Bhaskar Saha
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View article: Manipulation of macrophage signaling by <i>Leishmania</i> virulence factors
Manipulation of macrophage signaling by <i>Leishmania</i> virulence factors Open
Leishmania, a macrophage-residing parasite, expresses virulence factors that intercept macrophage signaling and inflicts leishmaniasis. Recently described virulence factors- eEF-1α (eukaryotic elongation factor), LmjF_36_3850 (Le…
View article: KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival
KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival Open
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, most tumors are heterogeneous …
View article: Causal inferences behind patient preference to seek physical therapy: a cross-sectional study
Causal inferences behind patient preference to seek physical therapy: a cross-sectional study Open
Background Rehabilitation programs after various diseases improve recovery and impact patient quality of life. However, patient participation is still deficient due to patient perspective and referral practice. Purpose To identify the exte…
View article: Mysterious Virus Nipah: A Comprehensive Review
Mysterious Virus Nipah: A Comprehensive Review Open
Nipah virus is regarded as one of the most notorious and infectious viruses in the world with high mortality. This narrative literature review aims to offer basic information on the epidemiology, transmission methods, pathophysiology, trea…
View article: PD-1/PD-L1 and PD-1/PD-L2 axes-targeted anti-leishmanial therapy
PD-1/PD-L1 and PD-1/PD-L2 axes-targeted anti-leishmanial therapy Open
Although programmed cell death protein-1 (PD-1) is expressed on CD4+ T, CD8+ T and B cells, the T cell expression of PD-1 and macrophages’ expression of its ligands- PD-L1 and PD-L2 increase during leishmaniasis. The PD-1/PD-L1 interaction…
View article: High monocytic MDSC signature predicts multi-drug resistance and cancer relapse in non-Hodgkin lymphoma patients treated with R-CHOP
High monocytic MDSC signature predicts multi-drug resistance and cancer relapse in non-Hodgkin lymphoma patients treated with R-CHOP Open
Introduction Non-Hodgkin Lymphoma (NHL) is a heterogeneous lymphoproliferative malignancy with B cell origin. Combinatorial treatment of rituximab, cyclophsphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) is the standard treatmen…
View article: Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase
Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase Open
Ascorbic acid is a redox regulator in many physiological processes. Besides its antioxidant activity, many intriguing functions of ascorbic acid in the expression of immunoregulatory genes have been suggested. Ascorbic acid acts as a co‐fa…
View article: Targeting multiple SARS-CoV-2 domains by Indian medicinal plants – A Drug repurposing study using molecular docking, ADME-Tox analysis
Targeting multiple SARS-CoV-2 domains by Indian medicinal plants – A Drug repurposing study using molecular docking, ADME-Tox analysis Open
The rapid transmission of SARS-CoV-2 and its capability to spread in humans has brought about the development of new approaches for treatment against COVID-19. Drugs and vaccines available currently either target the virus ectodomain or en…
View article: Isoform‐specific functions of Ras in T‐cell development and differentiation
Isoform‐specific functions of Ras in T‐cell development and differentiation Open
Ras GTPases, well characterized for their role in oncogenesis, are the cells’ molecular switches that signal to maintain immune homeostasis through cellular development, proliferation, differentiation, survival, and apoptosis. In the immun…
View article: CD40 induces selective routing of Ras isoforms to subcellular compartments
CD40 induces selective routing of Ras isoforms to subcellular compartments Open
Ras GTPases are central to cellular signaling and oncogenesis. The three loci of the Ras gene encode for four protein isoforms namely Harvey-Ras (H-Ras), Kirsten-Ras (K-Ras 4A and 4B), and Neuroblastoma-Ras (N-Ras) which share ~ 80% sequen…
View article: Regulation of Ras-GTPase Signaling and Localization by Post-Translational Modifications
Regulation of Ras-GTPase Signaling and Localization by Post-Translational Modifications Open
Ras, a GTP-GDP binary switch protein, transduces signals from diverse receptors to regulate various signaling networks. Three Ras genes encode for protein isoforms, namely, Harvey Ras (H-Ras), Kirsten Ras (K-Ras, with two splice variants, …
View article: Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination
Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination Open
Background Multiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by activated neuroglial cells, CNS infiltrating leukocytes, and their reciprocal interactions through inflammatory signals. An inflamma…
View article: Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation
Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation Open
Background: Bone remodeling is a balanced, dynamic function of two counteractive processes: osteoblasts-mediated bone formation and osteoclasts-dependent bone resorption. An imbalance between these two processes causes bone diseases. Herei…
View article: NEUROPROTECTIVE ACTIVITIES AND REPAIR MECHANISMS OF GINKGO BILOBA EXTRACT EGB 761 ON CNS INJURIES AND NEURODEGENERATIVE DISORDERS
NEUROPROTECTIVE ACTIVITIES AND REPAIR MECHANISMS OF GINKGO BILOBA EXTRACT EGB 761 ON CNS INJURIES AND NEURODEGENERATIVE DISORDERS Open
With an increasing number of neurodegenerative diseases and brain injuries, the focus of the research using synthetic and herbal medicines with an objective to treat the existing problems in neuroscience is ever-increasing. The availabilit…
View article: Battery management based on internal optical sensing
Battery management based on internal optical sensing Open
A battery management system includes one or more fiber optic sensors configured to be disposed within an electrochemical battery. Each fiber optic sensor is capable of receiving input light and providing output light that varies based on t…
