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View article: Cytohesin-2 is essential for the survival of mice and regulates Golgi volume and function
Cytohesin-2 is essential for the survival of mice and regulates Golgi volume and function Open
Proteins of the cytohesin family are known for their guanine-nucleotide exchange factor function for ARF-GTPases, mainly for ARF1 and ARF6. While Arf1 and Arf6 deficiency results in embryonic lethality, in vivo functions of cytohesins are …
View article: Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos
Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos Open
The transition of an embryo from gastrulation to organogenesis requires precisely coordinated changes in gene expression, but the underlying mechanisms remain unclear. The RNA-binding protein Trim71 is essential for development and serves …
View article: <i>TRIM71</i> mutations cause a neurodevelopmental syndrome featuring ventriculomegaly and hydrocephalus
<i>TRIM71</i> mutations cause a neurodevelopmental syndrome featuring ventriculomegaly and hydrocephalus Open
Congenital hydrocephalus, characterized by cerebral ventriculomegaly, is one of the most common reasons for paediatric brain surgery. Recent studies have implicated lin-41 (lineage variant 41)/TRIM71 (tripartite motif 71) as a candidate co…
View article: Differential impact of high-salt levels in vitro and in vivo on macrophage core functions
Differential impact of high-salt levels in vitro and in vivo on macrophage core functions Open
View article: Differential impact of high-salt levels in vitro and in vivo on macrophage core functions
Differential impact of high-salt levels in vitro and in vivo on macrophage core functions Open
The consumption of processed food is on the rise leading to huge intake of excess dietary salt, which strongly correlates with development of hypertension, often leading to cardiovascular diseases such as stroke and heart attack, as well a…
View article: Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus Open
View article: The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21
The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21 Open
Nonsense-mediated decay (NMD) plays a fundamental role in the degradation of premature termination codon (PTC)-containing transcripts, but also regulates the expression of functional transcripts lacking PTCs, although such ‘non-canonical’ …
View article: Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion
Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion Open
Insulin plays a central role in regulating metabolic homeostasis and guanine-nucleotide exchange factors of the cytohesin family have been suggested to be involved in insulin signal transduction. The Drosophila homolog of cytohesin-3, step…