Biao Cheng
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View article: Hypothesis: platelet-rich plasma as an adjunct therapy for eczema targeting inflammation, skin barrier repair, and chronic recurrence
Hypothesis: platelet-rich plasma as an adjunct therapy for eczema targeting inflammation, skin barrier repair, and chronic recurrence Open
View article: Integrative Analysis Reveals a Key Role for CDKN1A in Impaired Wound Healing in Diabetic Patients
Integrative Analysis Reveals a Key Role for CDKN1A in Impaired Wound Healing in Diabetic Patients Open
These findings shed light on the molecular mechanisms underlying DFU healing, suggesting that targeting FOS and CDKN1A could offer novel therapeutic strategies for enhancing wound healing in diabetic patients.
View article: Viral and non-viral vectors for gene therapy in the treatment of bone-related disorders: molecular insights and clinical perspectives
Viral and non-viral vectors for gene therapy in the treatment of bone-related disorders: molecular insights and clinical perspectives Open
Gene therapy offers a transformative approach for treating debilitating bone disorders by delivering therapeutic genetic material to target sites. The efficacy and safety of this approach are heavily reliant on the chosen delivery vehicle,…
View article: Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress
Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress Open
The production of reactive oxygen species (ROS) and oxidative stress are central to the pathophysiology of diabetic wounds. This environment arises from the interplay of hyperglycemia, mitochondrial dysfunction, and chronic inflammation, l…
View article: The evolution of three generations of platelet concentrates products: a leap from classical formulations to the era of extracellular vesicles
The evolution of three generations of platelet concentrates products: a leap from classical formulations to the era of extracellular vesicles Open
Platelet concentrates (PCs) have evolved from classical formulations to exosome-based therapies, reflecting a paradigm shift in regenerative medicine. This review analyzes three generations of PCs products, comparing their technological pr…
View article: Uridine Kinase-like Protein (GhUKL4) Positively Regulates Resistance to Verticillium Wilt in Cotton
Uridine Kinase-like Protein (GhUKL4) Positively Regulates Resistance to Verticillium Wilt in Cotton Open
Background: Verticillium wilt (VW), caused by the fungal pathogen Verticillium dahliae, is a destructive disease that severely compromises cotton yield and fiber quality. Pyrimidine nucleotides, as essential metabolites and nucleic acid co…
View article: Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota‐Derived Indole‐3‐Propionic Acid
Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota‐Derived Indole‐3‐Propionic Acid Open
Background Barrier dysfunction and dysbiosis of the skin microbiota are two of the key factors in the pathogenesis of atopic dermatitis (AD). Phytic acid (PA) is a common constituent of high‐fiber foods, whereas its role in AD remains unel…
View article: The current landscape of fecal microbiota transplantation in treating inflammatory bowel disease
The current landscape of fecal microbiota transplantation in treating inflammatory bowel disease Open
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a chronic, immune-mediated disorder that impacts the intestinal tract. The gut microbiota, a diverse community of microorganisms, plays a…
View article: Concise Synthesis of Carbocycle‐Fused γ‐Carbolinones via Regio‐/Chemoselective Reaction of Indole‐3‐Carboxamides with Cyclic Diazo Compounds
Concise Synthesis of Carbocycle‐Fused γ‐Carbolinones via Regio‐/Chemoselective Reaction of Indole‐3‐Carboxamides with Cyclic Diazo Compounds Open
γ‐Carboline and γ‐carbolinone are privileged structural scaffolds for the development of new pharmaceuticals and functional materials. A concise and effective synthesis of carbocycle‐fused γ‐carbolinone derivatives via the regio‐ and chemo…
View article: Assessing the efficacy and safety of low dose clopidogrel in Chinese ACS patients undergoing PCI: A retrospective study
Assessing the efficacy and safety of low dose clopidogrel in Chinese ACS patients undergoing PCI: A retrospective study Open
Continuation of single antiplatelet treatment (SAPT) is recommended for patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI) after dual antiplatelet treatment (DAPT). However, the optimal long-te…
View article: Exploration of Travel Patterns of Intercity Metro Passengers—A Case Study in Changsha–Zhuzhou–Xiangtan Metropolitan Area, China
Exploration of Travel Patterns of Intercity Metro Passengers—A Case Study in Changsha–Zhuzhou–Xiangtan Metropolitan Area, China Open
(1) Background: Rapid urban growth in China has extended rail systems to neighboring cities to meet intercity travel needs, making it important to understand intercity travel patterns. (2) Methods: Taking the Changsha–Zhuzhou–Xiangtan Inte…
View article: Therapeutic potential of miR-133a-transfected bone marrow mesenchymal stem cell transplantation in improving cardiac function post-myocardial infarction
Therapeutic potential of miR-133a-transfected bone marrow mesenchymal stem cell transplantation in improving cardiac function post-myocardial infarction Open
View article: The cyclization of human salivary Histatin 1 via click chemistry for skin wound healing
The cyclization of human salivary Histatin 1 via click chemistry for skin wound healing Open
View article: Optimization of Enzyme-Assisted Extraction of Rosemary Essential Oil Using Response Surface Methodology and Its Antioxidant Activity by Activating Nrf2 Signaling Pathway
Optimization of Enzyme-Assisted Extraction of Rosemary Essential Oil Using Response Surface Methodology and Its Antioxidant Activity by Activating Nrf2 Signaling Pathway Open
Rosemary essential oil (REO) is widely recognized as a food flavoring and traditional herb and possesses potential antioxidant activity. However, its low yield rate and unclarified antioxidant mechanism warrant further investigation. In th…
