Madhusoothanan B. Perumal
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View article: A Novel Biophysical Model for the Generation of Sharp Wave Ripples in CA1 Hippocampus
A Novel Biophysical Model for the Generation of Sharp Wave Ripples in CA1 Hippocampus Open
Synchronous activities among neurons in the brain generate emergent network oscillations such as the hippocampal Sharp-wave ripples (SPWRs) that facilitate information processing during memory formation. However, how neurons and circuits a…
View article: High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons Open
Dendritic spikes function as cardinal components of rodent neocortical circuit computations. Recently, the biophysical properties of human pyramidal neurons (PNs) have been reported to be divergent, raising the question of whether dendriti…
View article: High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons Open
Dendritic computations have a central role in rodent neocortical circuit function, which are signaled into neuronal output by the initiation and propagation of regenerative dendritic spikes. However, it remains poorly explored whether thes…
View article: Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons
Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons Open
Synchronized activity in neural circuits, detected as oscillations in the extracellular field potential, has been associated with learning and memory. Neural circuits in the basolateral amygdala (BLA), a mid-temporal lobe structure, genera…
View article: Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory
Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory Open
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones. A diverse population of GABAergic neurons present in…
View article: Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala
Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala Open
We have previously shown that in the basolateral amygdala (BLA), action potentials in one type of parvalbumin (PV)-expressing GABAergic interneuron can evoke a disynaptic feedback excitatory postsynaptic potential (fbEPSP) onto the same pr…