Balasubramanian Venkatesh
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View article: The influence of consent models on recruitment rates in randomised trials in critical care: A systematic review
The influence of consent models on recruitment rates in randomised trials in critical care: A systematic review Open
PROSPERO Record ID: Record ID: CRD42020215950.
View article: Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the <scp>STEPCARE</scp> Trial
Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the <span>STEPCARE</span> Trial Open
Background The international multi‐center randomized controlled STEPCARE‐trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out‐of‐hospital cardiac arrest (OHCA) pa…
View article: Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial
Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial Open
NCT06409364.
View article: Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (<scp>MAP</scp>‐<scp>CARE</scp>): A protocol for a randomized clinical trial
Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (<span>MAP</span>‐<span>CARE</span>): A protocol for a randomized clinical trial Open
Background In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac ar…
View article: Accuracy of the modified Global Burden of Disease International Classification of Diseases coding methods for identifying sepsis: A prospective multicentre cohort study
Accuracy of the modified Global Burden of Disease International Classification of Diseases coding methods for identifying sepsis: A prospective multicentre cohort study Open
Background: This study assessed the accuracy of three International Classification of Diseases (ICD) codes methods derived from Global Burden of Disease (GBD) sepsis study (modified GBD method) in identifying sepsis, compared to the Angus …
View article: Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (<scp>TEMP</scp>‐<scp>CARE</scp>): A study protocol for a randomized clinical trial
Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (<span>TEMP</span>‐<span>CARE</span>): A study protocol for a randomized clinical trial Open
Background Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback‐controlled device impacts patient‐centered outcomes in cardiac arrest patients. This trial aims to investigate fe…
View article: Sedation, temperature and pressure after cardiac arrest and resuscitation—The <scp>STEPCARE</scp> trial: A statistical analysis plan
Sedation, temperature and pressure after cardiac arrest and resuscitation—The <span>STEPCARE</span> trial: A statistical analysis plan Open
Background Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets for blood pressure and managing sedation and temperature. However, op…
View article: Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (<scp>SED</scp>‐<scp>CARE</scp>): A protocol for a randomized clinical trial
Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (<span>SED</span>‐<span>CARE</span>): A protocol for a randomized clinical trial Open
Background Sedation is often provided to resuscitated out‐of‐hospital cardiac arrest (OHCA) patients to tolerate post‐cardiac arrest care, including temperature management. However, the evidence of benefit or harm from routinely administer…
View article: A Core Outcome Set for Adult General ICU Patients
A Core Outcome Set for Adult General ICU Patients Open
OBJECTIVES: Randomized clinical trials informing clinical practice (e.g., like large, pragmatic, and late-phase trials) should ideally mostly use harmonized outcomes that are important to patients, family members, clinicians, and researche…
View article: Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method
Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method Open
Using a Delphi method, international experts reached consensus to generate expert clinical practice statements providing guidance to clinicians worldwide on the management of sepsis in resource-limited settings. These statements complement…
View article: Sepsis associated acute kidney injury is common among Aboriginal and Torres Strait Islanders with septic shock and has poor outcomes: A nested cohort study
Sepsis associated acute kidney injury is common among Aboriginal and Torres Strait Islanders with septic shock and has poor outcomes: A nested cohort study Open
Exploration of the incidence and outcomes of Acute Kidney Injury (AKI) broadly, and sepsis associated AKI specifically, in Aboriginal and Torres Strait Islander (First Nations) people has been limited. We compared a nested cohort of First …
View article: Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial
Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial Open
Background The combination of intravenous hydrocortisone and enteral fludrocortisone may reduce mortality in patients with septic shock. The optimal dose and reliability of absorption of fludrocortisone in critically ill patients are uncle…
View article: A multicentre point prevalence study of nocturnal hours awake and enteral pharmacological sleep aids in patients admitted to Australian and New Zealand intensive care units
A multicentre point prevalence study of nocturnal hours awake and enteral pharmacological sleep aids in patients admitted to Australian and New Zealand intensive care units Open
Patients not receiving invasive ventilation appeared to spend many nocturnal hours awake. Pharmacological sleep aid administration was not associated with a greater observed time asleep. Most patients did not receive any non-pharmacologica…
View article: A core outcome set for adult general ICU patients
A core outcome set for adult general ICU patients Open
Purpose Randomised clinical trials should ideally use harmonised outcomes that are important to patients and to facilitate meta-analyses and ensuring generalisability. Core outcome sets for specific subsets of ICU patients exist, e.g., res…
View article: Empirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study
Empirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study Open
Background Critically ill patients in intensive care units (ICU) are frequently administered broad‐spectrum antibiotics (e.g., carbapenems or piperacillin/tazobactam) for suspected or confirmed infections. This retrospective cohort study a…
View article: A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients
A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients Open
OBJECTIVES: We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used to identify pathways of potential importance for understanding sepsis pathophysiology. DESIGN: Retrospective…
View article: REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial
REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial Open
Background The REVISE ( R e- Ev aluating the I nhibition of S tress E rosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically ill patients. Object…
View article: REVISE: <i>R</i> e- <i>Ev</i> aluating the <i>I</i> nhibition of <i>S</i> tress <i>E</i> rosions in the ICU: a randomised trial protocol
REVISE: <i>R</i> e- <i>Ev</i> aluating the <i>I</i> nhibition of <i>S</i> tress <i>E</i> rosions in the ICU: a randomised trial protocol Open
Introduction The R e- Ev aluating the I nhibition of S tress E rosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI) bleeding…
View article: Dexamethasone doses in patients with <scp>COVID</scp>‐19 and hypoxia: <scp>A</scp> systematic review and meta‐analysis
Dexamethasone doses in patients with <span>COVID</span>‐19 and hypoxia: <span>A</span> systematic review and meta‐analysis Open
Background The optimal dose of dexamethasone for severe/critical COVID‐19 is uncertain. We compared higher versus standard doses of dexamethasone in adults with COVID‐19 and hypoxia. Methods We searched PubMed and trial registers until 23 …
View article: Selective digestive tract decontamination in critically ill adults with acute brain injuries: a Post-Hoc analysis of a Randomized Clinical Trial.
Selective digestive tract decontamination in critically ill adults with acute brain injuries: a Post-Hoc analysis of a Randomized Clinical Trial. Open
Purpose: To determine whether Selective Decontamination of the Digestive Tract (SDD) reduces in-hospital mortality in mechanically ventilated critically ill adults admitted to the Intensive Care Unit (ICU) with acute brain injuries or cond…