Bharati Matta
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View article: IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation 2897
IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation 2897 Open
Description Although dynamic alterations in transcriptional, translational, and metabolic programs have been described in T cells, the factors and pathways guiding these molecular shifts are poorly understood, with recent studies revealing…
View article: TLR-induced STK25 activation promotes IRF5-mediated inflammation
TLR-induced STK25 activation promotes IRF5-mediated inflammation Open
The transcription factor interferon regulatory factor 5 (IRF5) functions as an important mediator of the inflammatory response downstream of MyD88-dependent TLRs. Whereas dysregulation of IRF5 activity has been implicated in the developmen…
View article: Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients
Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients Open
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We prev…
View article: <scp>IRF5</scp> Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger
<span>IRF5</span> Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger Open
Elevated levels of serum autoantibodies are a hallmark of systemic lupus erythematosus (SLE) and are produced by plasma cells in response to a variety of antigenic triggers. In SLE, the triggers are complex and may include both T cell‐depe…
View article: IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation
IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation Open
Although dynamic alterations in transcriptional, translational, and metabolic programs have been described in T cells, the factors and pathways guiding these molecular shifts are poorly understood, with recent studies revealing a disassoci…
View article: IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation Open
Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation. Little is known of th…
View article: Interferon regulatory factor 5 modulates microglia response to tau by interfering with phagocytosis
Interferon regulatory factor 5 modulates microglia response to tau by interfering with phagocytosis Open
Background The role of the immune system in responding to neurodegenerative pathology is well established. Microglia are at the center of such response, conveying on one end a positive protective effect, but on the other end, as with senes…
View article: Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis Open
Background Cancer–testis (CT) genes are targets for tumor antigen-specific immunotherapy given that their expression is normally restricted to the immune-privileged testis in healthy individuals with aberrant expression in tumor tissues. W…
View article: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation Open
Toll-like receptors (TLRs) represent a subset of pattern-recognition receptors (PRRs) employed by the innate immune system to detect pathogen-associated molecular patterns (PAMPs) and initiate the response to invading microbes. The transcr…
View article: Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis Open
Background Cancer-testis (CT) genes are targets for tumor antigen-specific immunotherapy given that their expression is normally restricted to the immune-privileged testis in healthy individuals with aberrant expression in tumor tissues. W…
View article: A New Methodology for the Quantification of Neutrophil Extracellular Traps in Patient Plasma
A New Methodology for the Quantification of Neutrophil Extracellular Traps in Patient Plasma Open
Neutrophil extracellular traps (NETs) are web-like structures made up of decondensed chromatin fibers along with neutrophil granular proteins that are extruded by neutrophils after activation or in response to foreign microorganisms. NETs …
View article: Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk
Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk Open
Neutrophil extracellular traps (NETs) are web-like structures extruded by neutrophils after activation or in response to microorganisms. These extracellular structures are decondensed chromatin fibers loaded with antimicrobial granular pro…
View article: Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization Open
The rational targeting of a transcription factor, interferon regulatory factor 5 (IRF5), inhibits downstream functions.
View article: IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE
IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE Open
Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk haplotype is common across populations, yet immune functions…
View article: Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis
Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis Open
TGF-β2 plays a critical role in regulation of intraocular inflammation in EAAU. Findings reported in this study improve our understanding of immunopathology of IAU and suggest that recombinant TGF-β2 may be a promising therapeutic agent fo…
View article: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes
Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes Open
Unmasking an agent of inflammatory anemia Infectious and autoimmune diseases are associated with anemia and thrombocytopenia. A severe form of inflammatory cytopenia called macrophage activation syndrome (MAS) may occur during rheumatologi…
View article: Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based? Open
The interferon regulatory factors (IRFs) are a family of master transcription factors that regulate pathogen-induced innate and acquired immune responses. Aberration(s) in IRF signaling pathways due to infection, genetic predisposition and…
View article: GG-03 <i>IRF5</i> genetic risk variants drive an SLE immune-phenotype in healthy donors
GG-03 <i>IRF5</i> genetic risk variants drive an SLE immune-phenotype in healthy donors Open
Background Gene expression profiling has provided significant insight into SLE pathology through the identification of an IFN gene signature, a neutrophil-specific signature, and a plasma cell signature that correlate with disease activity…
View article: Interferon regulatory factor signaling in autoimmune disease
Interferon regulatory factor signaling in autoimmune disease Open
View article: Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality
Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality Open
Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors. IRF5 was first identified and characterized as a transcriptional regulator of type I interferon expression after virus infection. In addition to …