominal Surgery
Growth and Duration of Inflammation Determine Short- and Long-Term Outcome in Very-Low-Birth-Weight Infants Requiring Abdominal Surgery Open
Necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP) and meconium-related ileus (MI) requiring surgical intervention are associated with a high risk of severe short- and long-term complications in very-low-birth-weight…
View article: Epidemiology and infection control of Methicillin-resistant Staphylococcus aureus in a German tertiary neonatal intensive and intermediate care unit: A retrospective study (2013–2020)
Epidemiology and infection control of Methicillin-resistant Staphylococcus aureus in a German tertiary neonatal intensive and intermediate care unit: A retrospective study (2013–2020) Open
In preterm and term infants who require intermediate or intensive care Methicillin-resistant Staphylococcus aureus (MRSA) infection can lead to significant morbidity. In this study MRSA colonization and infection were assessed in a mixed t…
View article: Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period
Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period Open
We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk sa…
View article: Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation
Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation Open
Importance The inclusion of less invasive surfactant administration (LISA) in the care of preterm infants has been found to be beneficial for respiratory outcomes. Recently, the OPTIMIST trial found higher mortality rates in the subgroup o…
View article: Dead space washout by intentional leakage flow during conventional ventilation of premature infants—an experimental study
Dead space washout by intentional leakage flow during conventional ventilation of premature infants—an experimental study Open
Objective Invasive mechanical ventilation poses a strong risk factor for the development of chronic lung disease in preterm infants. A reduction of the dead space as part of the total breathing volume would reduce the ventilation effort an…
View article: Epidemiologie und Therapie der behandlungsbedürftigen Frühgeborenenretinopathie. Die Hannoveraner Daten im Retina.net ROP-Register von 2001 bis 2017
Epidemiologie und Therapie der behandlungsbedürftigen Frühgeborenenretinopathie. Die Hannoveraner Daten im Retina.net ROP-Register von 2001 bis 2017 Open
View article: Anatomic accuracy, physiologic characteristics, and fidelity of very low birth weight infant airway simulators
Anatomic accuracy, physiologic characteristics, and fidelity of very low birth weight infant airway simulators Open
Background Medical simulation training requires realistic simulators with high fidelity. This prospective multi-center study investigated anatomic precision, physiologic characteristics, and fidelity of four commercially available very low…
View article: Cardiorespiratory Events Following the Second Routine Immunization in Preterm Infants: Risk Assessment and Monitoring Recommendations
Cardiorespiratory Events Following the Second Routine Immunization in Preterm Infants: Risk Assessment and Monitoring Recommendations Open
Due to frequent cardiorespiratory events (CREs) in response to the first routine immunization (rIM), current guidelines recommend readmitting and monitoring extremely preterm infants after the second rIM, though evidence on CREs in respons…
View article: Severe fetal brain damage subsequent to acute maternal hypoxemic deterioration in <scp>COVID</scp>‐19
Severe fetal brain damage subsequent to acute maternal hypoxemic deterioration in <span>COVID</span>‐19 Open
Coronavirus disease 2019 (COVID-19) following severe acute respiratory syndrome coronavirus 2 infection can cause severe complications in pregnancy, impacting neonatal outcome. There is evidence that, during pregnancy, women become more su…
View article: Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period
Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period Open
Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life. The first 1000 days are regarded as a c…
View article: Detection of Breathing Movements of Preterm Neonates by Recording Their Abdominal Movements with a Time-of-Flight Camera
Detection of Breathing Movements of Preterm Neonates by Recording Their Abdominal Movements with a Time-of-Flight Camera Open
In order to deliver an aerosolized drug in a breath-triggered manner, the initiation of the patient’s inspiration needs to be detected. The best-known systems monitoring breathing patterns are based on flow sensors. However, due to their l…
View article: S100A8/A9 is the first predictive marker for neonatal sepsis
S100A8/A9 is the first predictive marker for neonatal sepsis Open
Neonatal sepsis is a leading cause of childhood mortality worldwide particularly affecting preterm infants, who are often exposed to empirical antibiotics since sepsis biomarkers lack sensitivity in this patient group and markers predictin…
View article: Detection of Serratia marcescens in neonatal intensive care units requires a rapid and comprehensive infection control response starting with the very first case
Detection of Serratia marcescens in neonatal intensive care units requires a rapid and comprehensive infection control response starting with the very first case Open
Background:Serratiamarcescens is a well-known and challenging pathogen in neonatal intensive care units. It is responsible for severe infections and can cause nosocomial outbreaks. Methods: We present the infection control response to a Se…
View article: Detection of Serratia marcescens in neonatal intensive care units requires a rapid and comprehensive infection control response starting with the very first case Der Nachweis bereits eines Serratia marcescens Falles auf einer neonatologischen Intensivstation bedarf schneller und umfassender Hygienemaßnahmen
Detection of Serratia marcescens in neonatal intensive care units requires a rapid and comprehensive infection control response starting with the very first case Der Nachweis bereits eines Serratia marcescens Falles auf einer neonatologischen Intensivstation bedarf schneller und umfassender Hygienemaßnahmen Open
View article: Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain—A new treatment strategy for neonatal seizures?
Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain—A new treatment strategy for neonatal seizures? Open
Objectives The loop diuretic bumetanide has been proposed previously as an adjunct treatment for neonatal seizures because bumetanide is thought to potentiate the action of γ‐aminobutyric acid (GABA)ergic drugs such as phenobarbital by pre…
View article: Application of two different nasal CPAP levels for the treatment of respiratory distress syndrome in preterm infants—“The OPTTIMMAL-Trial”—Optimizing PEEP To The IMMAture Lungs: study protocol of a randomized controlled trial
Application of two different nasal CPAP levels for the treatment of respiratory distress syndrome in preterm infants—“The OPTTIMMAL-Trial”—Optimizing PEEP To The IMMAture Lungs: study protocol of a randomized controlled trial Open
View article: Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms
Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms Open
View article: Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age
Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age Open
View article: Impact of maternal education on the outcome of newborns requiring surgery for congenital malformations
Impact of maternal education on the outcome of newborns requiring surgery for congenital malformations Open
Low maternal education is associated with a reduced uptake of prenatal screenings, adverse neonatal outcomes, and higher incidence of postoperative complications in newborns with congenital anomalies. Primary prevention and specific suppor…
View article: Der kleine Fall aus der Neonatologie: Stockfisch und blaue Lippen
Der kleine Fall aus der Neonatologie: Stockfisch und blaue Lippen Open
Schlüsselwörter Zyanose - erworbene Methämoglobinämie - hereditäre Methämoglobinämie - Hämoglobinanomalie Typ Hb-M Osaka