View article: Method and system to separate optically measured coupled parameters
Method and system to separate optically measured coupled parameters Open
A system includes a first optical sensor sensitive to both a parameter of interest, Parameter1, and at least one confounding parameter, Parameter2 and a second optical sensor sensitive only to the confounding parameter. Measurement circuit…
View article: Olive leaves extract alleviates inflammation and modifies the intrinsic apoptotic signal in the leukemic bone marrow
Olive leaves extract alleviates inflammation and modifies the intrinsic apoptotic signal in the leukemic bone marrow Open
Introduction Current anti-leukemic chemotherapies with multiple targets suffer from side effects. Synthetic drugs with huge off-target effects are detrimental to leukemic patients. Therefore, natural plant-based products are being increasi…
View article: 2022-RA-437-ESGO Meta-analyses reveal serum or plasma interleukin-6 as a biomarker for malignant ovarian neoplasia
2022-RA-437-ESGO Meta-analyses reveal serum or plasma interleukin-6 as a biomarker for malignant ovarian neoplasia Open
View article: Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis
Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis Open
As effector innate immune cells and as a host to the protozoan parasite Leishmania , macrophages play a dual role in antileishmanial immunoregulation. The 2 key players in this immunoregulation are the macrophage-expressed microRNAs (miRNA…
View article: P1255: TUMOR-ASSOCIATED MONOCYTIC MYELOID DERIVED SUPPRESSOR CELLS IS A POTENTIAL PROGNOSTIC BIOMARKER, PROMOTING MULTI-DRUG RESISTANCE IN NHL PATIENTS BY MODULATING IL-6/IL-10/IL-1Β AXIS
P1255: TUMOR-ASSOCIATED MONOCYTIC MYELOID DERIVED SUPPRESSOR CELLS IS A POTENTIAL PROGNOSTIC BIOMARKER, PROMOTING MULTI-DRUG RESISTANCE IN NHL PATIENTS BY MODULATING IL-6/IL-10/IL-1Β AXIS Open
Background: Non-Hodgkin-Lymphoma (NHL), the most prevalent hematologic malignancies in the world has majorly originates from B cells. R-CHOP represents the new-standard treatment regimen for NHL. Most NHL patients initially respond to chem…
View article: Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-Coronavirus
Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-Coronavirus Open
The neurological disease Multiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by the activated glial cells, the CNS infiltrating leukocytes, and their reciprocal interaction through inflammatory sign…
View article: Oral Therapy Using a Combination of Nanotized Antimalarials and Immunomodulatory Molecules Reduces Inflammation and Prevents Parasite Induced Pathology in the Brain and Spleen of P. berghei ANKA Infected C57BL/6 Mice
Oral Therapy Using a Combination of Nanotized Antimalarials and Immunomodulatory Molecules Reduces Inflammation and Prevents Parasite Induced Pathology in the Brain and Spleen of P. berghei ANKA Infected C57BL/6 Mice Open
In malaria, anti-parasite immune response of the host may lead to dysregulated inflammation causing severe neuropathology arising from extensive damage to the Blood Brain Barrier (BBB). Use of anti-malarial drugs alone can control parasite…
View article: CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination
CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination Open
Neurotropic mouse hepatitis virus (MHV-A59/RSA59) infection in mice induces acute neuroinflammation due to direct neural cell dystrophy, which proceeds with demyelination with or without axonal loss, the pathological hallmarks of human neu…
View article: The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts
The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts Open
Bone metabolism is essential for maintaining bone mineral density and bone strength through a balance between bone formation and bone resorption. Bone formation is associated with osteoblast activity whereas bone resorption is linked to os…
View article: A Conceptual Design Approach for Women Safety Through Better Communication Design
A Conceptual Design Approach for Women Safety Through Better Communication Design Open
View article: Ras Isoforms from Lab Benches to Lives—What Are We Missing and How Far Are We?
Ras Isoforms from Lab Benches to Lives—What Are We Missing and How Far Are We? Open
The central protein in the oncogenic circuitry is the Ras GTPase that has been under intense scrutiny for the last four decades. From its discovery as a viral oncogene and its non-oncogenic contribution to crucial cellular functioning, an …
View article: TLR2 dimer‐specific ligands selectively activate protein kinase C isoforms in <i>Leishmania</i> infection
TLR2 dimer‐specific ligands selectively activate protein kinase C isoforms in <i>Leishmania</i> infection Open
Of the thirteen Toll‐like receptors (TLRs) in mice, TLR2 has a unique ability of forming heterodimers with TLR1 and TLR6. Such associations lead to selective cellular signalling and cellular responses such as cytokine expression. One of th…
View article: Author response for "Immunological role of keratinocytes in leishmaniasis"
Author response for "Immunological role of keratinocytes in leishmaniasis" Open
View article: Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India
Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India Open
Artemisinin is the frontline fast-acting anti-malarial against P. falciparum . Emergence and spread of resistant parasite in eastern-India poses a threat to national malaria control programs. Therefore, the objective of our study is to eva…
View article: Interdependencies between Toll‐like receptors in <i>Leishmania</i> infection
Interdependencies between Toll‐like receptors in <i>Leishmania</i> infection Open
Multiple pathogen‐associated molecular patterns (PAMPs) on a pathogen's surface imply their simultaneous recognition by the host cell membrane‐located multiple PAMP‐specific Toll‐like receptors (TLRs). The TLRs on endosomes recognize inter…