Bhuvic Patel
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View article: The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors
The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors Open
Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of intracranial neoplasms that vary in hormonal activity, histological features, and clinical behavior. The rise of high-throughput sequencing and molecular profiling tech…
View article: Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions
Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions Open
Treatment resistance in glioblastoma (GBM) is largely driven by the extensive multi-level heterogeneity that typifies this disease. Despite significant progress toward elucidating GBM’s genomic and transcriptional heterogeneity, a critical…
View article: Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics Open
View article: NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas
NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas Open
Background World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drive…
View article: Four Transorbital Approaches to the Skull Base. Surgical Nuances and Institutional Experience with 195 Cases.
Four Transorbital Approaches to the Skull Base. Surgical Nuances and Institutional Experience with 195 Cases. Open
View article: Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution
Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution Open
An important subset of meningiomas behaves aggressively and is characterized by multiple recurrences. We identify clinical, genetic, and epigenetic predictors of multiply recurrent meningiomas (MRMs) and evaluate the evolution of these men…
View article: Anterolateral keyhole transorbital routes to the skull base: a comparative anatomical study
Anterolateral keyhole transorbital routes to the skull base: a comparative anatomical study Open
OBJECTIVE Although keyhole transorbital approaches are gaining traction, their indications have not been adequately studied comparatively. In this study the authors have defined them also as transwing approaches—meaning that they use the d…
View article: Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state
Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state Open
View article: Anterolateral and anteromedial transorbital approaches to the skull base: A quantitative and qualitative analysis.
Anterolateral and anteromedial transorbital approaches to the skull base: A quantitative and qualitative analysis. Open
View article: Minimally invasive lateral orbitotomy approach for middle fossa and orbital lesions
Minimally invasive lateral orbitotomy approach for middle fossa and orbital lesions Open
View article: PATH-13. APPLICATIONS OF SPATIAL TRANSCRIPTOMICS FOR THE DIAGNOSTICS OF GLIOMAS
PATH-13. APPLICATIONS OF SPATIAL TRANSCRIPTOMICS FOR THE DIAGNOSTICS OF GLIOMAS Open
Due to their infiltrative growth, diffuse gliomas can pose a major challenge for neuropathologists. Lack of specific immunohistochemistry markers for some gliomas like IDH-wildtype glioblastoma can make it hard to identify the tumour cell …
View article: NF2 Loss-of-Function and Hypoxia Drive Radiation Resistance in Grade 2 Meningiomas
NF2 Loss-of-Function and Hypoxia Drive Radiation Resistance in Grade 2 Meningiomas Open
Background World Health Organization Grade 2 meningiomas (G2Ms) exhibit an aggressive natural history characterized by recurrence and therapy resistance. G2Ms with histopathological necrosis have been associated with worse local control (L…
View article: Cranial Nerve IX and X Neurectomy for Glossopharyngeal Neuralgia: Case Report and Operative Video
Cranial Nerve IX and X Neurectomy for Glossopharyngeal Neuralgia: Case Report and Operative Video Open
BACKGROUND AND IMPORTANCE: Glossopharyngeal neuralgia (GPN) is a rare condition that is often misdiagnosed as trigeminal neuralgia. The condition is characterized by intermittent, severe pain in the distribution of the glossopharyngeal ner…
View article: Corrigendum: Identification and management of aggressive meningiomas
Corrigendum: Identification and management of aggressive meningiomas Open
[This corrects the article DOI: 10.3389/fonc.2022.851758.].
View article: Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state
Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state Open
Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to the pathogenesis of these tumors remains poorly understood. W…
View article: TMIC-05. SINGLE-CELL MULTI-OMIC ANALYSIS OF SPORADIC VESTIBULAR SCHWANNOMAS REVEALS SCHWANN CELLS WITH AN INJURY PHENOTYPE AND AN ASSOCIATION BETWEEN TUMOR SIZE AND MACROPHAGE INFILTRATE
TMIC-05. SINGLE-CELL MULTI-OMIC ANALYSIS OF SPORADIC VESTIBULAR SCHWANNOMAS REVEALS SCHWANN CELLS WITH AN INJURY PHENOTYPE AND AN ASSOCIATION BETWEEN TUMOR SIZE AND MACROPHAGE INFILTRATE Open
Vestibular schwannomas (VS) comprise 8% of primary brain tumors, with rising prevalence due to increased detection by imaging. How intertumoral heterogeneity and differences within the tumor microenvironment (TME) contribute to the pathoge…
View article: Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
View article: Identification and Management of Aggressive Meningiomas
Identification and Management of Aggressive Meningiomas Open
Meningiomas are common primary central nervous system tumors derived from the meninges, with management most frequently entailing serial monitoring or a combination of surgery and/or radiation therapy. Although often considered benign lesi…
View article: Surgical management of colloid cysts of the third ventricle: a single-institution comparison of endoscopic and microsurgical resection
Surgical management of colloid cysts of the third ventricle: a single-institution comparison of endoscopic and microsurgical resection Open
OBJECTIVE Colloid cysts of the third ventricle are histologically benign lesions that can cause obstructive hydrocephalus and death. Historically, colloid cysts have been removed by open microsurgical approaches. More recently, minimally i…
View article: Additional file 3 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 3 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 3: Cellranger output of single cell RNA-sequencing sample quality metrics.
View article: Additional file 6 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 6 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 6: Target-ligand interactions output from CellChat.
View article: Additional file 2 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 2 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 2: Analysis of principal component genes of different cell types in dura and tumor samples and associated gene ontology biological pathways.
View article: Additional file 7 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 7 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 7: Dura and tumor immune cell DEGs.
View article: Additional file 4 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 4 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 4: DEGs of different Seurat objects
View article: Additional file 5 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response
Additional file 5 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response Open
Additional file 5: Van Hove Markers
View article: Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma Open
View article: CBIO-24. NF2 LOSS-OF-FUNCTION COOPERATES WITH HYPOXIA TO DRIVE RADIATION RESISTANCE IN GRADE 2 MENINGIOMAS
CBIO-24. NF2 LOSS-OF-FUNCTION COOPERATES WITH HYPOXIA TO DRIVE RADIATION RESISTANCE IN GRADE 2 MENINGIOMAS Open
World health organization grade 2 meningiomas (G2M) are associated with an aggressive natural history characterized by frequent recurrence, resistance to radiation therapy (RT), and poor survival. We and others have shown that intratumoral…
View article: Resting-State Functional Magnetic Resonance Imaging Networks as a Quantitative Metric for Impact of Neurosurgical Interventions
Resting-State Functional Magnetic Resonance Imaging Networks as a Quantitative Metric for Impact of Neurosurgical Interventions Open
Objective: Resting-state functional MRI (rs-fMRI) has been used to evaluate brain network connectivity as a result of intracranial surgery but has not been used to compare different neurosurgical procedures. Laser interstitial thermal ther…
View article: Clinical Staging to Estimate the Probability of Severe Postoperative Complications in Patients With Vestibular Schwannoma
Clinical Staging to Estimate the Probability of Severe Postoperative Complications in Patients With Vestibular Schwannoma Open
This cohort study found that, among patients with vestibular schwannoma, symptoms present at initial evaluation, in addition to tumor size, served as predictors of severe postoperative complications. A new clinical severity staging system …
View article: Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response
Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response Open
Recent investigation of the meninges, specifically the dura layer, has highlighted its importance in CNS immune surveillance beyond a purely structural role. However, most of our understanding of the meninges stems from the use of pre-clin…