View article: Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating
Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating Open
Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial an…
View article: Antioxidant mechanism of Rosmarinus officinalis essential oil ameliorating pulmonary oxidative stress by activating NRF2 signaling pathway
Antioxidant mechanism of Rosmarinus officinalis essential oil ameliorating pulmonary oxidative stress by activating NRF2 signaling pathway Open
Oxidative stress is a major transduction intermediator of air pollution-related pulmonary disorders, thus the antioxidants defensed with pulmonary oxidative stress need to be further pursued. Rosemary ( Rosmarinus officinalis ) is widely r…
View article: Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds Open
Wound infection is a major problem faced during wound healing. Therefore, it is necessary to develop wound dressings with excellent antimicrobial properties. Here, a smart response system of PVA-TPE/HA-AMP/SF/ALG wound dressing was prepare…
View article: Standardization of Platelet Concentrates in Clinical Practice: New Perspectives
Standardization of Platelet Concentrates in Clinical Practice: New Perspectives Open
View article: Clinical efficacy of blood derivatives on wound healing: A systematic review and network meta‐analysis
Clinical efficacy of blood derivatives on wound healing: A systematic review and network meta‐analysis Open
This study aims to evaluate the clinical effects of different blood derivatives on wound healing using network meta‐analysis. PubMed, Embase, OVID, Web of Science, SCOPUS and Cochrane Central were searched to obtain studies about blood der…
View article: Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age
Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age Open
View article: The correlation of bioactive components between human female adult peripheral and umbilical cord blood platelet-rich plasma
The correlation of bioactive components between human female adult peripheral and umbilical cord blood platelet-rich plasma Open
Background: Few studies have reported the components, especially anti-aging related substances of umbilical cord blood-derived platelet-rich plasma( PRP). Objective: The aim of this study was to compare the concentrations of bioactive comp…
View article: Synthesis and pyrolysis of ethyl maltol ester
Synthesis and pyrolysis of ethyl maltol ester Open
Ethyl maltol is one of the most important aromatic components in food and cigarettes because of its caramel flavour. However, the development of ethyl maltol is limited by problems such as heavy smell, low threshold, strong volatility and …
View article: Application of platelet-rich plasma (PRP) in lips rejuvenation
Application of platelet-rich plasma (PRP) in lips rejuvenation Open
View article: [Role and prospect of regenerative medicine in early treatment of combat trauma].
[Role and prospect of regenerative medicine in early treatment of combat trauma]. Open
The regenerative medicine has made great breakthrough in the repair of combat trauma, showing broad prospects, while the method of regenerative medicine applied in the early treatment of combat trauma is not yet clear. The early treatment …
View article: Editorial: Wound repair: establishment and development of a new discipline in China
Editorial: Wound repair: establishment and development of a new discipline in China Open
EDITORIAL article Front. Surg., 16 May 2023Sec. Reconstructive and Plastic Surgery Volume 10 - 2023 | https://doi.org/10.3389/fsurg.2023.1207709
View article: Weakly acidic microenvironment of the wound bed boosting the efficacy of acidic fibroblast growth factor to promote skin regeneration
Weakly acidic microenvironment of the wound bed boosting the efficacy of acidic fibroblast growth factor to promote skin regeneration Open
The pH value within the wound microenvironment influences indirectly and directly all biochemical reactions taking place in the process of skin wound healing. Currently, it is generally believed that a low pH value, such as it is found on …
View article: Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells
Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells Open
As a critical member in wound healing, vascular endothelial cells (ECs) impaired under high levels of reactive oxygen species (ROS) would hamper neovascularization. Mitochondria transfer can reduce intracellular ROS damage under pathologic…
View article: Metric-guided Distillation: Distilling Knowledge from the Metric to Ranker and Retriever for Generative Commonsense Reasoning
Metric-guided Distillation: Distilling Knowledge from the Metric to Ranker and Retriever for Generative Commonsense Reasoning Open
Commonsense generation aims to generate a realistic sentence describing a daily scene under the given concepts, which is very challenging, since it requires models to have relational reasoning and compositional generalization capabilities.…
View article: The Design and Characterization of a Strong Bio-Ink for Meniscus Regeneration
The Design and Characterization of a Strong Bio-Ink for Meniscus Regeneration Open
The meniscus is vital to the mechanical function of the knee, while it is frequently harmed because it bears a heavy load. A strong bio-ink for meniscus regeneration was prepared for the future meniscal tissue engineering. The prepared bio…
View article: The duration of postoperative analgesic use after total knee arthroplasty and nomogram for predicting prolonged analgesic use
The duration of postoperative analgesic use after total knee arthroplasty and nomogram for predicting prolonged analgesic use Open
Background Total knee arthroplasty is currently a reliable treatment for end-stage knee osteoarthritis. However, chronic postsurgical pain (CPSP) is substantially thought to reduce patient satisfaction. NSAID-based oral analgesics were use…