Bhupender S. Chhikara
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View article: Polycystic Ovary Syndrome (PCOS)-Specific Risk Appraisal of the Sunscreen Ultraviolet (UV) Filters (Oxybenzone/Octinoxate)
Polycystic Ovary Syndrome (PCOS)-Specific Risk Appraisal of the Sunscreen Ultraviolet (UV) Filters (Oxybenzone/Octinoxate) Open
Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder affecting 6–20% of women of reproductive age, manifesting through hyperandrogenism, ovulatory dysfunction, insulin resistance, and diverse metabolic derangements. I…
View article: Novel small molecule drugs approved by FDA in 2024 for cancer therapy
Novel small molecule drugs approved by FDA in 2024 for cancer therapy Open
Cancer remains a leading cause of mortality each year and is increasingly emerging as a significant threat to public health due to its rising incidence rates Various types of cancers, prioritized for treatment, are managed through distinct…
View article: Heart disease prediction using Machine learning and cardiovascular therapeutics development using molecular intelligence simulations: A perspective review
Heart disease prediction using Machine learning and cardiovascular therapeutics development using molecular intelligence simulations: A perspective review Open
View article: Signaling and molecular pathways implicated in oral cancer: A concise review
Signaling and molecular pathways implicated in oral cancer: A concise review Open
Oral cancer is the sixth most prevalent type of cancer worldwide and third in India out of the different cancer types identified. Mouth and oral cancers collectively refer to cancers of the buccal cavity, lips, oropharynx, hypopharynx, and…
View article: Nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) with repercussions toward apoptosis, necrosis, and cancer necrosis factor (TNF-α) at nano-biointerfaces
Nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) with repercussions toward apoptosis, necrosis, and cancer necrosis factor (TNF-α) at nano-biointerfaces Open
Introduction Apoptosis, necrosis, and cancer necrosis factor (TNF-a) are all impacted by the nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) at nano-biointerfaces. The creation of multi-functional nanopa…
View article: Reproductive toxicity of combined effects of endocrine disruptors on human reproduction
Reproductive toxicity of combined effects of endocrine disruptors on human reproduction Open
Confluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and…
View article: Genomes of extinct hominins and human reproductive evolution.
Genomes of extinct hominins and human reproductive evolution. Open
View article: Synthesis and Biological Evaluation of 5′-O-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides
Synthesis and Biological Evaluation of 5′-O-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides Open
A number of 5′-O-fatty acyl derivatives of 3′-fluoro-2′,3′-dideoxythymidine (FLT, 1) were synthesized. These conjugates were evaluated for their potential as topical microbicides with anti-HIV activity against cell-free (X4 and R5), cell-a…
View article: Chemerin and male reproduction: ‘a tangled rope’ connecting metabolism and inflammation
Chemerin and male reproduction: ‘a tangled rope’ connecting metabolism and inflammation Open
Adipokines are peptides produced mainly by the fat tissue adipocytes and their levels are sensitive to alterations in metabolic state. While there is little known about the impact of adipokines on male reproductive control, both animal-bas…
View article: Immunoendocrine regulation of energy homeostasis and male reproduction
Immunoendocrine regulation of energy homeostasis and male reproduction Open
Human reproductive system involve a number of intricate complex interconnected physiological metabolic pathways and metabolites with involvement of overall health of different body organs. Overall health alterations mediated physiological …
View article: Adropin in immune and energy balance: ‘a molecule of interest’ in male reproduction
Adropin in immune and energy balance: ‘a molecule of interest’ in male reproduction Open
Adropin is a novel peptide hormone with multidimensional functionalities awaiting to be unveiled completely. This hormone is encoded by the ‘energy homeostasis-associated’ ( Enho ) gene. It is primarily produced by the liver, while to some…
View article: Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout
Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout Open
Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynur…
View article: Cleaning the molecular machinery of cells <i>via</i> proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular perturbations
Cleaning the molecular machinery of cells <i>via</i> proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular perturbations Open
Schematic of the regulation of the ubiquitin-protein ligases and ubiquitylation, a dynamic cellular process for stability, and induced protein folding; the ubiquitin-conjugation machinery for accurate surveillance, cell cycle arrest, DNA d…
View article: Experimental and Computational Studies of Microwave-Assisted, Facile Ring Opening of Epoxide with Less Reactive Aromatic Amines in Nitromethane
Experimental and Computational Studies of Microwave-Assisted, Facile Ring Opening of Epoxide with Less Reactive Aromatic Amines in Nitromethane Open
Nucleophilic ring opening reactions of epoxides with aromatic amines are in the forefront of the synthetic organic chemistry research to build new bioactive scaffolds. Here, convenient, green, and highly efficient regioselective ring openi…
View article: Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations
Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations Open
N1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, fol…
View article: Reproductive Inflammatory Mediators and Male Infertility
Reproductive Inflammatory Mediators and Male Infertility Open
Disruption of semen quality in cases of testicular and accessory gland infections, owe to altered spermatogenesis, sperm maturation and/or transport. The impact depends on the intensity, duration of progression, mediators of the inflammato…
View article: Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics
Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics Open
The recent outbreak of Corona virus SARS-CoV-2 disease COVID-19 in the China and subsequent intermittent spread of infection to other countries has alarmed the medical and scientific community mainly because of lethal nature of this infect…
View article: Indian Medicinal Plants for skin care and cosmeceuticals: A review
Indian Medicinal Plants for skin care and cosmeceuticals: A review Open
The skin protects the internal organs, works as a complete physiological organ performing a number of functions. The skin itself is complex organ and its health impact the appearance and medical status of a human being. A number of herbal …
View article: Biosorption of metal toxicants and other water pollutants by Corn (Maize) plant: A comprehensive review
Biosorption of metal toxicants and other water pollutants by Corn (Maize) plant: A comprehensive review Open
The water pollution is one of major environmental and health issue. Various contaminants from effluents originating from different sources (domestic and industrial) and toxic metal ions along with few toxic anions from natural resources (u…
View article: Theoretical and experimental studies of an oseltamivir–triazole-based thermoresponsive organogel
Theoretical and experimental studies of an oseltamivir–triazole-based thermoresponsive organogel Open
Low-molecular weight organic gelators have been of significant interest in recent years because of their interesting properties and potential applications in sensing technology, biomedicine and drug delivery.
View article: Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors
Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors Open