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View article: PCSK6 ablation in blood circulating cells increases atherosclerotic burden, but improves plaque stability by activating Th17-smooth muscle cell modulatory axis
PCSK6 ablation in blood circulating cells increases atherosclerotic burden, but improves plaque stability by activating Th17-smooth muscle cell modulatory axis Open
Global Pcsk6 ablation leads to the activation of both adaptive and innate immune systems. Interestingly, Pcsk6-/- ablation in bone marrow of hyperlipidemic mice revealed its dual role in atherogenesis, activating a Th17-SMC modulatory axis…
View article: Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease Open
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expressio…
View article: IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis
IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis Open
B and T cells are interconnected in the T follicular helper—germinal center B cell (T FH -GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this axis results in exacerbated atherosclerosis. …
View article: Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice Open
Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown. Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients,…
View article: Genomic evaluation of circulating proteins for drug target characterisation and precision medicine
Genomic evaluation of circulating proteins for drug target characterisation and precision medicine Open
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. By mapping and replicating protein quantitative trait loci (pQTL)…
View article: PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling
PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling Open
Rationale: PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (S…
View article: Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice Open
T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression of the …
View article: P574Activation of the regulatory T-cell-indoleamine 2,3 dioxygenase Axis promotes vascular tolerance mechanisms and reduces atherosclerosis
P574Activation of the regulatory T-cell-indoleamine 2,3 dioxygenase Axis promotes vascular tolerance mechanisms and reduces atherosclerosis Open
vivo (Sugen Hypoxia rat model).Importantly, 6-MP improved impaired cardiac function compared to control group.Conclusions: Our data indicate that Nur77 is a novel critical modulator in PAH through increasing BMP signalling while decreasing…